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Vitamin D receptor alleles and rates of bone loss: influences of years since menopause and calcium intake.
J Bone Miner Res. 1995 Jun; 10(6):978-84.JB

Abstract

A genetic marker for the 1,25-dihydroxyvitamin D receptor (VDR) is reported to account for much of the heritable component of bone density. It is not known whether VDR genotype influences bone accretion or loss, or how it is related to calcium metabolism. The VDR genotype was determined in 229 healthy postmenopausal women who previously participated in a calcium trial. VDR alleles were designated according to presence (b) or absence (B) of the BsmI restriction enzyme cutting site. There were 83 bb, 102 Bb, and 44 BB individuals. Two-thirds of the women took 500 mg of calcium supplement (mean calcium intake = 892 mg/day) and one-third a placebo (mean = 376 mg/day). Bone mineral density (BMD) at the femoral neck, spine, and radius were measured by dual- and single-photon absorptiometry at baseline and after 1 and 2 years. Among women more than 10 years postmenopausal, those with the BB genotype had the lowest femoral neck BMD. Rates of bone loss over 2 years were greater in the BB group at all sites (e.g., at the femoral neck, bb, 0.45 +/- 0.43; Bb, -0.01 +/- 0.40; BB, -0.99 +/- 0.50%/year; BB vs. bb, p = 0.01), and this trend was found both in women < 10 years since menopause (e.g., at the radius, bb, 0.43 +/- 0.47; Bb, -0.37 +/- 0.42; BB, -1.20 +/- 0.59% per year; BB vs. bb, p = 0.02) and those > or = 10 years (radius, bb, -0.71 +/- 0.41; Bb, 0.08 +/- 0.39; BB, -1.41 +/- 0.49% per year; BB vs. Bb, p < 0.01).(

ABSTRACT

TRUNCATED AT 250 WORDS)

Authors+Show Affiliations

Calcium and Bone Metabolism Laboratory, USDA Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts, USA.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

7572323

Citation

Krall, E A., et al. "Vitamin D Receptor Alleles and Rates of Bone Loss: Influences of Years Since Menopause and Calcium Intake." Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research, vol. 10, no. 6, 1995, pp. 978-84.
Krall EA, Parry P, Lichter JB, et al. Vitamin D receptor alleles and rates of bone loss: influences of years since menopause and calcium intake. J Bone Miner Res. 1995;10(6):978-84.
Krall, E. A., Parry, P., Lichter, J. B., & Dawson-Hughes, B. (1995). Vitamin D receptor alleles and rates of bone loss: influences of years since menopause and calcium intake. Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research, 10(6), 978-84.
Krall EA, et al. Vitamin D Receptor Alleles and Rates of Bone Loss: Influences of Years Since Menopause and Calcium Intake. J Bone Miner Res. 1995;10(6):978-84. PubMed PMID: 7572323.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vitamin D receptor alleles and rates of bone loss: influences of years since menopause and calcium intake. AU - Krall,E A, AU - Parry,P, AU - Lichter,J B, AU - Dawson-Hughes,B, PY - 1995/6/1/pubmed PY - 1995/6/1/medline PY - 1995/6/1/entrez SP - 978 EP - 84 JF - Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research JO - J Bone Miner Res VL - 10 IS - 6 N2 - A genetic marker for the 1,25-dihydroxyvitamin D receptor (VDR) is reported to account for much of the heritable component of bone density. It is not known whether VDR genotype influences bone accretion or loss, or how it is related to calcium metabolism. The VDR genotype was determined in 229 healthy postmenopausal women who previously participated in a calcium trial. VDR alleles were designated according to presence (b) or absence (B) of the BsmI restriction enzyme cutting site. There were 83 bb, 102 Bb, and 44 BB individuals. Two-thirds of the women took 500 mg of calcium supplement (mean calcium intake = 892 mg/day) and one-third a placebo (mean = 376 mg/day). Bone mineral density (BMD) at the femoral neck, spine, and radius were measured by dual- and single-photon absorptiometry at baseline and after 1 and 2 years. Among women more than 10 years postmenopausal, those with the BB genotype had the lowest femoral neck BMD. Rates of bone loss over 2 years were greater in the BB group at all sites (e.g., at the femoral neck, bb, 0.45 +/- 0.43; Bb, -0.01 +/- 0.40; BB, -0.99 +/- 0.50%/year; BB vs. bb, p = 0.01), and this trend was found both in women < 10 years since menopause (e.g., at the radius, bb, 0.43 +/- 0.47; Bb, -0.37 +/- 0.42; BB, -1.20 +/- 0.59% per year; BB vs. bb, p = 0.02) and those > or = 10 years (radius, bb, -0.71 +/- 0.41; Bb, 0.08 +/- 0.39; BB, -1.41 +/- 0.49% per year; BB vs. Bb, p < 0.01).(ABSTRACT TRUNCATED AT 250 WORDS) SN - 0884-0431 UR - https://www.unboundmedicine.com/medline/citation/7572323/Vitamin_D_receptor_alleles_and_rates_of_bone_loss:_influences_of_years_since_menopause_and_calcium_intake_ L2 - https://doi.org/10.1002/jbmr.5650100620 DB - PRIME DP - Unbound Medicine ER -