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Effects of a histamine H2 receptor agonist and antagonist on restraint-induced antinociception in female mice.
Eur J Pharmacol. 1995 Jun 12; 279(2-3):109-13.EJ

Abstract

Restraint for 1 h induced significant antinociceptive activity, as assessed by the hot plate test, in female mice. The antinociceptive activity was significant throughout the 1 h period of observation starting immediately after restraint. Prior administration of the histamine H2 receptor agonist dimaprit (1.5-6.0 mg/kg s.c.) 15 min before restraint further enhanced the restraint-induced antinociceptive activity. Furthermore, the induction of antinociceptive activity by restraint was antagonised by prior administration of histamine H2 receptor antagonists, cimetidine (2.5-10.0 mg/kg s.c.) or zolantidine (2.5-10.0 mg/kg s.c.). However, when these drugs were administered immediately after restraint for 1 h, the antinociceptive activity observed was similar to those restrained animals receiving saline injection. The histamine receptor agonist and antagonists, at the doses used in the present study, did not affect the response of unrestrained animals to the hot plate test. These results demonstrate that the effect of a histamine H2 receptor agonist and antagonists on restraint-induced antinociception is dependent upon their time of administration and may act by altering the intensity of stress, thus affecting the antinociceptive activity induced.

Authors+Show Affiliations

School of Pharmacy and Biomedical Sciences, University of Portsmouth, Hampshire, UK.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

7556390

Citation

Wong, C L.. "Effects of a Histamine H2 Receptor Agonist and Antagonist On Restraint-induced Antinociception in Female Mice." European Journal of Pharmacology, vol. 279, no. 2-3, 1995, pp. 109-13.
Wong CL. Effects of a histamine H2 receptor agonist and antagonist on restraint-induced antinociception in female mice. Eur J Pharmacol. 1995;279(2-3):109-13.
Wong, C. L. (1995). Effects of a histamine H2 receptor agonist and antagonist on restraint-induced antinociception in female mice. European Journal of Pharmacology, 279(2-3), 109-13.
Wong CL. Effects of a Histamine H2 Receptor Agonist and Antagonist On Restraint-induced Antinociception in Female Mice. Eur J Pharmacol. 1995 Jun 12;279(2-3):109-13. PubMed PMID: 7556390.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of a histamine H2 receptor agonist and antagonist on restraint-induced antinociception in female mice. A1 - Wong,C L, PY - 1995/6/12/pubmed PY - 1995/6/12/medline PY - 1995/6/12/entrez SP - 109 EP - 13 JF - European journal of pharmacology JO - Eur J Pharmacol VL - 279 IS - 2-3 N2 - Restraint for 1 h induced significant antinociceptive activity, as assessed by the hot plate test, in female mice. The antinociceptive activity was significant throughout the 1 h period of observation starting immediately after restraint. Prior administration of the histamine H2 receptor agonist dimaprit (1.5-6.0 mg/kg s.c.) 15 min before restraint further enhanced the restraint-induced antinociceptive activity. Furthermore, the induction of antinociceptive activity by restraint was antagonised by prior administration of histamine H2 receptor antagonists, cimetidine (2.5-10.0 mg/kg s.c.) or zolantidine (2.5-10.0 mg/kg s.c.). However, when these drugs were administered immediately after restraint for 1 h, the antinociceptive activity observed was similar to those restrained animals receiving saline injection. The histamine receptor agonist and antagonists, at the doses used in the present study, did not affect the response of unrestrained animals to the hot plate test. These results demonstrate that the effect of a histamine H2 receptor agonist and antagonists on restraint-induced antinociception is dependent upon their time of administration and may act by altering the intensity of stress, thus affecting the antinociceptive activity induced. SN - 0014-2999 UR - https://www.unboundmedicine.com/medline/citation/7556390/Effects_of_a_histamine_H2_receptor_agonist_and_antagonist_on_restraint_induced_antinociception_in_female_mice_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0014-2999(95)00129-9 DB - PRIME DP - Unbound Medicine ER -