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Ovarian function during low-dose oral contraceptive use.
Contraception. 1995 Jun; 51(6):329-33.C

Abstract

Lowering the total steroid dose in modern oral contraceptives (OCs) has been connected with a higher incidence of ovarian follicle and cyst formation. To investigate the presence of ovarian follicles and cysts by means of vaginal ultrasonography and serum hormone determinations during use of two low-dose OCs, 65 volunteers were randomized to receive either 20 micrograms ethinylestradiol (EE) + 150 micrograms desogestrel (group A) or 35 micrograms EE + 250 micrograms norgestimate (group B) for a 2-month study period. At baseline, 39% of women in group A and 31% in group B exhibited at least one follicle < 35 mm in diameter. By the end of the second treatment cycle, the frequency of these follicles had decreased to 14% in each group. Only one subject in the higher estrogen group developed an ovarian cyst > 35 mm. One subject in each group demonstrated hormone levels characteristic of ovulation; no pregnancy occurred in either group. The 20 micrograms EE preparation was not found to lead more often to ovarian follicles or cysts when compared with a 35 micrograms EE preparation, possibly because of the type and dose of the progestogen used.

Authors+Show Affiliations

Department of Obstetrics and Gynecology, University of Vienna, Austria.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

7554971

Citation

Egarter, C, et al. "Ovarian Function During Low-dose Oral Contraceptive Use." Contraception, vol. 51, no. 6, 1995, pp. 329-33.
Egarter C, Putz M, Strohmer H, et al. Ovarian function during low-dose oral contraceptive use. Contraception. 1995;51(6):329-33.
Egarter, C., Putz, M., Strohmer, H., Speiser, P., Wenzl, R., & Huber, J. (1995). Ovarian function during low-dose oral contraceptive use. Contraception, 51(6), 329-33.
Egarter C, et al. Ovarian Function During Low-dose Oral Contraceptive Use. Contraception. 1995;51(6):329-33. PubMed PMID: 7554971.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ovarian function during low-dose oral contraceptive use. AU - Egarter,C, AU - Putz,M, AU - Strohmer,H, AU - Speiser,P, AU - Wenzl,R, AU - Huber,J, PY - 1995/6/1/pubmed PY - 1995/6/1/medline PY - 1995/6/1/entrez KW - Austria KW - Biology KW - Comparative Studies KW - Contraception KW - Contraceptive Agents KW - Contraceptive Agents, Female KW - Contraceptive Agents, Progestin KW - Contraceptive Methods KW - Desogestrel KW - Developed Countries KW - Diseases KW - Europe KW - Family Planning KW - Genitalia KW - Genitalia, Female KW - Norgestimate KW - Oral Contraceptives KW - Oral Contraceptives, Low-dose KW - Ovarian Cysts KW - Ovarian Effects KW - Ovary KW - Physiology KW - Research Methodology KW - Research Report KW - Studies KW - Urogenital System KW - Western Europe SP - 329 EP - 33 JF - Contraception JO - Contraception VL - 51 IS - 6 N2 - Lowering the total steroid dose in modern oral contraceptives (OCs) has been connected with a higher incidence of ovarian follicle and cyst formation. To investigate the presence of ovarian follicles and cysts by means of vaginal ultrasonography and serum hormone determinations during use of two low-dose OCs, 65 volunteers were randomized to receive either 20 micrograms ethinylestradiol (EE) + 150 micrograms desogestrel (group A) or 35 micrograms EE + 250 micrograms norgestimate (group B) for a 2-month study period. At baseline, 39% of women in group A and 31% in group B exhibited at least one follicle < 35 mm in diameter. By the end of the second treatment cycle, the frequency of these follicles had decreased to 14% in each group. Only one subject in the higher estrogen group developed an ovarian cyst > 35 mm. One subject in each group demonstrated hormone levels characteristic of ovulation; no pregnancy occurred in either group. The 20 micrograms EE preparation was not found to lead more often to ovarian follicles or cysts when compared with a 35 micrograms EE preparation, possibly because of the type and dose of the progestogen used. SN - 0010-7824 UR - https://www.unboundmedicine.com/medline/citation/7554971/Ovarian_function_during_low_dose_oral_contraceptive_use_ L2 - https://linkinghub.elsevier.com/retrieve/pii/001078249500096S DB - PRIME DP - Unbound Medicine ER -