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Analysis of false results in a series of 835 fine needle aspirates of breast lesions.
Acta Cytol. 1995 Sep-Oct; 39(5):858-64.AC

Abstract

OBJECTIVE

To analyze cases of false diagnoses from a large series to help increase the accuracy of fine needle aspiration of palpable breast lesions.

STUDY DESIGN

The results of FNA of 835 palpable breast lesions were analyzed to determine the reasons for false positive, false negative and false suspicious diagnoses.

RESULTS

Of the 835 aspirates, 174 were reported as positive, 549 as negative and 66 as suspicious or atypical but not diagnostic of malignancy. Forty-six cases were considered unsatisfactory. Tissue was available for comparison in 286 cases. The cytologic diagnoses in these cases were reported as follows: positive, 125 (43.7%); suspicious, 33 (11.5%); atypical, 18 (6.2%); negative, 92 (32%); and unsatisfactory, 18 (6.2%). There was one false positive diagnosis, yielding a false positive rate of 0.8%. This lesion was a case of fibrocystic change with hyperplasia, focal fat necrosis and reparative atypia. There were 14 false negative cases, resulting in a false negative rate of 13.2%. Nearly all these cases were sampling errors and included infiltrating ductal carcinomas (9), ductal carcinomas in situ (2), infiltrating lobular carcinomas (2) and tubular carcinoma (1). Most of the suspicious and atypical lesions proved to be carcinomas (35/50). The remainder were fibroadenomas (6), fibrocystic change (4), gynecomastia (2), adenosis (2) and granulomatous mastitis (1).

CONCLUSION

A positive diagnosis of malignancy by FNA is reliable in establishing the diagnosis and planning the treatment of breast cancer. The false-positive rate is very low, with only a single case reported in 835 aspirates. Most false negatives are due to sampling and not to interpretive difficulties. The category "suspicious but not diagnostic of malignancy" serves a useful purpose in management of patients with breast lumps.

Authors+Show Affiliations

Department of Pathology, Baylor College of Medicine, Houston, Texas 77030, USA.No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

7571960

Citation

Willis, S L., and I Ramzy. "Analysis of False Results in a Series of 835 Fine Needle Aspirates of Breast Lesions." Acta Cytologica, vol. 39, no. 5, 1995, pp. 858-64.
Willis SL, Ramzy I. Analysis of false results in a series of 835 fine needle aspirates of breast lesions. Acta Cytol. 1995;39(5):858-64.
Willis, S. L., & Ramzy, I. (1995). Analysis of false results in a series of 835 fine needle aspirates of breast lesions. Acta Cytologica, 39(5), 858-64.
Willis SL, Ramzy I. Analysis of False Results in a Series of 835 Fine Needle Aspirates of Breast Lesions. Acta Cytol. 1995 Sep-Oct;39(5):858-64. PubMed PMID: 7571960.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Analysis of false results in a series of 835 fine needle aspirates of breast lesions. AU - Willis,S L, AU - Ramzy,I, PY - 1995/9/1/pubmed PY - 1995/9/1/medline PY - 1995/9/1/entrez SP - 858 EP - 64 JF - Acta cytologica JO - Acta Cytol VL - 39 IS - 5 N2 - OBJECTIVE: To analyze cases of false diagnoses from a large series to help increase the accuracy of fine needle aspiration of palpable breast lesions. STUDY DESIGN: The results of FNA of 835 palpable breast lesions were analyzed to determine the reasons for false positive, false negative and false suspicious diagnoses. RESULTS: Of the 835 aspirates, 174 were reported as positive, 549 as negative and 66 as suspicious or atypical but not diagnostic of malignancy. Forty-six cases were considered unsatisfactory. Tissue was available for comparison in 286 cases. The cytologic diagnoses in these cases were reported as follows: positive, 125 (43.7%); suspicious, 33 (11.5%); atypical, 18 (6.2%); negative, 92 (32%); and unsatisfactory, 18 (6.2%). There was one false positive diagnosis, yielding a false positive rate of 0.8%. This lesion was a case of fibrocystic change with hyperplasia, focal fat necrosis and reparative atypia. There were 14 false negative cases, resulting in a false negative rate of 13.2%. Nearly all these cases were sampling errors and included infiltrating ductal carcinomas (9), ductal carcinomas in situ (2), infiltrating lobular carcinomas (2) and tubular carcinoma (1). Most of the suspicious and atypical lesions proved to be carcinomas (35/50). The remainder were fibroadenomas (6), fibrocystic change (4), gynecomastia (2), adenosis (2) and granulomatous mastitis (1). CONCLUSION: A positive diagnosis of malignancy by FNA is reliable in establishing the diagnosis and planning the treatment of breast cancer. The false-positive rate is very low, with only a single case reported in 835 aspirates. Most false negatives are due to sampling and not to interpretive difficulties. The category "suspicious but not diagnostic of malignancy" serves a useful purpose in management of patients with breast lumps. SN - 0001-5547 UR - https://www.unboundmedicine.com/medline/citation/7571960/Analysis_of_false_results_in_a_series_of_835_fine_needle_aspirates_of_breast_lesions_ L2 - https://medlineplus.gov/breastcancer.html DB - PRIME DP - Unbound Medicine ER -