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Effect of two oral contraceptives containing ethinylestradiol and gestodene or norgestimate upon androgen parameters and serum binding proteins.
Contraception. 1995 Jun; 51(6):341-6.C

Abstract

The effect of a triphasic oral contraceptive containing ethinylestradiol and gestodene (EE/GSD) on various serum hormonal parameters was compared with that of a monophasic formulation containing 35 micrograms ethinylestradiol and 250 micrograms norgestimate (EE/NGM). Blood samples were collected from 46 women on days 2, 11, and 21 of the preceding control cycle and of the third, sixth and twelfth treatment cycle. There was no significant difference in the influence on any hormonal parameter between both formulations. Both EE/GSD and EE/NGM caused a time-dependent suppression of serum dehydroepiandrosterone sulphate (DHEA-S) by 20-30% (p < 0.01) and a reduction of 5 alpha-androstane-3 alpha, 17 beta-diol glucuronide by 50-60% (p < 0.01) during each treatment cycle, while androstenedione levels were reduced by 25% (p < 0.01). There was also a significant decrease in the levels of total testosterone by 30-35% (p < 0.01) and free testosterone by 60% (p < 0.01), while sex hormone-binding globulin (SHBG) was increased by 200-240% on days 11 and 21 (p < 0.01). During the pill-free interval the SHBG levels were reduced to a certain degree but remained elevated by 100% as compared to the pretreatment values. The serum levels of corticosteroid-binding globulin (CBG) which is known to be influenced only by the estrogenic component of combination pills, increased significantly by 170% (p < 0.01) during each treatment cycle. During the pill-free interval of 7 days, the CBG levels decreased but were still elevated by 90-100% as compared to the control cycle. Similarly, the serum levels of cortisol were significantly elevated by 110-140% (p < 0.01) during treatment with both preparations. The results demonstrate a profound suppression of androgen levels and peripheral androgen metabolism.

Authors+Show Affiliations

Department of Obstetrics and Gynecology, J.W. Goethe University Frankfurt, Germany.No affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

7554973

Citation

Wiegratz, I, et al. "Effect of Two Oral Contraceptives Containing Ethinylestradiol and Gestodene or Norgestimate Upon Androgen Parameters and Serum Binding Proteins." Contraception, vol. 51, no. 6, 1995, pp. 341-6.
Wiegratz I, Jung-Hoffmann C, Kuhl H. Effect of two oral contraceptives containing ethinylestradiol and gestodene or norgestimate upon androgen parameters and serum binding proteins. Contraception. 1995;51(6):341-6.
Wiegratz, I., Jung-Hoffmann, C., & Kuhl, H. (1995). Effect of two oral contraceptives containing ethinylestradiol and gestodene or norgestimate upon androgen parameters and serum binding proteins. Contraception, 51(6), 341-6.
Wiegratz I, Jung-Hoffmann C, Kuhl H. Effect of Two Oral Contraceptives Containing Ethinylestradiol and Gestodene or Norgestimate Upon Androgen Parameters and Serum Binding Proteins. Contraception. 1995;51(6):341-6. PubMed PMID: 7554973.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of two oral contraceptives containing ethinylestradiol and gestodene or norgestimate upon androgen parameters and serum binding proteins. AU - Wiegratz,I, AU - Jung-Hoffmann,C, AU - Kuhl,H, PY - 1995/6/1/pubmed PY - 1995/6/1/medline PY - 1995/6/1/entrez KW - Adrenal Cortex Hormones KW - Androgens KW - Biology KW - Clinical Research KW - Comparative Studies KW - Contraception KW - Contraceptive Agents KW - Contraceptive Agents, Female KW - Contraceptive Agents, Progestin KW - Contraceptive Methods KW - Developed Countries KW - Endocrine System KW - Europe KW - Family Planning KW - Germany KW - Gestodene KW - Hormones KW - Metabolic Effects KW - Norgestimate KW - Oral Contraceptives KW - Oral Contraceptives, Combined KW - Oral Contraceptives, Phasic KW - Physiology KW - Research Methodology KW - Research Report KW - Steroid Metabolic Effects KW - Studies KW - Western Europe SP - 341 EP - 6 JF - Contraception JO - Contraception VL - 51 IS - 6 N2 - The effect of a triphasic oral contraceptive containing ethinylestradiol and gestodene (EE/GSD) on various serum hormonal parameters was compared with that of a monophasic formulation containing 35 micrograms ethinylestradiol and 250 micrograms norgestimate (EE/NGM). Blood samples were collected from 46 women on days 2, 11, and 21 of the preceding control cycle and of the third, sixth and twelfth treatment cycle. There was no significant difference in the influence on any hormonal parameter between both formulations. Both EE/GSD and EE/NGM caused a time-dependent suppression of serum dehydroepiandrosterone sulphate (DHEA-S) by 20-30% (p < 0.01) and a reduction of 5 alpha-androstane-3 alpha, 17 beta-diol glucuronide by 50-60% (p < 0.01) during each treatment cycle, while androstenedione levels were reduced by 25% (p < 0.01). There was also a significant decrease in the levels of total testosterone by 30-35% (p < 0.01) and free testosterone by 60% (p < 0.01), while sex hormone-binding globulin (SHBG) was increased by 200-240% on days 11 and 21 (p < 0.01). During the pill-free interval the SHBG levels were reduced to a certain degree but remained elevated by 100% as compared to the pretreatment values. The serum levels of corticosteroid-binding globulin (CBG) which is known to be influenced only by the estrogenic component of combination pills, increased significantly by 170% (p < 0.01) during each treatment cycle. During the pill-free interval of 7 days, the CBG levels decreased but were still elevated by 90-100% as compared to the control cycle. Similarly, the serum levels of cortisol were significantly elevated by 110-140% (p < 0.01) during treatment with both preparations. The results demonstrate a profound suppression of androgen levels and peripheral androgen metabolism. SN - 0010-7824 UR - https://www.unboundmedicine.com/medline/citation/7554973/Effect_of_two_oral_contraceptives_containing_ethinylestradiol_and_gestodene_or_norgestimate_upon_androgen_parameters_and_serum_binding_proteins_ L2 - https://linkinghub.elsevier.com/retrieve/pii/001078249500098U DB - PRIME DP - Unbound Medicine ER -