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Phosphotyrosine-dependent association between CD22 and protein tyrosine phosphatase 1C.
Eur J Immunol. 1995 Jun; 25(6):1573-9.EJ

Abstract

CD22 is a B lymphocyte-specific cell surface glycoprotein that becomes tyrosine phosphorylated upon B cell activation. To determine if tyrosine phosphorylated CD22 couples signaling through membrane immunoglobulin (mIg) to down-stream elements, we looked for molecules coprecipitating with CD22 after anti-Ig stimulation. We found that a 60-kDa molecule was stably associated with CD22 following cross-linking of mIg and have identified this molecule as protein tyrosine phosphatase 1C (PTP1C). The association between PTP1C and CD22 is dependent upon tyrosine phosphorylation of CD22, but does not appear to require tyrosine phosphorylation of PTP1C.

Authors+Show Affiliations

Department of Immunology, Scripps Research Institute, La Jolla, CA 92037, USA.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

7542197

Citation

Campbell, M A., and N R. Klinman. "Phosphotyrosine-dependent Association Between CD22 and Protein Tyrosine Phosphatase 1C." European Journal of Immunology, vol. 25, no. 6, 1995, pp. 1573-9.
Campbell MA, Klinman NR. Phosphotyrosine-dependent association between CD22 and protein tyrosine phosphatase 1C. Eur J Immunol. 1995;25(6):1573-9.
Campbell, M. A., & Klinman, N. R. (1995). Phosphotyrosine-dependent association between CD22 and protein tyrosine phosphatase 1C. European Journal of Immunology, 25(6), 1573-9.
Campbell MA, Klinman NR. Phosphotyrosine-dependent Association Between CD22 and Protein Tyrosine Phosphatase 1C. Eur J Immunol. 1995;25(6):1573-9. PubMed PMID: 7542197.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Phosphotyrosine-dependent association between CD22 and protein tyrosine phosphatase 1C. AU - Campbell,M A, AU - Klinman,N R, PY - 1995/6/1/pubmed PY - 1995/6/1/medline PY - 1995/6/1/entrez SP - 1573 EP - 9 JF - European journal of immunology JO - Eur J Immunol VL - 25 IS - 6 N2 - CD22 is a B lymphocyte-specific cell surface glycoprotein that becomes tyrosine phosphorylated upon B cell activation. To determine if tyrosine phosphorylated CD22 couples signaling through membrane immunoglobulin (mIg) to down-stream elements, we looked for molecules coprecipitating with CD22 after anti-Ig stimulation. We found that a 60-kDa molecule was stably associated with CD22 following cross-linking of mIg and have identified this molecule as protein tyrosine phosphatase 1C (PTP1C). The association between PTP1C and CD22 is dependent upon tyrosine phosphorylation of CD22, but does not appear to require tyrosine phosphorylation of PTP1C. SN - 0014-2980 UR - https://www.unboundmedicine.com/medline/citation/7542197/Phosphotyrosine_dependent_association_between_CD22_and_protein_tyrosine_phosphatase_1C_ L2 - https://doi.org/10.1002/eji.1830250616 DB - PRIME DP - Unbound Medicine ER -