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[Role of the virologic laboratory in the diagnosis of subacute sclerosing panencephalitis. Report of 12 cases studied between May, 1977 and March, 1978].
Boll Ist Sieroter Milan. 1978 Nov 30; 57(5):575-82.BI

Abstract

Measles h.i.a. and c.f.a. were titrated in serum and cerebrospinal fluid of 12 SSPE patients. Specific IgM h.i.a. in the same specimens were also determined. Pretreatment of the sera by monkey red blood cell absorption, by kaolin or by heparin MnCl2, did not significantly affect h.i.a. titres, but h.i.a. were no more demonstrable in cerebrospinal fluids after kaolin and titres were somewhat lowered by heparin-MnCl2 treatment. By both h.i. and c.f. tests measles antibody were found at much higher titres in sera of SSPE patients than in controls of the same age. H.i.a. and, with one exception, c.f.a. were found in each of the 9 available cerebrospinal fluids from patients, but in none of the 6 specimens from non-SSPE cases. Ratio GM titers h.i.a. over GM titers c.f.a. in sera of SSPE patients was about 1, a value far from that found under different immunization conditions. In control sera, for instance, the ratio was 5.3. Specific IgM were never found in the cerebrospinal fluids and in only 2 out of the 10 sera examined.

Authors

Ferrante P
No affiliation info available
Profeta ML
No affiliation info available
Fasan M
No affiliation info available

MeSH

AdolescentAntibodies, ViralAntibody SpecificityChildComplement Fixation TestsFemaleHemagglutination Inhibition TestsHumansImmunoglobulin MMaleMeasles virusSubacute Sclerosing Panencephalitis

Pub Type(s)

English Abstract
Journal Article

Language

ita

PubMed ID

755485

Citation

Ferrante, P, et al. "[Role of the Virologic Laboratory in the Diagnosis of Subacute Sclerosing Panencephalitis. Report of 12 Cases Studied Between May, 1977 and March, 1978]." Bollettino dell'Istituto Sieroterapico Milanese, vol. 57, no. 5, 1978, pp. 575-82.
Ferrante P, Profeta ML, Fasan M. [Role of the virologic laboratory in the diagnosis of subacute sclerosing panencephalitis. Report of 12 cases studied between May, 1977 and March, 1978]. Boll Ist Sieroter Milan. 1978;57(5):575-82.
Ferrante, P., Profeta, M. L., & Fasan, M. (1978). [Role of the virologic laboratory in the diagnosis of subacute sclerosing panencephalitis. Report of 12 cases studied between May, 1977 and March, 1978]. Bollettino dell'Istituto Sieroterapico Milanese, 57(5), 575-82.
Ferrante P, Profeta ML, Fasan M. [Role of the Virologic Laboratory in the Diagnosis of Subacute Sclerosing Panencephalitis. Report of 12 Cases Studied Between May, 1977 and March, 1978]. Boll Ist Sieroter Milan. 1978 Nov 30;57(5):575-82. PubMed PMID: 755485.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Role of the virologic laboratory in the diagnosis of subacute sclerosing panencephalitis. Report of 12 cases studied between May, 1977 and March, 1978]. AU - Ferrante,P, AU - Profeta,M L, AU - Fasan,M, PY - 1978/11/30/pubmed PY - 1978/11/30/medline PY - 1978/11/30/entrez SP - 575 EP - 82 JF - Bollettino dell'Istituto sieroterapico milanese JO - Boll Ist Sieroter Milan VL - 57 IS - 5 N2 - Measles h.i.a. and c.f.a. were titrated in serum and cerebrospinal fluid of 12 SSPE patients. Specific IgM h.i.a. in the same specimens were also determined. Pretreatment of the sera by monkey red blood cell absorption, by kaolin or by heparin MnCl2, did not significantly affect h.i.a. titres, but h.i.a. were no more demonstrable in cerebrospinal fluids after kaolin and titres were somewhat lowered by heparin-MnCl2 treatment. By both h.i. and c.f. tests measles antibody were found at much higher titres in sera of SSPE patients than in controls of the same age. H.i.a. and, with one exception, c.f.a. were found in each of the 9 available cerebrospinal fluids from patients, but in none of the 6 specimens from non-SSPE cases. Ratio GM titers h.i.a. over GM titers c.f.a. in sera of SSPE patients was about 1, a value far from that found under different immunization conditions. In control sera, for instance, the ratio was 5.3. Specific IgM were never found in the cerebrospinal fluids and in only 2 out of the 10 sera examined. SN - 0021-2547 UR - https://www.unboundmedicine.com/medline/citation/755485/[Role_of_the_virologic_laboratory_in_the_diagnosis_of_subacute_sclerosing_panencephalitis__Report_of_12_cases_studied_between_May_1977_and_March_1978]_ L2 - https://www.diseaseinfosearch.org/result/6907 DB - PRIME DP - Unbound Medicine ER -