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The CYP2D6B allele is associated with a milder synaptic pathology in Alzheimer's disease.
Ann Neurol. 1995 Oct; 38(4):653-8.AN

Abstract

Both genetic and environmental factors affect the progression of Alzheimer's disease (AD). The presence of cortical Lewy bodies in AD patients is associated with an altered presentation of AD pathology suggestive of an interaction between the pathogenesis of Lewy bodies and AD lesions. Since the CYP2D6B mutant allele is often present in patients with Lewy body diseases (Parkinson's disease and Lewy body variant of AD), we extended these prior observations by studying the neuropathology associated with the presence of the CYP2D6B mutant allele in a pure AD population without Lewy bodies. AD patients who possessed the CYP2D6B mutant allele, in comparison with those without the CYP2D6B allele, were found to have a smaller decline in two synaptic markers, choline acetyltransferase and synaptophysin, in the frontal cortex relative to normal control values. On the other hand, senile plaques and neurofibrillary tangles were not significantly affected by the presence of the CYP2D6B mutant allele in the frontal cortex of AD patients. Association of the CYP2D6B mutant allele with Lewy body formation in both Parkinson's disease and the Lewy body variant of AD and with the milder synaptic pathology in pure AD without Lewy bodies suggest that depending on the contribution of other genetic and environmental factors, this mutant allele may be involved with different aspects of neurodegeneration.

Authors+Show Affiliations

Department of Neurosciences, University of California at San Diego, La Jolla 92093-0624, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

7574463

Citation

Chen, X, et al. "The CYP2D6B Allele Is Associated With a Milder Synaptic Pathology in Alzheimer's Disease." Annals of Neurology, vol. 38, no. 4, 1995, pp. 653-8.
Chen X, Xia Y, Alford M, et al. The CYP2D6B allele is associated with a milder synaptic pathology in Alzheimer's disease. Ann Neurol. 1995;38(4):653-8.
Chen, X., Xia, Y., Alford, M., DeTeresa, R., Hansen, L., Klauber, M. R., Katzman, R., Thal, L., Masliah, E., & Saitoh, T. (1995). The CYP2D6B allele is associated with a milder synaptic pathology in Alzheimer's disease. Annals of Neurology, 38(4), 653-8.
Chen X, et al. The CYP2D6B Allele Is Associated With a Milder Synaptic Pathology in Alzheimer's Disease. Ann Neurol. 1995;38(4):653-8. PubMed PMID: 7574463.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The CYP2D6B allele is associated with a milder synaptic pathology in Alzheimer's disease. AU - Chen,X, AU - Xia,Y, AU - Alford,M, AU - DeTeresa,R, AU - Hansen,L, AU - Klauber,M R, AU - Katzman,R, AU - Thal,L, AU - Masliah,E, AU - Saitoh,T, PY - 1995/10/1/pubmed PY - 1995/10/1/medline PY - 1995/10/1/entrez SP - 653 EP - 8 JF - Annals of neurology JO - Ann Neurol VL - 38 IS - 4 N2 - Both genetic and environmental factors affect the progression of Alzheimer's disease (AD). The presence of cortical Lewy bodies in AD patients is associated with an altered presentation of AD pathology suggestive of an interaction between the pathogenesis of Lewy bodies and AD lesions. Since the CYP2D6B mutant allele is often present in patients with Lewy body diseases (Parkinson's disease and Lewy body variant of AD), we extended these prior observations by studying the neuropathology associated with the presence of the CYP2D6B mutant allele in a pure AD population without Lewy bodies. AD patients who possessed the CYP2D6B mutant allele, in comparison with those without the CYP2D6B allele, were found to have a smaller decline in two synaptic markers, choline acetyltransferase and synaptophysin, in the frontal cortex relative to normal control values. On the other hand, senile plaques and neurofibrillary tangles were not significantly affected by the presence of the CYP2D6B mutant allele in the frontal cortex of AD patients. Association of the CYP2D6B mutant allele with Lewy body formation in both Parkinson's disease and the Lewy body variant of AD and with the milder synaptic pathology in pure AD without Lewy bodies suggest that depending on the contribution of other genetic and environmental factors, this mutant allele may be involved with different aspects of neurodegeneration. SN - 0364-5134 UR - https://www.unboundmedicine.com/medline/citation/7574463/The_CYP2D6B_allele_is_associated_with_a_milder_synaptic_pathology_in_Alzheimer's_disease_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0364-5134&date=1995&volume=38&issue=4&spage=653 DB - PRIME DP - Unbound Medicine ER -