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Sex chromosome tetrasomy and pentasomy.
Pediatrics. 1995 Oct; 96(4 Pt 1):672-82.Ped

Abstract

Sex chromosome abnormalities occur in at least 1 in 400 births and include the well-described 47,XXX, 47,XXY, 47,XYY, and 45,X karyotypes. The addition of more than one extra X or Y chromosome occurs rarely, and little information is available in the medical literature. Individual case reports make up most of this body of knowledge, and all are based on subjects who identified themselves postnatally. Many were ascertained through screenings of institutions and hospitals; thus, there is no unbiased information on the natural history of poly X and Y karyotypes. A direct relationship between the number of additional sex chromosomes and the severity of the phenotype is generally assumed. The purpose of this article is to summarize what is known about these conditions and to present 10 additional cases. The karyotypes include, 48,XXXX, 49,XXXXX, 48,XXYY, 48,XXXY, 49,XXXXY, 49,XXXYY, 48,XYYY, 49,XYYYY, and 49,XXYYY.

Authors+Show Affiliations

Department of Pediatrics, National Jewish Center for Immunology and Respiratory Medicine, Denver, CO 80206, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article
Research Support, U.S. Gov't, P.H.S.
Review

Language

eng

PubMed ID

7567329

Citation

Linden, M G., et al. "Sex Chromosome Tetrasomy and Pentasomy." Pediatrics, vol. 96, no. 4 Pt 1, 1995, pp. 672-82.
Linden MG, Bender BG, Robinson A. Sex chromosome tetrasomy and pentasomy. Pediatrics. 1995;96(4 Pt 1):672-82.
Linden, M. G., Bender, B. G., & Robinson, A. (1995). Sex chromosome tetrasomy and pentasomy. Pediatrics, 96(4 Pt 1), 672-82.
Linden MG, Bender BG, Robinson A. Sex Chromosome Tetrasomy and Pentasomy. Pediatrics. 1995;96(4 Pt 1):672-82. PubMed PMID: 7567329.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Sex chromosome tetrasomy and pentasomy. AU - Linden,M G, AU - Bender,B G, AU - Robinson,A, PY - 1995/10/1/pubmed PY - 1995/10/1/medline PY - 1995/10/1/entrez SP - 672 EP - 82 JF - Pediatrics JO - Pediatrics VL - 96 IS - 4 Pt 1 N2 - Sex chromosome abnormalities occur in at least 1 in 400 births and include the well-described 47,XXX, 47,XXY, 47,XYY, and 45,X karyotypes. The addition of more than one extra X or Y chromosome occurs rarely, and little information is available in the medical literature. Individual case reports make up most of this body of knowledge, and all are based on subjects who identified themselves postnatally. Many were ascertained through screenings of institutions and hospitals; thus, there is no unbiased information on the natural history of poly X and Y karyotypes. A direct relationship between the number of additional sex chromosomes and the severity of the phenotype is generally assumed. The purpose of this article is to summarize what is known about these conditions and to present 10 additional cases. The karyotypes include, 48,XXXX, 49,XXXXX, 48,XXYY, 48,XXXY, 49,XXXXY, 49,XXXYY, 48,XYYY, 49,XYYYY, and 49,XXYYY. SN - 0031-4005 UR - https://www.unboundmedicine.com/medline/citation/7567329/Sex_chromosome_tetrasomy_and_pentasomy_ L2 - http://pediatrics.aappublications.org/cgi/pmidlookup?view=long&pmid=7567329 DB - PRIME DP - Unbound Medicine ER -