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Effect of levonorgestrel-releasing intrauterine device on hormonal profile and menstrual pattern after long-term use.
Contraception. 1995 Jun; 51(6):359-65.C

Abstract

In the present study 14 women after 6 years' use of levonorgestrel-releasing IUD were investigated for the changes of LH, progesterone (P), estradiol (E2), prolactin (PRL) and serum binding globulin (SHBG) in relation to the levonorgestrel levels throughout a segment of 26-40 days with the aim of comparing the hormonal profiles with those during the first year of use of Lng-IUD. Ultrasound scanning was used to follow the development of follicles along with the RIA measurement of hormones. The results of serum LH, P and E2 showed ovulation in 11 cases with either normal menstrual cycles (5 cases), prolonged or irregular cycles (4 cases) or with amenorrhea for 2-3 years (2 cases). One case showed insufficiency of luteal function and 2 cases showed anovulation but with follicular hyperactivity. Higher percentages of ovulatory cycles (78.5%) were found after 6 years of use. No case of complete suppression of ovulation was found. Anovulatory cycles only constituted 14.3%. Clinically, the development of follicles followed by ultrasound scanning further confirmed the hormonal findings. The persistent enlargement of follicles coincided with high levels of E2. After 6 years of use, the serum levels of levonorgestrel were still maintained at mean levels of 314.26 pmol/L and 470.63 pmol/L in the ovulatory and anovulatory groups, respectively. It is concluded that over two-thirds of the cases have ovulatory cycles after long-term use of Lng-IUD; the contraceptive effect is mainly due to its local action on the endometrium, with much less effect on the ovarian function.

Authors+Show Affiliations

National Research Institute for Family Planning, WHO Collaborating Centre for Research in Human Reproduction, Haidian District, Beijing, People's Republic of China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

7554977

Citation

Xiao, B, et al. "Effect of Levonorgestrel-releasing Intrauterine Device On Hormonal Profile and Menstrual Pattern After Long-term Use." Contraception, vol. 51, no. 6, 1995, pp. 359-65.
Xiao B, Zeng T, Wu S, et al. Effect of levonorgestrel-releasing intrauterine device on hormonal profile and menstrual pattern after long-term use. Contraception. 1995;51(6):359-65.
Xiao, B., Zeng, T., Wu, S., Sun, H., & Xiao, N. (1995). Effect of levonorgestrel-releasing intrauterine device on hormonal profile and menstrual pattern after long-term use. Contraception, 51(6), 359-65.
Xiao B, et al. Effect of Levonorgestrel-releasing Intrauterine Device On Hormonal Profile and Menstrual Pattern After Long-term Use. Contraception. 1995;51(6):359-65. PubMed PMID: 7554977.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of levonorgestrel-releasing intrauterine device on hormonal profile and menstrual pattern after long-term use. AU - Xiao,B, AU - Zeng,T, AU - Wu,S, AU - Sun,H, AU - Xiao,N, PY - 1995/6/1/pubmed PY - 1995/6/1/medline PY - 1995/6/1/entrez KW - Anovulation KW - Asia KW - Biology KW - China KW - Clinical Research KW - Contraception KW - Contraceptive Agents KW - Contraceptive Agents, Female KW - Contraceptive Agents, Progestin KW - Contraceptive Methods KW - Demographic Factors KW - Developing Countries KW - Eastern Asia KW - Endocrine System KW - Endometrial Effects KW - Endometrium KW - Estradiol KW - Estrogens KW - Family Planning KW - Genitalia KW - Genitalia, Female KW - Gonadotropins KW - Gonadotropins, Pituitary KW - Hormones KW - Iud KW - Iud, Hormone Releasing KW - Levonorgestrel KW - Luteinizing Hormone KW - Ovarian Effects KW - Ovary KW - Physiology KW - Population KW - Population Dynamics KW - Progestational Hormones KW - Progesterone KW - Research Methodology KW - Research Report KW - Time Factors KW - Urogenital System KW - Uterus SP - 359 EP - 65 JF - Contraception JO - Contraception VL - 51 IS - 6 N2 - In the present study 14 women after 6 years' use of levonorgestrel-releasing IUD were investigated for the changes of LH, progesterone (P), estradiol (E2), prolactin (PRL) and serum binding globulin (SHBG) in relation to the levonorgestrel levels throughout a segment of 26-40 days with the aim of comparing the hormonal profiles with those during the first year of use of Lng-IUD. Ultrasound scanning was used to follow the development of follicles along with the RIA measurement of hormones. The results of serum LH, P and E2 showed ovulation in 11 cases with either normal menstrual cycles (5 cases), prolonged or irregular cycles (4 cases) or with amenorrhea for 2-3 years (2 cases). One case showed insufficiency of luteal function and 2 cases showed anovulation but with follicular hyperactivity. Higher percentages of ovulatory cycles (78.5%) were found after 6 years of use. No case of complete suppression of ovulation was found. Anovulatory cycles only constituted 14.3%. Clinically, the development of follicles followed by ultrasound scanning further confirmed the hormonal findings. The persistent enlargement of follicles coincided with high levels of E2. After 6 years of use, the serum levels of levonorgestrel were still maintained at mean levels of 314.26 pmol/L and 470.63 pmol/L in the ovulatory and anovulatory groups, respectively. It is concluded that over two-thirds of the cases have ovulatory cycles after long-term use of Lng-IUD; the contraceptive effect is mainly due to its local action on the endometrium, with much less effect on the ovarian function. SN - 0010-7824 UR - https://www.unboundmedicine.com/medline/citation/7554977/Effect_of_levonorgestrel_releasing_intrauterine_device_on_hormonal_profile_and_menstrual_pattern_after_long_term_use_ L2 - https://linkinghub.elsevier.com/retrieve/pii/001078249500102G DB - PRIME DP - Unbound Medicine ER -