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Nasopharyngeal antibodies to pneumococcal capsular polysaccharides in children with acute otitis media.
J Infect Dis. 1995 Oct; 172(4):1115-8.JI

Abstract

Antibodies to pneumococcal capsular polysaccharides were measured by EIA in acute- and convalescent-phase nasopharyngeal aspirates from 120 children with acute otitis media. Nasopharyngeal IgM- and IgG-class antibodies were rare, whereas IgA was detected more often, occurred independently from serum IgA, and correlated with the presence of the secretory component in pneumococcal antibody, indicating local production of IgA. Thirty-four percent of the children with pneumococci in middle ear fluid developed a nasopharyngeal IgA response to the polysaccharide pool of serotypes 6B, 14, 19F, and 23F compared with 7% of the children with pneumococci only in the nasopharynx or not found at all (P = .004). The responses were observed in children of all ages, the youngest 6 months of age. This supports the hypothesis that mucosal immunity to bacterial polysaccharides matures earlier than systemic immunity.

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Authors+Show Affiliations

Virolainen A
Department of Otolaryngology, University of Helsinki, Finland.
Jero J
No affiliation info available
Käyhty H
No affiliation info available
Karma P
No affiliation info available
Leinonen M
No affiliation info available
Eskola J
No affiliation info available

MeSH

Acute DiseaseAntibodies, BacterialBacterial CapsulesChildChild, PreschoolHumansImmunoenzyme TechniquesImmunoglobulin AImmunoglobulin GImmunoglobulin MInfantNasopharynxOtitis MediaStreptococcus pneumoniae

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

7561192

Citation

Virolainen, A, et al. "Nasopharyngeal Antibodies to Pneumococcal Capsular Polysaccharides in Children With Acute Otitis Media." The Journal of Infectious Diseases, vol. 172, no. 4, 1995, pp. 1115-8.
Virolainen A, Jero J, Käyhty H, et al. Nasopharyngeal antibodies to pneumococcal capsular polysaccharides in children with acute otitis media. J Infect Dis. 1995;172(4):1115-8.
Virolainen, A., Jero, J., Käyhty, H., Karma, P., Leinonen, M., & Eskola, J. (1995). Nasopharyngeal antibodies to pneumococcal capsular polysaccharides in children with acute otitis media. The Journal of Infectious Diseases, 172(4), 1115-8.
Virolainen A, et al. Nasopharyngeal Antibodies to Pneumococcal Capsular Polysaccharides in Children With Acute Otitis Media. J Infect Dis. 1995;172(4):1115-8. PubMed PMID: 7561192.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Nasopharyngeal antibodies to pneumococcal capsular polysaccharides in children with acute otitis media. AU - Virolainen,A, AU - Jero,J, AU - Käyhty,H, AU - Karma,P, AU - Leinonen,M, AU - Eskola,J, PY - 1995/10/1/pubmed PY - 1995/10/1/medline PY - 1995/10/1/entrez SP - 1115 EP - 8 JF - The Journal of infectious diseases JO - J Infect Dis VL - 172 IS - 4 N2 - Antibodies to pneumococcal capsular polysaccharides were measured by EIA in acute- and convalescent-phase nasopharyngeal aspirates from 120 children with acute otitis media. Nasopharyngeal IgM- and IgG-class antibodies were rare, whereas IgA was detected more often, occurred independently from serum IgA, and correlated with the presence of the secretory component in pneumococcal antibody, indicating local production of IgA. Thirty-four percent of the children with pneumococci in middle ear fluid developed a nasopharyngeal IgA response to the polysaccharide pool of serotypes 6B, 14, 19F, and 23F compared with 7% of the children with pneumococci only in the nasopharynx or not found at all (P = .004). The responses were observed in children of all ages, the youngest 6 months of age. This supports the hypothesis that mucosal immunity to bacterial polysaccharides matures earlier than systemic immunity. SN - 0022-1899 UR - https://www.unboundmedicine.com/medline/citation/7561192/Nasopharyngeal_antibodies_to_pneumococcal_capsular_polysaccharides_in_children_with_acute_otitis_media_ L2 - https://academic.oup.com/jid/article-lookup/doi/10.1093/infdis/172.4.1115 DB - PRIME DP - Unbound Medicine ER -