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Cytologic diagnosis of ductal versus lobular carcinoma of the breast.
Acta Cytol. 1995 Sep-Oct; 39(5):865-9.AC

Abstract

OBJECTIVE

To determine the value of cytology in the differential diagnosis of ductal versus lobular carcinoma of the breast.

STUDY DESIGN

In this study we examined 11 cytologic parameters in fine needle aspiration (FNA) cytology specimens from 52 patients who underwent surgery and had subsequent histologic diagnoses. Eighty-eight percent (46 cases) were infiltrating ductal carcinoma, and 12% (6 cases) were invasive lobular carcinoma.

RESULTS

Of the 11 cytologic parameters only chromatin pattern (P < .0001), nuclear size (P < .004) and overall cell size (P < .004) showed statistically significant differences between the two groups. Nuclear chromatin was coarsely granular only in cases of ductal carcinoma, while fine granularity could be seen in both ductal and lobular tumors. An automated morphometric system was used to determine the nuclear and overall cell size. The granularity of nuclear chromatin in ductal carcinoma cells did not correlate significantly with nuclear and overall cell size; therefore, they should be considered independent cytologic parameters.

CONCLUSION

The cytologic differential diagnosis of ductal versus lobular carcinoma is difficult; based on this study, the presence of coarsely granular chromatin, nuclear size > 44 microns2 and cell size > 82 microns2 are the only features diagnostic of ductal versus lobular carcinoma.

Authors+Show Affiliations

Mallory Institute of Pathology, Boston University School of Medicine, Massachusetts 02118, USA.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

7571961

Citation

de las Morenas, A, et al. "Cytologic Diagnosis of Ductal Versus Lobular Carcinoma of the Breast." Acta Cytologica, vol. 39, no. 5, 1995, pp. 865-9.
de las Morenas A, Crespo P, Moroz K, et al. Cytologic diagnosis of ductal versus lobular carcinoma of the breast. Acta Cytol. 1995;39(5):865-9.
de las Morenas, A., Crespo, P., Moroz, K., & Donnelly, M. M. (1995). Cytologic diagnosis of ductal versus lobular carcinoma of the breast. Acta Cytologica, 39(5), 865-9.
de las Morenas A, et al. Cytologic Diagnosis of Ductal Versus Lobular Carcinoma of the Breast. Acta Cytol. 1995 Sep-Oct;39(5):865-9. PubMed PMID: 7571961.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cytologic diagnosis of ductal versus lobular carcinoma of the breast. AU - de las Morenas,A, AU - Crespo,P, AU - Moroz,K, AU - Donnelly,M M, PY - 1995/9/1/pubmed PY - 1995/9/1/medline PY - 1995/9/1/entrez SP - 865 EP - 9 JF - Acta cytologica JO - Acta Cytol VL - 39 IS - 5 N2 - OBJECTIVE: To determine the value of cytology in the differential diagnosis of ductal versus lobular carcinoma of the breast. STUDY DESIGN: In this study we examined 11 cytologic parameters in fine needle aspiration (FNA) cytology specimens from 52 patients who underwent surgery and had subsequent histologic diagnoses. Eighty-eight percent (46 cases) were infiltrating ductal carcinoma, and 12% (6 cases) were invasive lobular carcinoma. RESULTS: Of the 11 cytologic parameters only chromatin pattern (P < .0001), nuclear size (P < .004) and overall cell size (P < .004) showed statistically significant differences between the two groups. Nuclear chromatin was coarsely granular only in cases of ductal carcinoma, while fine granularity could be seen in both ductal and lobular tumors. An automated morphometric system was used to determine the nuclear and overall cell size. The granularity of nuclear chromatin in ductal carcinoma cells did not correlate significantly with nuclear and overall cell size; therefore, they should be considered independent cytologic parameters. CONCLUSION: The cytologic differential diagnosis of ductal versus lobular carcinoma is difficult; based on this study, the presence of coarsely granular chromatin, nuclear size > 44 microns2 and cell size > 82 microns2 are the only features diagnostic of ductal versus lobular carcinoma. SN - 0001-5547 UR - https://www.unboundmedicine.com/medline/citation/7571961/Cytologic_diagnosis_of_ductal_versus_lobular_carcinoma_of_the_breast_ L2 - https://medlineplus.gov/breastcancer.html DB - PRIME DP - Unbound Medicine ER -