Tags

Type your tag names separated by a space and hit enter

Age-dependent sensitivity of rats to the long-term effects of the serotonergic neurotoxicant (+/-)-3,4-methylenedioxymethamphetamine (MDMA) correlates with the magnitude of the MDMA-induced thermal response.
J Pharmacol Exp Ther. 1995 Oct; 275(1):325-33.JP

Abstract

The effects of developmental age on (+/-)-3,4-methylenedioxymethamphetamine (MDMA)-induced reductions in 5-hydroxytryptamine (5-HT) content and 5-HT reuptake sites were investigated in conjunction with the effects of developmental age on MDMA-induced thermoregulatory responses. MDMA was administered to rats at postnatal days (PND) 10, 40 and 70 in a range of ambient temperature environments (10 degrees C, 25 degrees C and 33 degrees C). Animals were monitored for alterations in body temperature and sacrificed 1 week after MDMA administration. MDMA administration at PND 10 did not result in persistent reductions in 5-HT content or 5-HT reuptake sites in frontal cortex, nor could a hyperthermic response be elicited. In contrast, MDMA administration at PND 40 and PND 70 resulted in a hypothermic response in cold environments (10 degrees C) and a hyperthermic response in warm environments (> or = 25 degrees C). When hypothermia was observed after MDMA (10 degrees C environment), long-term reductions in 5-HT content and 5-HT reuptake sites were significantly attenuated or abolished. Conversely, when a hyperthermic response was observed (25 degrees C and 33 degrees C environments), long-term MDMA-induced reductions in 5-HT content and 5-HT reuptake sites were significantly enhanced. Thus, thermal responses significantly correlated with MDMA-induced reductions in 5-HT content and 5-HT reuptake sites. These experiments demonstrate a role for hyperthermia in the expression of serotonergic neurotoxicity after MDMA administration.

Authors+Show Affiliations

Interdisciplinary Toxicology Program, University of Arkansas for Medical Sciences, Little Rock, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

7562567

Citation

Broening, H W., et al. "Age-dependent Sensitivity of Rats to the Long-term Effects of the Serotonergic Neurotoxicant (+/-)-3,4-methylenedioxymethamphetamine (MDMA) Correlates With the Magnitude of the MDMA-induced Thermal Response." The Journal of Pharmacology and Experimental Therapeutics, vol. 275, no. 1, 1995, pp. 325-33.
Broening HW, Bowyer JF, Slikker W. Age-dependent sensitivity of rats to the long-term effects of the serotonergic neurotoxicant (+/-)-3,4-methylenedioxymethamphetamine (MDMA) correlates with the magnitude of the MDMA-induced thermal response. J Pharmacol Exp Ther. 1995;275(1):325-33.
Broening, H. W., Bowyer, J. F., & Slikker, W. (1995). Age-dependent sensitivity of rats to the long-term effects of the serotonergic neurotoxicant (+/-)-3,4-methylenedioxymethamphetamine (MDMA) correlates with the magnitude of the MDMA-induced thermal response. The Journal of Pharmacology and Experimental Therapeutics, 275(1), 325-33.
Broening HW, Bowyer JF, Slikker W. Age-dependent Sensitivity of Rats to the Long-term Effects of the Serotonergic Neurotoxicant (+/-)-3,4-methylenedioxymethamphetamine (MDMA) Correlates With the Magnitude of the MDMA-induced Thermal Response. J Pharmacol Exp Ther. 1995;275(1):325-33. PubMed PMID: 7562567.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Age-dependent sensitivity of rats to the long-term effects of the serotonergic neurotoxicant (+/-)-3,4-methylenedioxymethamphetamine (MDMA) correlates with the magnitude of the MDMA-induced thermal response. AU - Broening,H W, AU - Bowyer,J F, AU - Slikker,W,Jr PY - 1995/10/1/pubmed PY - 2001/3/28/medline PY - 1995/10/1/entrez SP - 325 EP - 33 JF - The Journal of pharmacology and experimental therapeutics JO - J. Pharmacol. Exp. Ther. VL - 275 IS - 1 N2 - The effects of developmental age on (+/-)-3,4-methylenedioxymethamphetamine (MDMA)-induced reductions in 5-hydroxytryptamine (5-HT) content and 5-HT reuptake sites were investigated in conjunction with the effects of developmental age on MDMA-induced thermoregulatory responses. MDMA was administered to rats at postnatal days (PND) 10, 40 and 70 in a range of ambient temperature environments (10 degrees C, 25 degrees C and 33 degrees C). Animals were monitored for alterations in body temperature and sacrificed 1 week after MDMA administration. MDMA administration at PND 10 did not result in persistent reductions in 5-HT content or 5-HT reuptake sites in frontal cortex, nor could a hyperthermic response be elicited. In contrast, MDMA administration at PND 40 and PND 70 resulted in a hypothermic response in cold environments (10 degrees C) and a hyperthermic response in warm environments (> or = 25 degrees C). When hypothermia was observed after MDMA (10 degrees C environment), long-term reductions in 5-HT content and 5-HT reuptake sites were significantly attenuated or abolished. Conversely, when a hyperthermic response was observed (25 degrees C and 33 degrees C environments), long-term MDMA-induced reductions in 5-HT content and 5-HT reuptake sites were significantly enhanced. Thus, thermal responses significantly correlated with MDMA-induced reductions in 5-HT content and 5-HT reuptake sites. These experiments demonstrate a role for hyperthermia in the expression of serotonergic neurotoxicity after MDMA administration. SN - 0022-3565 UR - https://www.unboundmedicine.com/medline/citation/7562567/Age_dependent_sensitivity_of_rats_to_the_long_term_effects_of_the_serotonergic_neurotoxicant__+/___34_methylenedioxymethamphetamine__MDMA__correlates_with_the_magnitude_of_the_MDMA_induced_thermal_response_ L2 - http://jpet.aspetjournals.org/cgi/pmidlookup?view=long&pmid=7562567 DB - PRIME DP - Unbound Medicine ER -