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The place for curative surgical procedures in the treatment of sporadic and familial Zollinger-Ellison syndrome.

Abstract

The surgical treatment of patients with the Zollinger-Ellison syndrome has undergone a dramatic evolution since the syndrome was originally described. It is now recognized that an aggressive surgical approach is mandatory because of the malignant potential of gastrinomas in both the sporadic and the familial forms of the syndrome. Although initially regarded as an incurable neoplasm, it is now known that complete surgical resection of gastrinomas can result in eugastrinemia even in the presence of lymph node metastases. It is now recognized that extrapancreatic gastrinomas are more common than pancreatic gastrinomas, and the most common location for an extrapancreatic gastrinoma is the duodenal wall. Major improvements in preoperative imaging and intraoperative localization techniques combined with an increased awareness of the anatomic distribution of gastrinomas have markedly increased the surgeon's ability to care for and cure patients with the Zollinger-Ellison syndrome.

Authors+Show Affiliations

Department of Surgery, University of Kansas Medical Center, Kansas City 66160-7309, USA.No affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

7584013

Citation

Delcore, R, and S R. Friesen. "The Place for Curative Surgical Procedures in the Treatment of Sporadic and Familial Zollinger-Ellison Syndrome." Current Opinion in General Surgery, 1994, pp. 69-76.
Delcore R, Friesen SR. The place for curative surgical procedures in the treatment of sporadic and familial Zollinger-Ellison syndrome. Curr Opin Gen Surg. 1994.
Delcore, R., & Friesen, S. R. (1994). The place for curative surgical procedures in the treatment of sporadic and familial Zollinger-Ellison syndrome. Current Opinion in General Surgery, 69-76.
Delcore R, Friesen SR. The Place for Curative Surgical Procedures in the Treatment of Sporadic and Familial Zollinger-Ellison Syndrome. Curr Opin Gen Surg. 1994;69-76. PubMed PMID: 7584013.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The place for curative surgical procedures in the treatment of sporadic and familial Zollinger-Ellison syndrome. AU - Delcore,R, AU - Friesen,S R, PY - 1994/1/1/pubmed PY - 1994/1/1/medline PY - 1994/1/1/entrez SP - 69 EP - 76 JF - Current opinion in general surgery JO - Curr Opin Gen Surg N2 - The surgical treatment of patients with the Zollinger-Ellison syndrome has undergone a dramatic evolution since the syndrome was originally described. It is now recognized that an aggressive surgical approach is mandatory because of the malignant potential of gastrinomas in both the sporadic and the familial forms of the syndrome. Although initially regarded as an incurable neoplasm, it is now known that complete surgical resection of gastrinomas can result in eugastrinemia even in the presence of lymph node metastases. It is now recognized that extrapancreatic gastrinomas are more common than pancreatic gastrinomas, and the most common location for an extrapancreatic gastrinoma is the duodenal wall. Major improvements in preoperative imaging and intraoperative localization techniques combined with an increased awareness of the anatomic distribution of gastrinomas have markedly increased the surgeon's ability to care for and cure patients with the Zollinger-Ellison syndrome. SN - 1065-6243 UR - https://www.unboundmedicine.com/medline/citation/7584013/The_place_for_curative_surgical_procedures_in_the_treatment_of_sporadic_and_familial_Zollinger_Ellison_syndrome_ L2 - http://www.diseaseinfosearch.org/result/7600 DB - PRIME DP - Unbound Medicine ER -