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In vitro activity of BAY y 3118, and nine other antimicrobial agents against anaerobic bacteria.
J Chemother. 1995 Jun; 7(3):189-96.JC

Abstract

The antibacterial activity of BAY y 3118, a new chlorofluoroquinolone, was determined against 257 strains of anaerobic bacteria and compared with the activities of ofloxacin, ciprofloxacin, sparfloxacin, imipenem, cefoxitin, clindamycin, chloramphenicol, metronidazole, and ornidazole. Overall, BAY y 3118 was the most active agent tested against the Bacteroides fragilis group. Its activity (MIC90, 0.5 mg/L) was 16-fold lower than that of sparfloxacin (MIC90, 8 mg/L), and more than 100-fold lower than that of ofloxacin (MIC90, 64 mg/L) and ciprofloxacin (MIC90, 128 mg/L) against the group. No strains belonging to this group were resistant to metronidazole (MICs range, 0.12-2 mg/L) and ornidazole (MICs range, 0.12-4 mg/L). BAY y 3118 was more active than those quinolones against Prevotella and Porphyromonas spp., Fusobacterium spp., Clostridium perfringens and C. difficile (MIC90, 0.12, 0.06, 0.12 and 0.25 mg/L, respectively). The activity of BAY y 3118 against Peptostreptococcus spp. (MIC90, 1 mg/L) was slightly lower than that of the other Gram-positive bacteria tested. In general, BAY y 3118 was more active than cefoxitin, and it was superior to antianaerobic chemical agents like metronidazole, ornidazole and clindamycin. Pharmacokinetic and clinical trials are required to define the role of BAY y 3118 in the treatment of anaerobic infections.

Authors+Show Affiliations

Department of Microbiology and Parasitology, Hospital Universitario-Facultad de Medicina, Salamanca, Spain.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

7562012

Citation

García-Rodríguez, J A., et al. "In Vitro Activity of BAY Y 3118, and Nine Other Antimicrobial Agents Against Anaerobic Bacteria." Journal of Chemotherapy (Florence, Italy), vol. 7, no. 3, 1995, pp. 189-96.
García-Rodríguez JA, García-Sánchez JE, Trujillano-Martín I, et al. In vitro activity of BAY y 3118, and nine other antimicrobial agents against anaerobic bacteria. J Chemother. 1995;7(3):189-96.
García-Rodríguez, J. A., García-Sánchez, J. E., Trujillano-Martín, I., García-Sánchez, E., García-García, M. I., & Fresnadillo-Martínez, M. J. (1995). In vitro activity of BAY y 3118, and nine other antimicrobial agents against anaerobic bacteria. Journal of Chemotherapy (Florence, Italy), 7(3), 189-96.
García-Rodríguez JA, et al. In Vitro Activity of BAY Y 3118, and Nine Other Antimicrobial Agents Against Anaerobic Bacteria. J Chemother. 1995;7(3):189-96. PubMed PMID: 7562012.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - In vitro activity of BAY y 3118, and nine other antimicrobial agents against anaerobic bacteria. AU - García-Rodríguez,J A, AU - García-Sánchez,J E, AU - Trujillano-Martín,I, AU - García-Sánchez,E, AU - García-García,M I, AU - Fresnadillo-Martínez,M J, PY - 1995/6/1/pubmed PY - 1995/6/1/medline PY - 1995/6/1/entrez SP - 189 EP - 96 JF - Journal of chemotherapy (Florence, Italy) JO - J Chemother VL - 7 IS - 3 N2 - The antibacterial activity of BAY y 3118, a new chlorofluoroquinolone, was determined against 257 strains of anaerobic bacteria and compared with the activities of ofloxacin, ciprofloxacin, sparfloxacin, imipenem, cefoxitin, clindamycin, chloramphenicol, metronidazole, and ornidazole. Overall, BAY y 3118 was the most active agent tested against the Bacteroides fragilis group. Its activity (MIC90, 0.5 mg/L) was 16-fold lower than that of sparfloxacin (MIC90, 8 mg/L), and more than 100-fold lower than that of ofloxacin (MIC90, 64 mg/L) and ciprofloxacin (MIC90, 128 mg/L) against the group. No strains belonging to this group were resistant to metronidazole (MICs range, 0.12-2 mg/L) and ornidazole (MICs range, 0.12-4 mg/L). BAY y 3118 was more active than those quinolones against Prevotella and Porphyromonas spp., Fusobacterium spp., Clostridium perfringens and C. difficile (MIC90, 0.12, 0.06, 0.12 and 0.25 mg/L, respectively). The activity of BAY y 3118 against Peptostreptococcus spp. (MIC90, 1 mg/L) was slightly lower than that of the other Gram-positive bacteria tested. In general, BAY y 3118 was more active than cefoxitin, and it was superior to antianaerobic chemical agents like metronidazole, ornidazole and clindamycin. Pharmacokinetic and clinical trials are required to define the role of BAY y 3118 in the treatment of anaerobic infections. SN - 1120-009X UR - https://www.unboundmedicine.com/medline/citation/7562012/In_vitro_activity_of_BAY_y_3118_and_nine_other_antimicrobial_agents_against_anaerobic_bacteria_ L2 - https://www.tandfonline.com/doi/full/10.1179/joc.1995.7.3.189 DB - PRIME DP - Unbound Medicine ER -