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Serum lipids and lipoprotein(a) concentrations in Chinese NIDDM patients. Relation to metabolic control.
Diabetes Care 1995; 18(8):1191-4DC

Abstract

OBJECTIVE

To compare serum blood lipids and lipoprotein(a) [Lp(a)] levels in Chinese non-insulin-dependent diabetes mellitus (NIDDM) patients and nondiabetic control subjects and also to determine the influence of diabetes control on serum Lp(a) concentration in Chinese individuals.

RESEARCH DESIGN AND METHODS

We compared the serum blood lipids and Lp(a) levels in NIDDM patients (n = 100) and age- and sex-matched nondiabetic subjects (n = 100) who participated in a case-control study. Comparisons of Lp(a) concentrations were made between a normal control group, a group of diabetic patients with HbA1c < 8.0%, and a group of diabetic patients with HbA1c of 8% or higher.

RESULTS

The diabetic patients had higher total triglyceride, apolipoprotein B (apo B), and apo B-to-apo AI ratios, but lower high-density lipoprotein (HDL) cholesterol and apo AI concentrations than nondiabetic controls (P < 0.001, P < 0.01, P < 0.001, P < 0.05, and P < 0.001, respectively). A similar pattern of distribution of Lp(a) levels according to the degree of metabolic control was seen in patients with NIDDM and nondiabetic controls. No correlation was observed between Lp(a) levels and total cholesterol, low-density lipoprotein cholesterol, HDL cholesterol, apo AI, apo B, and triglyceride levels in all diabetic patients. No difference in the Lp(a) levels was noted between diabetic patients and nondiabetic subjects, even in poorly controlled diabetic patients.

CONCLUSIONS

In conclusion, Lp(a) levels are not elevated in diabetic patients, even in poorly controlled metabolic conditions.

Authors+Show Affiliations

Department of Family Medicine, Medical College, National Taiwan University.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

7587858

Citation

Chang, C J., et al. "Serum Lipids and Lipoprotein(a) Concentrations in Chinese NIDDM Patients. Relation to Metabolic Control." Diabetes Care, vol. 18, no. 8, 1995, pp. 1191-4.
Chang CJ, Kao JT, Wu TJ, et al. Serum lipids and lipoprotein(a) concentrations in Chinese NIDDM patients. Relation to metabolic control. Diabetes Care. 1995;18(8):1191-4.
Chang, C. J., Kao, J. T., Wu, T. J., Lu, F. H., & Tai, T. Y. (1995). Serum lipids and lipoprotein(a) concentrations in Chinese NIDDM patients. Relation to metabolic control. Diabetes Care, 18(8), pp. 1191-4.
Chang CJ, et al. Serum Lipids and Lipoprotein(a) Concentrations in Chinese NIDDM Patients. Relation to Metabolic Control. Diabetes Care. 1995;18(8):1191-4. PubMed PMID: 7587858.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serum lipids and lipoprotein(a) concentrations in Chinese NIDDM patients. Relation to metabolic control. AU - Chang,C J, AU - Kao,J T, AU - Wu,T J, AU - Lu,F H, AU - Tai,T Y, PY - 1995/8/1/pubmed PY - 1995/8/1/medline PY - 1995/8/1/entrez SP - 1191 EP - 4 JF - Diabetes care JO - Diabetes Care VL - 18 IS - 8 N2 - OBJECTIVE: To compare serum blood lipids and lipoprotein(a) [Lp(a)] levels in Chinese non-insulin-dependent diabetes mellitus (NIDDM) patients and nondiabetic control subjects and also to determine the influence of diabetes control on serum Lp(a) concentration in Chinese individuals. RESEARCH DESIGN AND METHODS: We compared the serum blood lipids and Lp(a) levels in NIDDM patients (n = 100) and age- and sex-matched nondiabetic subjects (n = 100) who participated in a case-control study. Comparisons of Lp(a) concentrations were made between a normal control group, a group of diabetic patients with HbA1c < 8.0%, and a group of diabetic patients with HbA1c of 8% or higher. RESULTS: The diabetic patients had higher total triglyceride, apolipoprotein B (apo B), and apo B-to-apo AI ratios, but lower high-density lipoprotein (HDL) cholesterol and apo AI concentrations than nondiabetic controls (P < 0.001, P < 0.01, P < 0.001, P < 0.05, and P < 0.001, respectively). A similar pattern of distribution of Lp(a) levels according to the degree of metabolic control was seen in patients with NIDDM and nondiabetic controls. No correlation was observed between Lp(a) levels and total cholesterol, low-density lipoprotein cholesterol, HDL cholesterol, apo AI, apo B, and triglyceride levels in all diabetic patients. No difference in the Lp(a) levels was noted between diabetic patients and nondiabetic subjects, even in poorly controlled diabetic patients. CONCLUSIONS: In conclusion, Lp(a) levels are not elevated in diabetic patients, even in poorly controlled metabolic conditions. SN - 0149-5992 UR - https://www.unboundmedicine.com/medline/citation/7587858/Serum_lipids_and_lipoprotein_a__concentrations_in_Chinese_NIDDM_patients__Relation_to_metabolic_control_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&amp;PAGE=linkout&amp;SEARCH=7587858.ui DB - PRIME DP - Unbound Medicine ER -