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Gliadin-specific T cell responses in peripheral blood of healthy individuals involve T cells restricted by the coeliac disease associated DQ2 heterodimer.
Scand J Immunol. 1995 Jul; 42(1):166-70.SJ

Abstract

Coeliac disease (CD) is probably caused by an abnormal immune response towards wheat gliadin in the small intestine. We found that gliadin-specific T cells from the small intestinal mucosa of HLA-DQ2 positive CD patients were almost exclusively restricted by the disease-associated DQ2 molecule. In the peripheral blood of CD patients, a large proportion of gliadin-specific T cells were found to be restricted by DQ molecules, including DQ2, but many were instead restricted by DR or DP molecules of the patient. We have now investigated gliadin-specific T cell responses in peripheral blood from healthy individuals. Four of 20 persons tested had strong in vitro responses and were used as donors for gliadin-specific T cell clones. We found gliadin-specific T cells restricted by the CD-associated DQ2 molecule in peripheral blood for two of these four individuals. It is the presence of such T cells also in the small intestinal mucosa which seems typical of CD.

Authors+Show Affiliations

Institute of Transplantation Immunology, University of Oslo, Norway.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

7543212

Citation

Jensen, K, et al. "Gliadin-specific T Cell Responses in Peripheral Blood of Healthy Individuals Involve T Cells Restricted By the Coeliac Disease Associated DQ2 Heterodimer." Scandinavian Journal of Immunology, vol. 42, no. 1, 1995, pp. 166-70.
Jensen K, Sollid LM, Scott H, et al. Gliadin-specific T cell responses in peripheral blood of healthy individuals involve T cells restricted by the coeliac disease associated DQ2 heterodimer. Scand J Immunol. 1995;42(1):166-70.
Jensen, K., Sollid, L. M., Scott, H., Paulsen, G., Kett, K., Thorsby, E., & Lundin, K. E. (1995). Gliadin-specific T cell responses in peripheral blood of healthy individuals involve T cells restricted by the coeliac disease associated DQ2 heterodimer. Scandinavian Journal of Immunology, 42(1), 166-70.
Jensen K, et al. Gliadin-specific T Cell Responses in Peripheral Blood of Healthy Individuals Involve T Cells Restricted By the Coeliac Disease Associated DQ2 Heterodimer. Scand J Immunol. 1995;42(1):166-70. PubMed PMID: 7543212.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Gliadin-specific T cell responses in peripheral blood of healthy individuals involve T cells restricted by the coeliac disease associated DQ2 heterodimer. AU - Jensen,K, AU - Sollid,L M, AU - Scott,H, AU - Paulsen,G, AU - Kett,K, AU - Thorsby,E, AU - Lundin,K E, PY - 1995/7/1/pubmed PY - 1995/7/1/medline PY - 1995/7/1/entrez SP - 166 EP - 70 JF - Scandinavian journal of immunology JO - Scand J Immunol VL - 42 IS - 1 N2 - Coeliac disease (CD) is probably caused by an abnormal immune response towards wheat gliadin in the small intestine. We found that gliadin-specific T cells from the small intestinal mucosa of HLA-DQ2 positive CD patients were almost exclusively restricted by the disease-associated DQ2 molecule. In the peripheral blood of CD patients, a large proportion of gliadin-specific T cells were found to be restricted by DQ molecules, including DQ2, but many were instead restricted by DR or DP molecules of the patient. We have now investigated gliadin-specific T cell responses in peripheral blood from healthy individuals. Four of 20 persons tested had strong in vitro responses and were used as donors for gliadin-specific T cell clones. We found gliadin-specific T cells restricted by the CD-associated DQ2 molecule in peripheral blood for two of these four individuals. It is the presence of such T cells also in the small intestinal mucosa which seems typical of CD. SN - 0300-9475 UR - https://www.unboundmedicine.com/medline/citation/7543212/Gliadin_specific_T_cell_responses_in_peripheral_blood_of_healthy_individuals_involve_T_cells_restricted_by_the_coeliac_disease_associated_DQ2_heterodimer_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0300-9475&date=1995&volume=42&issue=1&spage=166 DB - PRIME DP - Unbound Medicine ER -