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Intensive therapy and progression to clinical albuminuria in patients with insulin dependent diabetes mellitus and microalbuminuria. Microalbuminuria Collaborative Study Group, United Kingdom.
BMJ 1995; 311(7011):973-7BMJ

Abstract

OBJECTIVE

To study the effect of intensive therapy of diabetes on the progression to clinical albuminuria in insulin dependent diabetic patients with microalbuminuria.

DESIGN

Randomised controlled clinical trial of intensive versus conventional therapy of diabetes for a median of 5 years (range 2-8).

SETTING

Nine hospital based specialist diabetes centres in England and Wales.

SUBJECTS

70 European insulin dependent diabetic patients aged 17-59 years with microalbuminuria (albumin excretion 30-199 micrograms/min), but without arterial hypertension, recruited from the nine hospital based specialist diabetes centres.

INTERVENTIONS

Intensive diabetic therapy was allocated to 36 patients (27 men, 9 women) and conventional diabetic therapy to 34 (24 men, 10 women).

MAIN OUTCOME MEASURES

Development of clinical albuminuria, defined as albumin excretion greater than 200 micrograms/min on at least two consecutive occasions, and rate of change of albumin excretion.

RESULTS

Mean glycated haemoglobin concentration, similar at baseline in the two groups (intensive therapy group 10.3% (SEM 1.9%), conventional therapy group 9.8% (1.6%)), fell significantly (by 14%) in the intensive therapy group only. A significant glycaemic separation between the two groups was maintained for up to three years. Progression to clinical albuminuria occurred in six patients in each group. Blood pressure, similar at baseline, fell significantly by 1 mm Hg (95% confidence interval -4.20 to 1.43) per year in the conventional therapy group, but the difference in the rate of blood pressure change between the groups was not significant. Independent of treatment assignment, a mean blood pressure above the group mean (93.6 mm Hg), but not the glycated haemoglobin concentration, predicted progression to clinical albuminuria (relative risk 4.2, 95% confidence interval 1.3 to 13.0).

CONCLUSIONS

Intensive therapy with improved glycaemic control for three years had no impact on the progression of albuminuria in insulin dependent diabetic patients with microalbuminuria. The reduction in blood pressure in the conventional therapy group may have affected outcome--in that arterial blood pressure rather than glycated haemoglobin concentration seemed to be the main predictor of progression from microalbuminuria to clinical albuminuria.

Pub Type(s)

Clinical Trial
Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

7580637

Citation

"Intensive Therapy and Progression to Clinical Albuminuria in Patients With Insulin Dependent Diabetes Mellitus and Microalbuminuria. Microalbuminuria Collaborative Study Group, United Kingdom." BMJ (Clinical Research Ed.), vol. 311, no. 7011, 1995, pp. 973-7.
Intensive therapy and progression to clinical albuminuria in patients with insulin dependent diabetes mellitus and microalbuminuria. Microalbuminuria Collaborative Study Group, United Kingdom. BMJ. 1995;311(7011):973-7.
(1995). Intensive therapy and progression to clinical albuminuria in patients with insulin dependent diabetes mellitus and microalbuminuria. Microalbuminuria Collaborative Study Group, United Kingdom. BMJ (Clinical Research Ed.), 311(7011), pp. 973-7.
Intensive Therapy and Progression to Clinical Albuminuria in Patients With Insulin Dependent Diabetes Mellitus and Microalbuminuria. Microalbuminuria Collaborative Study Group, United Kingdom. BMJ. 1995 Oct 14;311(7011):973-7. PubMed PMID: 7580637.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Intensive therapy and progression to clinical albuminuria in patients with insulin dependent diabetes mellitus and microalbuminuria. Microalbuminuria Collaborative Study Group, United Kingdom. PY - 1995/10/14/pubmed PY - 1995/10/14/medline PY - 1995/10/14/entrez SP - 973 EP - 7 JF - BMJ (Clinical research ed.) JO - BMJ VL - 311 IS - 7011 N2 - OBJECTIVE: To study the effect of intensive therapy of diabetes on the progression to clinical albuminuria in insulin dependent diabetic patients with microalbuminuria. DESIGN: Randomised controlled clinical trial of intensive versus conventional therapy of diabetes for a median of 5 years (range 2-8). SETTING: Nine hospital based specialist diabetes centres in England and Wales. SUBJECTS: 70 European insulin dependent diabetic patients aged 17-59 years with microalbuminuria (albumin excretion 30-199 micrograms/min), but without arterial hypertension, recruited from the nine hospital based specialist diabetes centres. INTERVENTIONS: Intensive diabetic therapy was allocated to 36 patients (27 men, 9 women) and conventional diabetic therapy to 34 (24 men, 10 women). MAIN OUTCOME MEASURES: Development of clinical albuminuria, defined as albumin excretion greater than 200 micrograms/min on at least two consecutive occasions, and rate of change of albumin excretion. RESULTS: Mean glycated haemoglobin concentration, similar at baseline in the two groups (intensive therapy group 10.3% (SEM 1.9%), conventional therapy group 9.8% (1.6%)), fell significantly (by 14%) in the intensive therapy group only. A significant glycaemic separation between the two groups was maintained for up to three years. Progression to clinical albuminuria occurred in six patients in each group. Blood pressure, similar at baseline, fell significantly by 1 mm Hg (95% confidence interval -4.20 to 1.43) per year in the conventional therapy group, but the difference in the rate of blood pressure change between the groups was not significant. Independent of treatment assignment, a mean blood pressure above the group mean (93.6 mm Hg), but not the glycated haemoglobin concentration, predicted progression to clinical albuminuria (relative risk 4.2, 95% confidence interval 1.3 to 13.0). CONCLUSIONS: Intensive therapy with improved glycaemic control for three years had no impact on the progression of albuminuria in insulin dependent diabetic patients with microalbuminuria. The reduction in blood pressure in the conventional therapy group may have affected outcome--in that arterial blood pressure rather than glycated haemoglobin concentration seemed to be the main predictor of progression from microalbuminuria to clinical albuminuria. SN - 0959-8138 UR - https://www.unboundmedicine.com/medline/citation/7580637/Intensive_therapy_and_progression_to_clinical_albuminuria_in_patients_with_insulin_dependent_diabetes_mellitus_and_microalbuminuria__Microalbuminuria_Collaborative_Study_Group_United_Kingdom_ L2 - http://www.bmj.com/cgi/pmidlookup?view=long&pmid=7580637 DB - PRIME DP - Unbound Medicine ER -