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The effect of intraoperative mebendazole-albendazole applications on the hepatobiliary system.

Abstract

Caustic sclerosing cholangitis occurs with the use of scolicidal solutions in liver hydatid disease draining into the biliary system. In this study, we investigated the effectiveness of benzimidazole solutions, their in vitro scolicidal effects and the histopathological changes in the hepatobiliary system due to their intraoperative use. It was found that 5 mg% mebendazole and 1 mg% albendazole have strong scolicidal effects. In an in vivo study, under general anesthesia, 5% mebendazole in group I, 1% albendazole in group II and normal saline in group III were injected into the biliary system of rabbits. Liver biochemical tests showed no significant changes. More elaborate ductal mucosal proliferation, ductal dilatation and periductal fibrosis were found in group I compared with group II in biopsies taken on the 60th day. The biopsies of group III were normal.

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  • Authors+Show Affiliations

    ,

    Department of General Surgery, OMU School of Medicine, Samsun, Turkey.

    , ,

    Source

    MeSH

    Albendazole
    Animals
    Anthelmintics
    Antinematodal Agents
    Bile Ducts
    Echinococcosis, Hepatic
    Humans
    Intraoperative Care
    Liver
    Mebendazole
    Rabbits

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    7589006

    Citation

    Erzurumlu, K, et al. "The Effect of Intraoperative Mebendazole-albendazole Applications On the Hepatobiliary System." European Surgical Research. Europaische Chirurgische Forschung. Recherches Chirurgicales Europeennes, vol. 27, no. 5, 1995, pp. 340-5.
    Erzurumlu K, Ozdemir M, Mihmanli M, et al. The effect of intraoperative mebendazole-albendazole applications on the hepatobiliary system. Eur Surg Res. 1995;27(5):340-5.
    Erzurumlu, K., Ozdemir, M., Mihmanli, M., & Cevikbaş, U. (1995). The effect of intraoperative mebendazole-albendazole applications on the hepatobiliary system. European Surgical Research. Europaische Chirurgische Forschung. Recherches Chirurgicales Europeennes, 27(5), pp. 340-5.
    Erzurumlu K, et al. The Effect of Intraoperative Mebendazole-albendazole Applications On the Hepatobiliary System. Eur Surg Res. 1995;27(5):340-5. PubMed PMID: 7589006.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - The effect of intraoperative mebendazole-albendazole applications on the hepatobiliary system. AU - Erzurumlu,K, AU - Ozdemir,M, AU - Mihmanli,M, AU - Cevikbaş,U, PY - 1995/1/1/pubmed PY - 1995/1/1/medline PY - 1995/1/1/entrez SP - 340 EP - 5 JF - European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes JO - Eur Surg Res VL - 27 IS - 5 N2 - Caustic sclerosing cholangitis occurs with the use of scolicidal solutions in liver hydatid disease draining into the biliary system. In this study, we investigated the effectiveness of benzimidazole solutions, their in vitro scolicidal effects and the histopathological changes in the hepatobiliary system due to their intraoperative use. It was found that 5 mg% mebendazole and 1 mg% albendazole have strong scolicidal effects. In an in vivo study, under general anesthesia, 5% mebendazole in group I, 1% albendazole in group II and normal saline in group III were injected into the biliary system of rabbits. Liver biochemical tests showed no significant changes. More elaborate ductal mucosal proliferation, ductal dilatation and periductal fibrosis were found in group I compared with group II in biopsies taken on the 60th day. The biopsies of group III were normal. SN - 0014-312X UR - https://www.unboundmedicine.com/medline/citation/7589006/The_effect_of_intraoperative_mebendazole_albendazole_applications_on_the_hepatobiliary_system_ L2 - https://www.karger.com?DOI=10.1159/000129418 DB - PRIME DP - Unbound Medicine ER -