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Immunohistochemical demonstration of secretory IgA in human urothelium.
Histol Histopathol. 1995 Jul; 10(3):645-50.HH

Abstract

The mucosal surface of the human urothelium represents a very large exposure area to exogenous agents, including potentially harmful microorganisms. Male human urothelium was treated for the immunohistochemical demonstration of secretory IgA (sIgA) in order to verify its own possible antimicrobial properties. An intense immunoreactivity for sIgA was observed in the apical cells of the urethral and vesical epithelia. The ureteric epithelium, at the luminal surface, showed discontinuous areas of less dense or completely absent reaction product. A less intense immunoreactivity was observed in the pelvic apical epithelial cells. The results suggest that sIgA play a prominent role in the local defence mechanisms of the lower urinary tract against ascending infections, whereas in the upper urinary tract the immuno-specific local defences seem reduced.

Authors+Show Affiliations

Department of Cytomorphology, University of Cagliari, Italy.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

7579813

Citation

Sirigu, P, et al. "Immunohistochemical Demonstration of Secretory IgA in Human Urothelium." Histology and Histopathology, vol. 10, no. 3, 1995, pp. 645-50.
Sirigu P, Perra MT, Turno F, et al. Immunohistochemical demonstration of secretory IgA in human urothelium. Histol Histopathol. 1995;10(3):645-50.
Sirigu, P., Perra, M. T., Turno, F., & Usai, E. (1995). Immunohistochemical demonstration of secretory IgA in human urothelium. Histology and Histopathology, 10(3), 645-50.
Sirigu P, et al. Immunohistochemical Demonstration of Secretory IgA in Human Urothelium. Histol Histopathol. 1995;10(3):645-50. PubMed PMID: 7579813.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Immunohistochemical demonstration of secretory IgA in human urothelium. AU - Sirigu,P, AU - Perra,M T, AU - Turno,F, AU - Usai,E, PY - 1995/7/1/pubmed PY - 1995/7/1/medline PY - 1995/7/1/entrez SP - 645 EP - 50 JF - Histology and histopathology JO - Histol. Histopathol. VL - 10 IS - 3 N2 - The mucosal surface of the human urothelium represents a very large exposure area to exogenous agents, including potentially harmful microorganisms. Male human urothelium was treated for the immunohistochemical demonstration of secretory IgA (sIgA) in order to verify its own possible antimicrobial properties. An intense immunoreactivity for sIgA was observed in the apical cells of the urethral and vesical epithelia. The ureteric epithelium, at the luminal surface, showed discontinuous areas of less dense or completely absent reaction product. A less intense immunoreactivity was observed in the pelvic apical epithelial cells. The results suggest that sIgA play a prominent role in the local defence mechanisms of the lower urinary tract against ascending infections, whereas in the upper urinary tract the immuno-specific local defences seem reduced. SN - 0213-3911 UR - https://www.unboundmedicine.com/medline/citation/7579813/Immunohistochemical_demonstration_of_secretory_IgA_in_human_urothelium_ DB - PRIME DP - Unbound Medicine ER -