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High dose inhibition of the tryptophan peptide induced encephalitogenicity.
Immunol Commun. 1978; 7(1):57-67.IC

Abstract

In a previous publication (Immunol. Comm. 3:219, 1974) a hypothesis was proposed that the high dose inhibition of encephalitogenicity in giunea pigs seen with the tryptophan peptide, phe ser trp gly ala glu gly gln arg, and not observed with the whole myelin basic protein which contains this sequence, was the result of competitive inhibition by non-encephalitogenic fragments of the tryptophan peptide produced in vivo possibly by exopeptidases. I present data which disagrees with this hypothesis.

Authors

No affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

75835

Citation

Westall, F C.. "High Dose Inhibition of the Tryptophan Peptide Induced Encephalitogenicity." Immunological Communications, vol. 7, no. 1, 1978, pp. 57-67.
Westall FC. High dose inhibition of the tryptophan peptide induced encephalitogenicity. Immunol Commun. 1978;7(1):57-67.
Westall, F. C. (1978). High dose inhibition of the tryptophan peptide induced encephalitogenicity. Immunological Communications, 7(1), 57-67.
Westall FC. High Dose Inhibition of the Tryptophan Peptide Induced Encephalitogenicity. Immunol Commun. 1978;7(1):57-67. PubMed PMID: 75835.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - High dose inhibition of the tryptophan peptide induced encephalitogenicity. A1 - Westall,F C, PY - 1978/1/1/pubmed PY - 1978/1/1/medline PY - 1978/1/1/entrez SP - 57 EP - 67 JF - Immunological communications JO - Immunol Commun VL - 7 IS - 1 N2 - In a previous publication (Immunol. Comm. 3:219, 1974) a hypothesis was proposed that the high dose inhibition of encephalitogenicity in giunea pigs seen with the tryptophan peptide, phe ser trp gly ala glu gly gln arg, and not observed with the whole myelin basic protein which contains this sequence, was the result of competitive inhibition by non-encephalitogenic fragments of the tryptophan peptide produced in vivo possibly by exopeptidases. I present data which disagrees with this hypothesis. SN - 0090-0877 UR - https://www.unboundmedicine.com/medline/citation/75835/High_dose_inhibition_of_the_tryptophan_peptide_induced_encephalitogenicity_ DB - PRIME DP - Unbound Medicine ER -