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High prevalence of diabetic retinopathy and nephropathy in Polynesians of Western Samoa.
Diabetes Care 1995; 18(8):1140-9DC

Abstract

OBJECTIVE

To determine the prevalence of diabetic retinopathy and nephropathy retinopathy and nephropathy and to define associated risk factors in Polynesian Western Samoans with non-insulin-dependent diabetes mellitus (NIDDM) or impaired glucose tolerance (IGT).

RESEARCH DESIGN AND METHODS

A 1991 population-based study in Samoan adults (ages 25-74 years) included a 75-g oral glucose tolerance test, anthropometric measurements, and blood pressure recordings. Subjects with NIDDM or IGT had 45-degree stereo photographs taken (n = 263) (three standard fields of the right eye), and retinopathy was graded in comparison with Airlie House photographs. First-morning urine samples (n = 304) were also collected from these subjects and from a subsample with normal glucose tolerance. Urinary albumin concentration (UAC) was measured by radioimmunoassay: microalbuminuria was defined as UAC of 30-299 micrograms/ml; and macroalbuminuria among subjects with Proliferative diabetic retinopathy was found in 4.5% of known diabetic subjects. The prevalence of elevated UAC was 15.0% in subjects with IGT, 26.0% in newly diagnosed diabetes subjects, and 23.4% in known diabetes subjects. For all diabetic subjects (n = 162), the factors independently associated with diabetic retinopathy (logistic regression) were duration of diabetes, fasting plasma glucose, and body mass index (inversely). Duration of diabetes, serum triglyceride concentrations, and systolic blood pressure were independently associated with elevated UAC in all diabetic subjects (n = 138), and fasting plasma glucose had borderline significance.

CONCLUSIONS

Diabetic retinopathy and albuminuria are common in Polynesian Western Samoans. Duration of diabetes and level of glycemia were the most important associated factors. These data underline the need for cost-effective programs for the detection and early treatment of diabetes in Western Samoa and other developing populations with high susceptibility to NIDDM.

Authors+Show Affiliations

International Diabetes Institute, Melbourne, Australia.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

7587849

Citation

Collins, V R., et al. "High Prevalence of Diabetic Retinopathy and Nephropathy in Polynesians of Western Samoa." Diabetes Care, vol. 18, no. 8, 1995, pp. 1140-9.
Collins VR, Dowse GK, Plehwe WE, et al. High prevalence of diabetic retinopathy and nephropathy in Polynesians of Western Samoa. Diabetes Care. 1995;18(8):1140-9.
Collins, V. R., Dowse, G. K., Plehwe, W. E., Imo, T. T., Toelupe, P. M., Taylor, H. R., & Zimmet, P. Z. (1995). High prevalence of diabetic retinopathy and nephropathy in Polynesians of Western Samoa. Diabetes Care, 18(8), pp. 1140-9.
Collins VR, et al. High Prevalence of Diabetic Retinopathy and Nephropathy in Polynesians of Western Samoa. Diabetes Care. 1995;18(8):1140-9. PubMed PMID: 7587849.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - High prevalence of diabetic retinopathy and nephropathy in Polynesians of Western Samoa. AU - Collins,V R, AU - Dowse,G K, AU - Plehwe,W E, AU - Imo,T T, AU - Toelupe,P M, AU - Taylor,H R, AU - Zimmet,P Z, PY - 1995/8/1/pubmed PY - 1995/8/1/medline PY - 1995/8/1/entrez SP - 1140 EP - 9 JF - Diabetes care JO - Diabetes Care VL - 18 IS - 8 N2 - OBJECTIVE: To determine the prevalence of diabetic retinopathy and nephropathy retinopathy and nephropathy and to define associated risk factors in Polynesian Western Samoans with non-insulin-dependent diabetes mellitus (NIDDM) or impaired glucose tolerance (IGT). RESEARCH DESIGN AND METHODS: A 1991 population-based study in Samoan adults (ages 25-74 years) included a 75-g oral glucose tolerance test, anthropometric measurements, and blood pressure recordings. Subjects with NIDDM or IGT had 45-degree stereo photographs taken (n = 263) (three standard fields of the right eye), and retinopathy was graded in comparison with Airlie House photographs. First-morning urine samples (n = 304) were also collected from these subjects and from a subsample with normal glucose tolerance. Urinary albumin concentration (UAC) was measured by radioimmunoassay: microalbuminuria was defined as UAC of 30-299 micrograms/ml; and macroalbuminuria among subjects with Proliferative diabetic retinopathy was found in 4.5% of known diabetic subjects. The prevalence of elevated UAC was 15.0% in subjects with IGT, 26.0% in newly diagnosed diabetes subjects, and 23.4% in known diabetes subjects. For all diabetic subjects (n = 162), the factors independently associated with diabetic retinopathy (logistic regression) were duration of diabetes, fasting plasma glucose, and body mass index (inversely). Duration of diabetes, serum triglyceride concentrations, and systolic blood pressure were independently associated with elevated UAC in all diabetic subjects (n = 138), and fasting plasma glucose had borderline significance. CONCLUSIONS: Diabetic retinopathy and albuminuria are common in Polynesian Western Samoans. Duration of diabetes and level of glycemia were the most important associated factors. These data underline the need for cost-effective programs for the detection and early treatment of diabetes in Western Samoa and other developing populations with high susceptibility to NIDDM. SN - 0149-5992 UR - https://www.unboundmedicine.com/medline/citation/7587849/High_prevalence_of_diabetic_retinopathy_and_nephropathy_in_Polynesians_of_Western_Samoa_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=7587849.ui DB - PRIME DP - Unbound Medicine ER -