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Detection of autoantibodies against oxidized low-density lipoproteins and of IgG-bound low density lipoproteins in patients with coronary artery disease.
Clin Chim Acta. 1995 Jun 30; 238(1):1-10.CC

Abstract

The role of oxidized low-density lipoprotein (ox-LDL) in the pathogenesis of atherosclerosis has been the object of intense investigation. It has been proposed that, due to the antigenic properties of ox-LDL, the anti-ox-LDL antibody titre could represent a useful index of in vivo LDL oxidation. On the other hand, LDL immune complexes (LDL-IC) have been demonstrated in patients with coronary disease and could play an atherogenic role. The goal of our study was to investigate anti-malondialdehyde (MDA)-LDL autoantibodies and LDL-IC in a cohort of patients with coronary artery disease. Seventy control subjects and 70 coronary angiographically documented patients were compared; in addition 32 healthy male non-smokers were compared with 32 healthy male smokers (> 10 cigarettes/day). All patients were matched for age and cholesterolemia. Enzyme-linked immunosorbent assay was used to measure anti-MDA-LDL autoantibodies and LDL-IC. Titres of anti-MDA-LDL autoantibodies were not larger in patients with documented coronary artery stenosis and in smokers than they were in controls and non-smokers. The titre of LDL-IC was not higher in patients with coronary artery stenosis than in controls. The results thus indicate that in populations matched for age and cholesterolemia the titres of anti-MDA-LDL autoantibodies and the titre of LDL-IC are not increased in patients suffering from coronary artery stenosis. Furthermore, cigarette smoking does not induce higher titres of anti-MDA-LDL autoantibodies in healthy patients.

Authors+Show Affiliations

Département d'études et de recherches sur les lipoprotéines et l'athérosclérose, SERLIA et INSERM U325, Institut Pasteur, Faculté de pharmacie, Lille, France.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article

Language

eng

PubMed ID

7554289

Citation

Boullier, A, et al. "Detection of Autoantibodies Against Oxidized Low-density Lipoproteins and of IgG-bound Low Density Lipoproteins in Patients With Coronary Artery Disease." Clinica Chimica Acta; International Journal of Clinical Chemistry, vol. 238, no. 1, 1995, pp. 1-10.
Boullier A, Hamon M, Walters-Laporte E, et al. Detection of autoantibodies against oxidized low-density lipoproteins and of IgG-bound low density lipoproteins in patients with coronary artery disease. Clin Chim Acta. 1995;238(1):1-10.
Boullier, A., Hamon, M., Walters-Laporte, E., Martin-Nizart, F., Mackereel, R., Fruchart, J. C., Bertrand, M., & Duriez, P. (1995). Detection of autoantibodies against oxidized low-density lipoproteins and of IgG-bound low density lipoproteins in patients with coronary artery disease. Clinica Chimica Acta; International Journal of Clinical Chemistry, 238(1), 1-10.
Boullier A, et al. Detection of Autoantibodies Against Oxidized Low-density Lipoproteins and of IgG-bound Low Density Lipoproteins in Patients With Coronary Artery Disease. Clin Chim Acta. 1995 Jun 30;238(1):1-10. PubMed PMID: 7554289.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Detection of autoantibodies against oxidized low-density lipoproteins and of IgG-bound low density lipoproteins in patients with coronary artery disease. AU - Boullier,A, AU - Hamon,M, AU - Walters-Laporte,E, AU - Martin-Nizart,F, AU - Mackereel,R, AU - Fruchart,J C, AU - Bertrand,M, AU - Duriez,P, PY - 1995/6/30/pubmed PY - 1995/6/30/medline PY - 1995/6/30/entrez SP - 1 EP - 10 JF - Clinica chimica acta; international journal of clinical chemistry JO - Clin. Chim. Acta VL - 238 IS - 1 N2 - The role of oxidized low-density lipoprotein (ox-LDL) in the pathogenesis of atherosclerosis has been the object of intense investigation. It has been proposed that, due to the antigenic properties of ox-LDL, the anti-ox-LDL antibody titre could represent a useful index of in vivo LDL oxidation. On the other hand, LDL immune complexes (LDL-IC) have been demonstrated in patients with coronary disease and could play an atherogenic role. The goal of our study was to investigate anti-malondialdehyde (MDA)-LDL autoantibodies and LDL-IC in a cohort of patients with coronary artery disease. Seventy control subjects and 70 coronary angiographically documented patients were compared; in addition 32 healthy male non-smokers were compared with 32 healthy male smokers (> 10 cigarettes/day). All patients were matched for age and cholesterolemia. Enzyme-linked immunosorbent assay was used to measure anti-MDA-LDL autoantibodies and LDL-IC. Titres of anti-MDA-LDL autoantibodies were not larger in patients with documented coronary artery stenosis and in smokers than they were in controls and non-smokers. The titre of LDL-IC was not higher in patients with coronary artery stenosis than in controls. The results thus indicate that in populations matched for age and cholesterolemia the titres of anti-MDA-LDL autoantibodies and the titre of LDL-IC are not increased in patients suffering from coronary artery stenosis. Furthermore, cigarette smoking does not induce higher titres of anti-MDA-LDL autoantibodies in healthy patients. SN - 0009-8981 UR - https://www.unboundmedicine.com/medline/citation/7554289/Detection_of_autoantibodies_against_oxidized_low_density_lipoproteins_and_of_IgG_bound_low_density_lipoproteins_in_patients_with_coronary_artery_disease_ L2 - https://linkinghub.elsevier.com/retrieve/pii/000989819506054H DB - PRIME DP - Unbound Medicine ER -