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Oleanene-type triterpene glycosides from Puerariae Radix. II. Isolation of saponins and the application of tandem mass spectrometry to their structure determination.
Chem Pharm Bull (Tokyo). 1995 Jul; 43(7):1176-9.CP

Abstract

A continuing study of the ingredients of Puerariae Radix, the roots of Pueraria lobata (WILLD.) OHWI, which is one of the most important crude drugs, has resulted in the first isolation of four new oleanene-type triterpene glycosides, named kudzusaponins SA1, SA2, SA3 and C1 (1-4). Their structures were determined to be 3-O-beta-D-galactopyranosyl-(1-->2)-beta-D-glucuronopyranosyl soyasapogenol A (1), 3-O-beta-galactopyranosyl-(1-->2)-beta-D-glucuronopyranosyl soyasapogenol A 22-O-alpha-L-arabinopyranoside (2), 3-O-alpha-L-rhamnopyranosyl-(1-->2)-beta-D-galactopyranosyl-(1-->2)-D- glucuronopyranosyl kudzusapogenol C 21-O-beta-D-glucopyranoside (4), respectively. The usefulness of tandem mass spectrometry in the structural determination of oleanene-type triterpene bisdesmosides is also discussed.

Authors+Show Affiliations

Arao T
Faculty of Pharmaceutical Sciences, Kumamoto University, Japan.
Kinjo J
No affiliation info available
Nohara T
No affiliation info available
Isobe R
No affiliation info available

MeSH

Carbohydrate ConformationCarbohydrate SequenceCarbon IsotopesDrugs, Chinese HerbalGlycosidesMagnetic Resonance SpectroscopyMass SpectrometryMolecular Sequence DataOleanolic AcidPlant RootsPlants, MedicinalSaponinsSpectrometry, Mass, Fast Atom BombardmentTriterpenes

Pub Type(s)

Journal Article

Language

eng

PubMed ID

7586062

Citation

Arao, T, et al. "Oleanene-type Triterpene Glycosides From Puerariae Radix. II. Isolation of Saponins and the Application of Tandem Mass Spectrometry to Their Structure Determination." Chemical & Pharmaceutical Bulletin, vol. 43, no. 7, 1995, pp. 1176-9.
Arao T, Kinjo J, Nohara T, et al. Oleanene-type triterpene glycosides from Puerariae Radix. II. Isolation of saponins and the application of tandem mass spectrometry to their structure determination. Chem Pharm Bull (Tokyo). 1995;43(7):1176-9.
Arao, T., Kinjo, J., Nohara, T., & Isobe, R. (1995). Oleanene-type triterpene glycosides from Puerariae Radix. II. Isolation of saponins and the application of tandem mass spectrometry to their structure determination. Chemical & Pharmaceutical Bulletin, 43(7), 1176-9.
Arao T, et al. Oleanene-type Triterpene Glycosides From Puerariae Radix. II. Isolation of Saponins and the Application of Tandem Mass Spectrometry to Their Structure Determination. Chem Pharm Bull (Tokyo). 1995;43(7):1176-9. PubMed PMID: 7586062.
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TY - JOUR T1 - Oleanene-type triterpene glycosides from Puerariae Radix. II. Isolation of saponins and the application of tandem mass spectrometry to their structure determination. AU - Arao,T, AU - Kinjo,J, AU - Nohara,T, AU - Isobe,R, PY - 1995/7/1/pubmed PY - 1995/7/1/medline PY - 1995/7/1/entrez SP - 1176 EP - 9 JF - Chemical & pharmaceutical bulletin JO - Chem Pharm Bull (Tokyo) VL - 43 IS - 7 N2 - A continuing study of the ingredients of Puerariae Radix, the roots of Pueraria lobata (WILLD.) OHWI, which is one of the most important crude drugs, has resulted in the first isolation of four new oleanene-type triterpene glycosides, named kudzusaponins SA1, SA2, SA3 and C1 (1-4). Their structures were determined to be 3-O-beta-D-galactopyranosyl-(1-->2)-beta-D-glucuronopyranosyl soyasapogenol A (1), 3-O-beta-galactopyranosyl-(1-->2)-beta-D-glucuronopyranosyl soyasapogenol A 22-O-alpha-L-arabinopyranoside (2), 3-O-alpha-L-rhamnopyranosyl-(1-->2)-beta-D-galactopyranosyl-(1-->2)-D- glucuronopyranosyl kudzusapogenol C 21-O-beta-D-glucopyranoside (4), respectively. The usefulness of tandem mass spectrometry in the structural determination of oleanene-type triterpene bisdesmosides is also discussed. SN - 0009-2363 UR - https://www.unboundmedicine.com/medline/citation/7586062/Oleanene_type_triterpene_glycosides_from_Puerariae_Radix__II__Isolation_of_saponins_and_the_application_of_tandem_mass_spectrometry_to_their_structure_determination_ DB - PRIME DP - Unbound Medicine ER -