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Rhinovirus inhalation causes long-lasting excessive airway narrowing in response to methacholine in asthmatic subjects in vivo.
Am J Respir Crit Care Med 1995; 152(5 Pt 1):1490-6AJ

Abstract

Exacerbations of asthma are often associated with respiratory infections, and particularly those caused by rhinovirus. The causative role of rhinovirus in these acute episodes is still unclear, since it has not been determined whether or not infection with the virus promotes excessive airway narrowing in asthma. We tested the hypothesis that experimental infection with inhaled wild-type rhinovirus 16 (RV16) increases the maximal degree of airway narrowing in response to bronchoconstrictor stimuli in patients with mild to moderate asthma. Fourteen nonsmoking subjects with atopic asthma and normal FEV1 values participated in a double-blind, placebo-controlled, parallel study. A total dose of 3 x 10(4) of the 50% tissue-culture-infective dose (TCID50) of RV16 or a placebo was administered by pipette, atomizer, and nebulizer in equal doses into both nostrils on two consecutive days. Dose-response curves for inhaled methacholine were recorded 1 d before and 2, 7, and 15 d after RV16 infection or placebo. The response to methacholine was measured by the percent decrease in FEV1, and the maximal degree of airway narrowing was expressed by the average response on the plateau of the dose-response curve. In the seven subjects receiving the virus, RV16 infection was confirmed in nasal washings and/or by an increase in antibody titer, whereas these tests were negative in the placebo group. There was no significant change in baseline FEV1 during the study in either group (p = 0.06).(

ABSTRACT

TRUNCATED AT 250 WORDS)

Authors+Show Affiliations

Department of Pulmonology, University Hosptial Leiden, The Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Controlled Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

7582282

Citation

Cheung, D, et al. "Rhinovirus Inhalation Causes Long-lasting Excessive Airway Narrowing in Response to Methacholine in Asthmatic Subjects in Vivo." American Journal of Respiratory and Critical Care Medicine, vol. 152, no. 5 Pt 1, 1995, pp. 1490-6.
Cheung D, Dick EC, Timmers MC, et al. Rhinovirus inhalation causes long-lasting excessive airway narrowing in response to methacholine in asthmatic subjects in vivo. Am J Respir Crit Care Med. 1995;152(5 Pt 1):1490-6.
Cheung, D., Dick, E. C., Timmers, M. C., de Klerk, E. P., Spaan, W. J., & Sterk, P. J. (1995). Rhinovirus inhalation causes long-lasting excessive airway narrowing in response to methacholine in asthmatic subjects in vivo. American Journal of Respiratory and Critical Care Medicine, 152(5 Pt 1), pp. 1490-6.
Cheung D, et al. Rhinovirus Inhalation Causes Long-lasting Excessive Airway Narrowing in Response to Methacholine in Asthmatic Subjects in Vivo. Am J Respir Crit Care Med. 1995;152(5 Pt 1):1490-6. PubMed PMID: 7582282.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Rhinovirus inhalation causes long-lasting excessive airway narrowing in response to methacholine in asthmatic subjects in vivo. AU - Cheung,D, AU - Dick,E C, AU - Timmers,M C, AU - de Klerk,E P, AU - Spaan,W J, AU - Sterk,P J, PY - 1995/11/1/pubmed PY - 1995/11/1/medline PY - 1995/11/1/entrez SP - 1490 EP - 6 JF - American journal of respiratory and critical care medicine JO - Am. J. Respir. Crit. Care Med. VL - 152 IS - 5 Pt 1 N2 - Exacerbations of asthma are often associated with respiratory infections, and particularly those caused by rhinovirus. The causative role of rhinovirus in these acute episodes is still unclear, since it has not been determined whether or not infection with the virus promotes excessive airway narrowing in asthma. We tested the hypothesis that experimental infection with inhaled wild-type rhinovirus 16 (RV16) increases the maximal degree of airway narrowing in response to bronchoconstrictor stimuli in patients with mild to moderate asthma. Fourteen nonsmoking subjects with atopic asthma and normal FEV1 values participated in a double-blind, placebo-controlled, parallel study. A total dose of 3 x 10(4) of the 50% tissue-culture-infective dose (TCID50) of RV16 or a placebo was administered by pipette, atomizer, and nebulizer in equal doses into both nostrils on two consecutive days. Dose-response curves for inhaled methacholine were recorded 1 d before and 2, 7, and 15 d after RV16 infection or placebo. The response to methacholine was measured by the percent decrease in FEV1, and the maximal degree of airway narrowing was expressed by the average response on the plateau of the dose-response curve. In the seven subjects receiving the virus, RV16 infection was confirmed in nasal washings and/or by an increase in antibody titer, whereas these tests were negative in the placebo group. There was no significant change in baseline FEV1 during the study in either group (p = 0.06).(ABSTRACT TRUNCATED AT 250 WORDS) SN - 1073-449X UR - https://www.unboundmedicine.com/medline/citation/7582282/Rhinovirus_inhalation_causes_long_lasting_excessive_airway_narrowing_in_response_to_methacholine_in_asthmatic_subjects_in_vivo_ L2 - http://www.atsjournals.org/doi/full/10.1164/ajrccm.152.5.7582282?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -