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Variations in composition of dietary fats affect hepatic uptake and metabolism of chylomicron remnants.
Biochem J. 1995 Sep 15; 310 (Pt 3):845-52.BJ

Abstract

The hepatic metabolism of [1-14C]oleate- and [1,2-3H]cholesterol-dual-labelled chylomicron remnants derived from olive, corn, palm and fish oil and butter fat was compared by adding each lipoprotein separately to the perfusate of isolated livers from rats fed on a normal diet. Labelled remnants from butter fat and fish oil were removed more rapidly from the perfusate than remnants derived from olive, corn and palm oil. The oxidation of labelled remnant fatty acid from olive oil, fish oil or butter fat was four to seven times greater than that from corn and palm oil. Labelled fatty acid in fish oil remnants was incorporated into phospholipid significantly more efficiently than the labelled fatty acid in olive, corn or palm oil remnants, with butter fat giving an intermediate value. For all the remnants, there was a significant amount of hydrolysis of labelled esterified cholesterol by the liver which was dependent on the magnitude of hepatic uptake of each type of remnant. The recovery of remnant [3H]cholesterol label in the bile was 50% less with palm oil remnants than with all the other remnants studied. The results indicate that the fatty acid composition of chylomicron remnants has a major impact on their uptake and metabolism by the liver.

Authors+Show Affiliations

Department of Veterinary Basic Science, Royal Veterinary College, University of London, UK.No affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

7575417

Citation

Lambert, M S., et al. "Variations in Composition of Dietary Fats Affect Hepatic Uptake and Metabolism of Chylomicron Remnants." The Biochemical Journal, vol. 310 (Pt 3), 1995, pp. 845-52.
Lambert MS, Botham KM, Mayes PA. Variations in composition of dietary fats affect hepatic uptake and metabolism of chylomicron remnants. Biochem J. 1995;310 (Pt 3):845-52.
Lambert, M. S., Botham, K. M., & Mayes, P. A. (1995). Variations in composition of dietary fats affect hepatic uptake and metabolism of chylomicron remnants. The Biochemical Journal, 310 (Pt 3), 845-52.
Lambert MS, Botham KM, Mayes PA. Variations in Composition of Dietary Fats Affect Hepatic Uptake and Metabolism of Chylomicron Remnants. Biochem J. 1995 Sep 15;310 (Pt 3):845-52. PubMed PMID: 7575417.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Variations in composition of dietary fats affect hepatic uptake and metabolism of chylomicron remnants. AU - Lambert,M S, AU - Botham,K M, AU - Mayes,P A, PY - 1995/9/15/pubmed PY - 1995/9/15/medline PY - 1995/9/15/entrez SP - 845 EP - 52 JF - The Biochemical journal JO - Biochem. J. VL - 310 (Pt 3) N2 - The hepatic metabolism of [1-14C]oleate- and [1,2-3H]cholesterol-dual-labelled chylomicron remnants derived from olive, corn, palm and fish oil and butter fat was compared by adding each lipoprotein separately to the perfusate of isolated livers from rats fed on a normal diet. Labelled remnants from butter fat and fish oil were removed more rapidly from the perfusate than remnants derived from olive, corn and palm oil. The oxidation of labelled remnant fatty acid from olive oil, fish oil or butter fat was four to seven times greater than that from corn and palm oil. Labelled fatty acid in fish oil remnants was incorporated into phospholipid significantly more efficiently than the labelled fatty acid in olive, corn or palm oil remnants, with butter fat giving an intermediate value. For all the remnants, there was a significant amount of hydrolysis of labelled esterified cholesterol by the liver which was dependent on the magnitude of hepatic uptake of each type of remnant. The recovery of remnant [3H]cholesterol label in the bile was 50% less with palm oil remnants than with all the other remnants studied. The results indicate that the fatty acid composition of chylomicron remnants has a major impact on their uptake and metabolism by the liver. SN - 0264-6021 UR - https://www.unboundmedicine.com/medline/citation/7575417/Variations_in_composition_of_dietary_fats_affect_hepatic_uptake_and_metabolism_of_chylomicron_remnants_ L2 - https://portlandpress.com/biochemj/article-lookup/doi/10.1042/bj3100845 DB - PRIME DP - Unbound Medicine ER -