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Bioavailability of phylloquinone and menaquinones after oral and colorectal administration in vitamin K-deficient rats.
Biochem Pharmacol 1995; 50(6):797-801BP

Abstract

Rats were made vitamin K-deficient by feeding them a diet devoid of vitamin K and by rigorously preventing coprophagy. After one week, circulating prothrombin concentrations were between 5 and 10% of initial values, and various amounts of phylloquinone, menaquinone-4, and menaquinone-9 were given in a single dose either subcutaneously, orally, or colorectally. The relative 'vitamin K activities' of these compounds were assessed by comparing their ability to support prothrombin synthesis after subcutaneous injection. Intestinal and colonic absorption were deduced from the difference between subcutaneous and either oral or colorectal administration of the vitamers. It is concluded that the colonic absorption of all three forms of vitamin K is extremely poor, suggesting that physiological menaquinones in the colon do not contribute substantially to vitamin K status in rats. Furthermore, the stimulation of prothrombin synthesis by menaquinone-9 lasted much longer than that by the two other K-vitamers, resulting in a substantially higher 'vitamin K activity' of menaquinone-9.

Authors+Show Affiliations

Department of Biochemistry, University of Limburg, Maastricht, The Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

7575640

Citation

Groenen-van Dooren, M M., et al. "Bioavailability of Phylloquinone and Menaquinones After Oral and Colorectal Administration in Vitamin K-deficient Rats." Biochemical Pharmacology, vol. 50, no. 6, 1995, pp. 797-801.
Groenen-van Dooren MM, Ronden JE, Soute BA, et al. Bioavailability of phylloquinone and menaquinones after oral and colorectal administration in vitamin K-deficient rats. Biochem Pharmacol. 1995;50(6):797-801.
Groenen-van Dooren, M. M., Ronden, J. E., Soute, B. A., & Vermeer, C. (1995). Bioavailability of phylloquinone and menaquinones after oral and colorectal administration in vitamin K-deficient rats. Biochemical Pharmacology, 50(6), pp. 797-801.
Groenen-van Dooren MM, et al. Bioavailability of Phylloquinone and Menaquinones After Oral and Colorectal Administration in Vitamin K-deficient Rats. Biochem Pharmacol. 1995 Sep 7;50(6):797-801. PubMed PMID: 7575640.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Bioavailability of phylloquinone and menaquinones after oral and colorectal administration in vitamin K-deficient rats. AU - Groenen-van Dooren,M M, AU - Ronden,J E, AU - Soute,B A, AU - Vermeer,C, PY - 1995/9/7/pubmed PY - 1995/9/7/medline PY - 1995/9/7/entrez SP - 797 EP - 801 JF - Biochemical pharmacology JO - Biochem. Pharmacol. VL - 50 IS - 6 N2 - Rats were made vitamin K-deficient by feeding them a diet devoid of vitamin K and by rigorously preventing coprophagy. After one week, circulating prothrombin concentrations were between 5 and 10% of initial values, and various amounts of phylloquinone, menaquinone-4, and menaquinone-9 were given in a single dose either subcutaneously, orally, or colorectally. The relative 'vitamin K activities' of these compounds were assessed by comparing their ability to support prothrombin synthesis after subcutaneous injection. Intestinal and colonic absorption were deduced from the difference between subcutaneous and either oral or colorectal administration of the vitamers. It is concluded that the colonic absorption of all three forms of vitamin K is extremely poor, suggesting that physiological menaquinones in the colon do not contribute substantially to vitamin K status in rats. Furthermore, the stimulation of prothrombin synthesis by menaquinone-9 lasted much longer than that by the two other K-vitamers, resulting in a substantially higher 'vitamin K activity' of menaquinone-9. SN - 0006-2952 UR - https://www.unboundmedicine.com/medline/citation/7575640/Bioavailability_of_phylloquinone_and_menaquinones_after_oral_and_colorectal_administration_in_vitamin_K_deficient_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0006-2952(95)00202-B DB - PRIME DP - Unbound Medicine ER -