Tags

Type your tag names separated by a space and hit enter

Clomiphene citrate and hMG: an alternative stimulation protocol for selected failed in vitro fertilization patients.
J Assist Reprod Genet. 1995 Jan; 12(1):8-12.JA

Abstract

PURPOSE

This study was carried out to evaluate the potential role of the combination clomiphene citrate/human menopausal gonadotropin (CC/hMG) for patients who failed previous in vitro fertilization (IVF) attempts with gonadotropin-releasing hormone analogs (GnRH-a) and/or exogenous gonadotropins.

METHODS

Patients were stimulated with CC/hMG (n = 93) after unsuccessfully undergoing 182 gonadotropin cycles with (n = 106) or without (n = 76) luteal-phase GnRH-a. Cancellation rate, length of stimulation, and peak estradiol levels did not differ significantly between the two regimens.

RESULTS

Although fewer oocytes were retrieved when the CC/hMG combination was used, 16 patients were able to successfully achieve a pregnancy (26.2% delivery rate/transfer). When daily follicle stimulating hormone (FSH) levels were measured in two successive cycles in those women who conceived with the CC/hMG stimulation, baseline levels did not differ when compared with a previous GnRH-a/hMG cycle. Nevertheless, serum FSH levels rose rapidly and remained higher in the GnRH-a/hMG cycle, reaching significantly higher levels on day of human chorionic gonadotropin (hCG) administration.

CONCLUSION

Selected patients who failed previous IVF attempts with gonadotropins with or without GnRH analogs may benefit from the addition of CC to their ovarian stimulation protocol.

Authors+Show Affiliations

New York Hospital-Cornell Medical Center, Department of Obstetrics and Gynecology, New York 10021, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

7580013

Citation

Benadiva, C A., et al. "Clomiphene Citrate and hMG: an Alternative Stimulation Protocol for Selected Failed in Vitro Fertilization Patients." Journal of Assisted Reproduction and Genetics, vol. 12, no. 1, 1995, pp. 8-12.
Benadiva CA, Davis O, Kligman I, et al. Clomiphene citrate and hMG: an alternative stimulation protocol for selected failed in vitro fertilization patients. J Assist Reprod Genet. 1995;12(1):8-12.
Benadiva, C. A., Davis, O., Kligman, I., Liu, H. C., & Rosenwaks, Z. (1995). Clomiphene citrate and hMG: an alternative stimulation protocol for selected failed in vitro fertilization patients. Journal of Assisted Reproduction and Genetics, 12(1), 8-12.
Benadiva CA, et al. Clomiphene Citrate and hMG: an Alternative Stimulation Protocol for Selected Failed in Vitro Fertilization Patients. J Assist Reprod Genet. 1995;12(1):8-12. PubMed PMID: 7580013.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clomiphene citrate and hMG: an alternative stimulation protocol for selected failed in vitro fertilization patients. AU - Benadiva,C A, AU - Davis,O, AU - Kligman,I, AU - Liu,H C, AU - Rosenwaks,Z, PY - 1995/1/1/pubmed PY - 1995/1/1/medline PY - 1995/1/1/entrez SP - 8 EP - 12 JF - Journal of assisted reproduction and genetics JO - J Assist Reprod Genet VL - 12 IS - 1 N2 - PURPOSE: This study was carried out to evaluate the potential role of the combination clomiphene citrate/human menopausal gonadotropin (CC/hMG) for patients who failed previous in vitro fertilization (IVF) attempts with gonadotropin-releasing hormone analogs (GnRH-a) and/or exogenous gonadotropins. METHODS: Patients were stimulated with CC/hMG (n = 93) after unsuccessfully undergoing 182 gonadotropin cycles with (n = 106) or without (n = 76) luteal-phase GnRH-a. Cancellation rate, length of stimulation, and peak estradiol levels did not differ significantly between the two regimens. RESULTS: Although fewer oocytes were retrieved when the CC/hMG combination was used, 16 patients were able to successfully achieve a pregnancy (26.2% delivery rate/transfer). When daily follicle stimulating hormone (FSH) levels were measured in two successive cycles in those women who conceived with the CC/hMG stimulation, baseline levels did not differ when compared with a previous GnRH-a/hMG cycle. Nevertheless, serum FSH levels rose rapidly and remained higher in the GnRH-a/hMG cycle, reaching significantly higher levels on day of human chorionic gonadotropin (hCG) administration. CONCLUSION: Selected patients who failed previous IVF attempts with gonadotropins with or without GnRH analogs may benefit from the addition of CC to their ovarian stimulation protocol. SN - 1058-0468 UR - https://www.unboundmedicine.com/medline/citation/7580013/Clomiphene_citrate_and_hMG:_an_alternative_stimulation_protocol_for_selected_failed_in_vitro_fertilization_patients_ DB - PRIME DP - Unbound Medicine ER -