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Apolipoprotein E epsilon 4 allele is associated with deposition of amyloid beta-protein following head injury.
Nat Med 1995; 1(2):135-7NMed

Abstract

Deposition of amyloid beta-protein (A beta) in the brain plays a key role in the pathogenesis of Alzheimer's disease. Apolipoprotein E epsilon 4 allele (apo E-epsilon 4) is a strong risk factor for Alzheimer's disease, and there is in vitro evidence that apo E is directly involved in A beta deposition. Head injury is an epidemiological risk factor for Alzheimer's disease and deposition of A beta occurs in approximately one-third of individuals dying after a severe head injury. We report here that the frequency of apo E-epsilon 4 in those individuals with A beta deposition following head injury (0.52) is higher than in most studies of Alzheimer's disease, while in those head-injured individuals without A beta deposition the apo E-epsilon 4 frequency (0.16) is similar to controls without Alzheimer's disease (P < 0.00001). This finding provides further evidence linking apo E-epsilon 4 with A beta deposition in vivo and suggests that known environmental and genetic risk factors for Alzheimer's disease may act additively. In addition our finding indicates a genetic susceptibility to the effects of a head injury.

Authors+Show Affiliations

Department of Neuropathology, Southern General Hospital, Glasgow, UK.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

7585009

Citation

Nicoll, J A., et al. "Apolipoprotein E Epsilon 4 Allele Is Associated With Deposition of Amyloid Beta-protein Following Head Injury." Nature Medicine, vol. 1, no. 2, 1995, pp. 135-7.
Nicoll JA, Roberts GW, Graham DI. Apolipoprotein E epsilon 4 allele is associated with deposition of amyloid beta-protein following head injury. Nat Med. 1995;1(2):135-7.
Nicoll, J. A., Roberts, G. W., & Graham, D. I. (1995). Apolipoprotein E epsilon 4 allele is associated with deposition of amyloid beta-protein following head injury. Nature Medicine, 1(2), pp. 135-7.
Nicoll JA, Roberts GW, Graham DI. Apolipoprotein E Epsilon 4 Allele Is Associated With Deposition of Amyloid Beta-protein Following Head Injury. Nat Med. 1995;1(2):135-7. PubMed PMID: 7585009.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Apolipoprotein E epsilon 4 allele is associated with deposition of amyloid beta-protein following head injury. AU - Nicoll,J A, AU - Roberts,G W, AU - Graham,D I, PY - 1995/2/1/pubmed PY - 1995/2/1/medline PY - 1995/2/1/entrez SP - 135 EP - 7 JF - Nature medicine JO - Nat. Med. VL - 1 IS - 2 N2 - Deposition of amyloid beta-protein (A beta) in the brain plays a key role in the pathogenesis of Alzheimer's disease. Apolipoprotein E epsilon 4 allele (apo E-epsilon 4) is a strong risk factor for Alzheimer's disease, and there is in vitro evidence that apo E is directly involved in A beta deposition. Head injury is an epidemiological risk factor for Alzheimer's disease and deposition of A beta occurs in approximately one-third of individuals dying after a severe head injury. We report here that the frequency of apo E-epsilon 4 in those individuals with A beta deposition following head injury (0.52) is higher than in most studies of Alzheimer's disease, while in those head-injured individuals without A beta deposition the apo E-epsilon 4 frequency (0.16) is similar to controls without Alzheimer's disease (P < 0.00001). This finding provides further evidence linking apo E-epsilon 4 with A beta deposition in vivo and suggests that known environmental and genetic risk factors for Alzheimer's disease may act additively. In addition our finding indicates a genetic susceptibility to the effects of a head injury. SN - 1078-8956 UR - https://www.unboundmedicine.com/medline/citation/7585009/Apolipoprotein_E_epsilon_4_allele_is_associated_with_deposition_of_amyloid_beta_protein_following_head_injury_ L2 - http://dx.doi.org/10.1038/nm0295-135 DB - PRIME DP - Unbound Medicine ER -