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[Serum antigliadin antibodies in the diagnosis and follow-up of celiac disease].
Arq Gastroenterol. 1994 Oct-Dec; 31(4):154-8.AG

Abstract

Between July 1985 and June 1990, we prospectively investigated 236 children suspected of having malabsorption syndrome. Each patient had a xylose absorption test and small intestinal biopsy. Blood samples were collected to AGA assay. The aim of the study was to evaluate the use of antigliadin antibodies test, IgG and IgA, in screening celiac disease for intestinal biopsy and in the monitoring of gluten-free diet and challenge in celiac patients. Twenty patients were diagnosed with celiac disease confirmed by three small intestinal biopsies; 12 patients were suspected of having celiac disease, with two biopsies, before and one year after a gluten-free diet; 106 patients had environmental enteropathy; 45 patients had protracted diarrhea and 56 children had failure to thrive with no gastrointestinal symptoms. The AGA test was considered a reliable test in screening for biopsy and in the differential diagnosis between celiac disease and other causes of malabsorption syndrome. The IgG AGA test had high sensitivity (90.4%) and the IgA AGA test had high specificity (92.1%) in screening for celiac disease. In the follow-up of the celiac patients the antibody levels were significantly higher during gluten containing diet than after gluten avoidance being thus a reliable test to evaluate dietary compliance.

Authors+Show Affiliations

Escola Paulista de Medicina, São Paulo.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
English Abstract
Journal Article

Language

por

PubMed ID

7575176

Citation

Medeiros, E H., et al. "[Serum Antigliadin Antibodies in the Diagnosis and Follow-up of Celiac Disease]." Arquivos De Gastroenterologia, vol. 31, no. 4, 1994, pp. 154-8.
Medeiros EH, Patrício FR, de Morais MB, et al. [Serum antigliadin antibodies in the diagnosis and follow-up of celiac disease]. Arq Gastroenterol. 1994;31(4):154-8.
Medeiros, E. H., Patrício, F. R., de Morais, M. B., Leser, P. G., & Wehba, J. (1994). [Serum antigliadin antibodies in the diagnosis and follow-up of celiac disease]. Arquivos De Gastroenterologia, 31(4), 154-8.
Medeiros EH, et al. [Serum Antigliadin Antibodies in the Diagnosis and Follow-up of Celiac Disease]. Arq Gastroenterol. 1994;31(4):154-8. PubMed PMID: 7575176.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Serum antigliadin antibodies in the diagnosis and follow-up of celiac disease]. AU - Medeiros,E H, AU - Patrício,F R, AU - de Morais,M B, AU - Leser,P G, AU - Wehba,J, PY - 1994/10/1/pubmed PY - 1994/10/1/medline PY - 1994/10/1/entrez SP - 154 EP - 8 JF - Arquivos de gastroenterologia JO - Arq Gastroenterol VL - 31 IS - 4 N2 - Between July 1985 and June 1990, we prospectively investigated 236 children suspected of having malabsorption syndrome. Each patient had a xylose absorption test and small intestinal biopsy. Blood samples were collected to AGA assay. The aim of the study was to evaluate the use of antigliadin antibodies test, IgG and IgA, in screening celiac disease for intestinal biopsy and in the monitoring of gluten-free diet and challenge in celiac patients. Twenty patients were diagnosed with celiac disease confirmed by three small intestinal biopsies; 12 patients were suspected of having celiac disease, with two biopsies, before and one year after a gluten-free diet; 106 patients had environmental enteropathy; 45 patients had protracted diarrhea and 56 children had failure to thrive with no gastrointestinal symptoms. The AGA test was considered a reliable test in screening for biopsy and in the differential diagnosis between celiac disease and other causes of malabsorption syndrome. The IgG AGA test had high sensitivity (90.4%) and the IgA AGA test had high specificity (92.1%) in screening for celiac disease. In the follow-up of the celiac patients the antibody levels were significantly higher during gluten containing diet than after gluten avoidance being thus a reliable test to evaluate dietary compliance. SN - 0004-2803 UR - https://www.unboundmedicine.com/medline/citation/7575176/[Serum_antigliadin_antibodies_in_the_diagnosis_and_follow_up_of_celiac_disease]_ L2 - http://www.diseaseinfosearch.org/result/1186 DB - PRIME DP - Unbound Medicine ER -