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The contribution of vitamin D receptor gene alleles to the determination of bone mineral density in normal and osteoporotic women.
J Bone Miner Res. 1995 Jun; 10(6):991-6.JB

Abstract

Bone mass and its mineral content are under genetic control. The vitamin D receptor (VDR) gene has been shown to be a major locus for genetic effects on bone mineral density (BMD), and polymorphisms in this gene accounted for a large proportion of genetic variance in BMD in an Australian population. In this study, we investigated whether similar associations are present in a North American population. We studied 139 normal healthy women (age 53.2 +/- 14.5, mean +/- SD) and 43 severely osteoporotic postmenopausal women (age 65.8 +/- 5.9). In the 127 of them with complete genetic studies, the distribution of genotypes, determined by polymerase chain reaction on leukocyte DNA samples, agreed closely with that in the Australian population. BMD was strongly related to age and weight, and, thus was adjusted for these parameters prior to genetic analysis. We found that age modulated the effect of VDR genotypes on femoral neck BMD (FN-BMD) (TaqI, p = 0.036; BsmI, p = 0.118; ApaI, p = 0.041) such that the effect of genotype was greatest among younger (premenopausal) women and declined with age so that there was no discernible difference by age 70. Among the younger women, a high FN-BMD was associated with the TT (or aa or bb) genotype while low FN-BMD was associated with the tt (or AA or BB) genotype.(

ABSTRACT

TRUNCATED AT 250 WORDS)

Authors+Show Affiliations

Endocrine Research Unit, Mayo Clinic, Rochester, Minnesota, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

7572325

Citation

Riggs, B L., et al. "The Contribution of Vitamin D Receptor Gene Alleles to the Determination of Bone Mineral Density in Normal and Osteoporotic Women." Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research, vol. 10, no. 6, 1995, pp. 991-6.
Riggs BL, Nguyen TV, Melton LJ, et al. The contribution of vitamin D receptor gene alleles to the determination of bone mineral density in normal and osteoporotic women. J Bone Miner Res. 1995;10(6):991-6.
Riggs, B. L., Nguyen, T. V., Melton, L. J., Morrison, N. A., O'Fallon, W. M., Kelly, P. J., Egan, K. S., Sambrook, P. N., Muhs, J. M., & Eisman, J. A. (1995). The contribution of vitamin D receptor gene alleles to the determination of bone mineral density in normal and osteoporotic women. Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research, 10(6), 991-6.
Riggs BL, et al. The Contribution of Vitamin D Receptor Gene Alleles to the Determination of Bone Mineral Density in Normal and Osteoporotic Women. J Bone Miner Res. 1995;10(6):991-6. PubMed PMID: 7572325.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The contribution of vitamin D receptor gene alleles to the determination of bone mineral density in normal and osteoporotic women. AU - Riggs,B L, AU - Nguyen,T V, AU - Melton,L J,3rd AU - Morrison,N A, AU - O'Fallon,W M, AU - Kelly,P J, AU - Egan,K S, AU - Sambrook,P N, AU - Muhs,J M, AU - Eisman,J A, PY - 1995/6/1/pubmed PY - 2001/3/28/medline PY - 1995/6/1/entrez SP - 991 EP - 6 JF - Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research JO - J Bone Miner Res VL - 10 IS - 6 N2 - Bone mass and its mineral content are under genetic control. The vitamin D receptor (VDR) gene has been shown to be a major locus for genetic effects on bone mineral density (BMD), and polymorphisms in this gene accounted for a large proportion of genetic variance in BMD in an Australian population. In this study, we investigated whether similar associations are present in a North American population. We studied 139 normal healthy women (age 53.2 +/- 14.5, mean +/- SD) and 43 severely osteoporotic postmenopausal women (age 65.8 +/- 5.9). In the 127 of them with complete genetic studies, the distribution of genotypes, determined by polymerase chain reaction on leukocyte DNA samples, agreed closely with that in the Australian population. BMD was strongly related to age and weight, and, thus was adjusted for these parameters prior to genetic analysis. We found that age modulated the effect of VDR genotypes on femoral neck BMD (FN-BMD) (TaqI, p = 0.036; BsmI, p = 0.118; ApaI, p = 0.041) such that the effect of genotype was greatest among younger (premenopausal) women and declined with age so that there was no discernible difference by age 70. Among the younger women, a high FN-BMD was associated with the TT (or aa or bb) genotype while low FN-BMD was associated with the tt (or AA or BB) genotype.(ABSTRACT TRUNCATED AT 250 WORDS) SN - 0884-0431 UR - https://www.unboundmedicine.com/medline/citation/7572325/The_contribution_of_vitamin_D_receptor_gene_alleles_to_the_determination_of_bone_mineral_density_in_normal_and_osteoporotic_women_ L2 - https://doi.org/10.1002/jbmr.5650100622 DB - PRIME DP - Unbound Medicine ER -