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Atypical polypoid adenomyomas of the uterus.
Histopathology. 1995 Jul; 27(1):35-42.H

Abstract

We performed a clinicopathological immunohistochemical, ultrastructural, and flow cytometric study on six cases of atypical polypoid adenomyoma of the uterus including one with an adenocarcinoma within it. The tumours occurred in nulliparous women aged 22-48 years (average, 33.0 years); three arose in the uterine corpus, and three in the endocervix. Histologically, they were composed of endometrial glands admixed with a stromal component of interlacing bundles of smooth muscle cells. The glands exhibited varying degrees of architectural and cytological atypia. Most of the stromal cells showed strong staining for HHF35, alpha-smooth muscle actin, and vimentin, and some cells contained desmin. Electronmicroscopy, in one case, confirmed the presence of a well-differentiated smooth muscle component. The stromal component may arise as a result of extensive metaplasia of endometrial stromal cells. Uninvolved endometrium showed ciliated cell metaplasia in three patients, and atypical complex hyperplasia in two. One patient had a well-differentiated adenocarcinoma of endometrioid type arising in an endocervical atypical polypoid adenomyoma. All tumours had a diploid DNA content and relatively small S phase fraction (average, 6.23%). The follow-up periods ranged from 4 to 42 months (average, 13.5 months), and all patients were alive and well. Although the histogenesis of atypical polypoid adenomyoma of the uterus remains uncertain, it is suggested that it may arise because of oestrogen-related factors.

Authors+Show Affiliations

Department of Pathology, Jikei University School of Medicine, Tokyo, Japan.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

7557904

Citation

Fukunaga, M, et al. "Atypical Polypoid Adenomyomas of the Uterus." Histopathology, vol. 27, no. 1, 1995, pp. 35-42.
Fukunaga M, Endo Y, Ushigome S, et al. Atypical polypoid adenomyomas of the uterus. Histopathology. 1995;27(1):35-42.
Fukunaga, M., Endo, Y., Ushigome, S., & Ishikawa, E. (1995). Atypical polypoid adenomyomas of the uterus. Histopathology, 27(1), 35-42.
Fukunaga M, et al. Atypical Polypoid Adenomyomas of the Uterus. Histopathology. 1995;27(1):35-42. PubMed PMID: 7557904.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Atypical polypoid adenomyomas of the uterus. AU - Fukunaga,M, AU - Endo,Y, AU - Ushigome,S, AU - Ishikawa,E, PY - 1995/7/1/pubmed PY - 1995/7/1/medline PY - 1995/7/1/entrez SP - 35 EP - 42 JF - Histopathology JO - Histopathology VL - 27 IS - 1 N2 - We performed a clinicopathological immunohistochemical, ultrastructural, and flow cytometric study on six cases of atypical polypoid adenomyoma of the uterus including one with an adenocarcinoma within it. The tumours occurred in nulliparous women aged 22-48 years (average, 33.0 years); three arose in the uterine corpus, and three in the endocervix. Histologically, they were composed of endometrial glands admixed with a stromal component of interlacing bundles of smooth muscle cells. The glands exhibited varying degrees of architectural and cytological atypia. Most of the stromal cells showed strong staining for HHF35, alpha-smooth muscle actin, and vimentin, and some cells contained desmin. Electronmicroscopy, in one case, confirmed the presence of a well-differentiated smooth muscle component. The stromal component may arise as a result of extensive metaplasia of endometrial stromal cells. Uninvolved endometrium showed ciliated cell metaplasia in three patients, and atypical complex hyperplasia in two. One patient had a well-differentiated adenocarcinoma of endometrioid type arising in an endocervical atypical polypoid adenomyoma. All tumours had a diploid DNA content and relatively small S phase fraction (average, 6.23%). The follow-up periods ranged from 4 to 42 months (average, 13.5 months), and all patients were alive and well. Although the histogenesis of atypical polypoid adenomyoma of the uterus remains uncertain, it is suggested that it may arise because of oestrogen-related factors. SN - 0309-0167 UR - https://www.unboundmedicine.com/medline/citation/7557904/Atypical_polypoid_adenomyomas_of_the_uterus_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0309-0167&date=1995&volume=27&issue=1&spage=35 DB - PRIME DP - Unbound Medicine ER -