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The effect of intraoperative mebendazole-albendazole applications on the hepatobiliary system.
Eur Surg Res 1995; 27(5):340-5ES

Abstract

Caustic sclerosing cholangitis occurs with the use of scolicidal solutions in liver hydatid disease draining into the biliary system. In this study, we investigated the effectiveness of benzimidazole solutions, their in vitro scolicidal effects and the histopathological changes in the hepatobiliary system due to their intraoperative use. It was found that 5 mg% mebendazole and 1 mg% albendazole have strong scolicidal effects. In an in vivo study, under general anesthesia, 5% mebendazole in group I, 1% albendazole in group II and normal saline in group III were injected into the biliary system of rabbits. Liver biochemical tests showed no significant changes. More elaborate ductal mucosal proliferation, ductal dilatation and periductal fibrosis were found in group I compared with group II in biopsies taken on the 60th day. The biopsies of group III were normal.

Authors+Show Affiliations

Department of General Surgery, OMU School of Medicine, Samsun, Turkey.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

7589006

Citation

Erzurumlu, K, et al. "The Effect of Intraoperative Mebendazole-albendazole Applications On the Hepatobiliary System." European Surgical Research. Europaische Chirurgische Forschung. Recherches Chirurgicales Europeennes, vol. 27, no. 5, 1995, pp. 340-5.
Erzurumlu K, Ozdemir M, Mihmanli M, et al. The effect of intraoperative mebendazole-albendazole applications on the hepatobiliary system. Eur Surg Res. 1995;27(5):340-5.
Erzurumlu, K., Ozdemir, M., Mihmanli, M., & Cevikbaş, U. (1995). The effect of intraoperative mebendazole-albendazole applications on the hepatobiliary system. European Surgical Research. Europaische Chirurgische Forschung. Recherches Chirurgicales Europeennes, 27(5), pp. 340-5.
Erzurumlu K, et al. The Effect of Intraoperative Mebendazole-albendazole Applications On the Hepatobiliary System. Eur Surg Res. 1995;27(5):340-5. PubMed PMID: 7589006.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effect of intraoperative mebendazole-albendazole applications on the hepatobiliary system. AU - Erzurumlu,K, AU - Ozdemir,M, AU - Mihmanli,M, AU - Cevikbaş,U, PY - 1995/1/1/pubmed PY - 1995/1/1/medline PY - 1995/1/1/entrez SP - 340 EP - 5 JF - European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes JO - Eur Surg Res VL - 27 IS - 5 N2 - Caustic sclerosing cholangitis occurs with the use of scolicidal solutions in liver hydatid disease draining into the biliary system. In this study, we investigated the effectiveness of benzimidazole solutions, their in vitro scolicidal effects and the histopathological changes in the hepatobiliary system due to their intraoperative use. It was found that 5 mg% mebendazole and 1 mg% albendazole have strong scolicidal effects. In an in vivo study, under general anesthesia, 5% mebendazole in group I, 1% albendazole in group II and normal saline in group III were injected into the biliary system of rabbits. Liver biochemical tests showed no significant changes. More elaborate ductal mucosal proliferation, ductal dilatation and periductal fibrosis were found in group I compared with group II in biopsies taken on the 60th day. The biopsies of group III were normal. SN - 0014-312X UR - https://www.unboundmedicine.com/medline/citation/7589006/The_effect_of_intraoperative_mebendazole_albendazole_applications_on_the_hepatobiliary_system_ L2 - https://www.karger.com?DOI=10.1159/000129418 DB - PRIME DP - Unbound Medicine ER -