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Inhibitory effect of terfenadine, a selective H1 histamine antagonist, on alcoholic beverage-induced bronchoconstriction in asthmatic patients.
Eur Respir J 1995; 8(4):619-23ER

Abstract

We wanted to evaluate the effect of terfenadine, a selective H1-receptor antagonist, on alcoholic beverage-induced bronchoconstriction. Eight patients with alcohol-induced asthma received terfenadine (60 mg, twice on the test day) or placebo, with the last dosing 2 h before the test in a double-blind, randomized, cross-over manner. On two separate study days, each subject drank the same brand and volume of alcoholic beverage (beer or Japanese saké), and bronchoconstriction was assessed as change in peak expiratory flow (PEF) over 120 min postchallenge. Inhalation challenges were performed with the same alcoholic beverage with which they had been orally challenged. The mean (SEM) percentage fall in PEF 15, 30, 45, 60, 90 and 120 min after the oral alcohol challenge was significantly reduced from 12.0 (3.1), 17.0 (1.7), 15.8 (2.3), 15.2 (3.4), 16.6 (4.8) and 14.7 (5.2)%, to 2.6 (1.8), 2.1 (1.6), 3.9 (1.2), 5.7 (2.2), 6.5 (2.6), 5.1 (1.6)%, respectively, by terfenadine. No significant bronchoconstriction was observed after the inhalation challenge. We conclude that the release of histamine makes a major contribution to alcoholic beverage-induced bronchoconstriction in Japanese asthmatic patients, and that histamine H1 antagonists may be effective in preventing alcoholic beverage-induced bronchoconstriction.

Authors+Show Affiliations

Division of Respiratory Medicine, Ishikawa Prefectural Central Hospital, Kanazawa, Japan.

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

7545133

Citation

Myou, S, et al. "Inhibitory Effect of Terfenadine, a Selective H1 Histamine Antagonist, On Alcoholic Beverage-induced Bronchoconstriction in Asthmatic Patients." The European Respiratory Journal, vol. 8, no. 4, 1995, pp. 619-23.
Myou S, Fujimura M, Nishi K, et al. Inhibitory effect of terfenadine, a selective H1 histamine antagonist, on alcoholic beverage-induced bronchoconstriction in asthmatic patients. Eur Respir J. 1995;8(4):619-23.
Myou, S., Fujimura, M., Nishi, K., Ohka, T., & Matsuda, T. (1995). Inhibitory effect of terfenadine, a selective H1 histamine antagonist, on alcoholic beverage-induced bronchoconstriction in asthmatic patients. The European Respiratory Journal, 8(4), pp. 619-23.
Myou S, et al. Inhibitory Effect of Terfenadine, a Selective H1 Histamine Antagonist, On Alcoholic Beverage-induced Bronchoconstriction in Asthmatic Patients. Eur Respir J. 1995;8(4):619-23. PubMed PMID: 7545133.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Inhibitory effect of terfenadine, a selective H1 histamine antagonist, on alcoholic beverage-induced bronchoconstriction in asthmatic patients. AU - Myou,S, AU - Fujimura,M, AU - Nishi,K, AU - Ohka,T, AU - Matsuda,T, PY - 1995/4/1/pubmed PY - 1995/4/1/medline PY - 1995/4/1/entrez SP - 619 EP - 23 JF - The European respiratory journal JO - Eur. Respir. J. VL - 8 IS - 4 N2 - We wanted to evaluate the effect of terfenadine, a selective H1-receptor antagonist, on alcoholic beverage-induced bronchoconstriction. Eight patients with alcohol-induced asthma received terfenadine (60 mg, twice on the test day) or placebo, with the last dosing 2 h before the test in a double-blind, randomized, cross-over manner. On two separate study days, each subject drank the same brand and volume of alcoholic beverage (beer or Japanese saké), and bronchoconstriction was assessed as change in peak expiratory flow (PEF) over 120 min postchallenge. Inhalation challenges were performed with the same alcoholic beverage with which they had been orally challenged. The mean (SEM) percentage fall in PEF 15, 30, 45, 60, 90 and 120 min after the oral alcohol challenge was significantly reduced from 12.0 (3.1), 17.0 (1.7), 15.8 (2.3), 15.2 (3.4), 16.6 (4.8) and 14.7 (5.2)%, to 2.6 (1.8), 2.1 (1.6), 3.9 (1.2), 5.7 (2.2), 6.5 (2.6), 5.1 (1.6)%, respectively, by terfenadine. No significant bronchoconstriction was observed after the inhalation challenge. We conclude that the release of histamine makes a major contribution to alcoholic beverage-induced bronchoconstriction in Japanese asthmatic patients, and that histamine H1 antagonists may be effective in preventing alcoholic beverage-induced bronchoconstriction. SN - 0903-1936 UR - https://www.unboundmedicine.com/medline/citation/7545133/Inhibitory_effect_of_terfenadine_a_selective_H1_histamine_antagonist_on_alcoholic_beverage_induced_bronchoconstriction_in_asthmatic_patients_ L2 - http://erj.ersjournals.com/cgi/pmidlookup?view=long&pmid=7545133 DB - PRIME DP - Unbound Medicine ER -