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Hormonal oral contraceptives, urinary porphyrin excretion and porphyrias.
Horm Metab Res. 1995 Aug; 27(8):379-83.HM

Abstract

The influence of hormonal oral contraceptives on the urinary porphyrin excretion of 40 healthy females has been studied. Two different hormonal oral contraceptives (combinations of gestoden or desogestrel, respectively, and ethinylestradiol) were applied for half a year. In each case twenty women received one of these two combinations. Porphyrin precursors delta-aminolevulinic acid and porphobilinogen were normal in all subjects as well as the mean of uroporphyrin and coproporphyrin. One healthy female developed a mild secondary coproporphyrinuria. In this case coproporphyrin isomer I was slightly enhanced and isomer III slightly lowered. Furthermore it could be shown that three females with repeated premenstrual clinical expression of an acute hepatic porphyria (acute intermittent porphyria and hereditary coproporphyria) could be treated successfully with a hormonal oral contraceptive or other exogenous hormones to stabilize the latent, subclinical phase of the disease.

Authors+Show Affiliations

Abteilung für Klinische Biochemie, Klinikum der Philipps-Universität, Marburg, Germany.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

7590628

Citation

Gross, U, et al. "Hormonal Oral Contraceptives, Urinary Porphyrin Excretion and Porphyrias." Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Metabolisme, vol. 27, no. 8, 1995, pp. 379-83.
Gross U, Honcamp M, Daume E, et al. Hormonal oral contraceptives, urinary porphyrin excretion and porphyrias. Horm Metab Res. 1995;27(8):379-83.
Gross, U., Honcamp, M., Daume, E., Frank, M., Düsterberg, B., & Doss, M. O. (1995). Hormonal oral contraceptives, urinary porphyrin excretion and porphyrias. Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Metabolisme, 27(8), 379-83.
Gross U, et al. Hormonal Oral Contraceptives, Urinary Porphyrin Excretion and Porphyrias. Horm Metab Res. 1995;27(8):379-83. PubMed PMID: 7590628.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hormonal oral contraceptives, urinary porphyrin excretion and porphyrias. AU - Gross,U, AU - Honcamp,M, AU - Daume,E, AU - Frank,M, AU - Düsterberg,B, AU - Doss,M O, PY - 1995/8/1/pubmed PY - 1995/8/1/medline PY - 1995/8/1/entrez KW - Biology KW - Contraception KW - Contraceptive Agents KW - Contraceptive Agents, Female KW - Contraceptive Agents, Progestin KW - Contraceptive Methods KW - Dermatitis KW - Desogestrel KW - Developed Countries KW - Diseases KW - Double-blind Studies KW - Europe KW - Family Planning KW - Germany KW - Gestodene KW - Hepatic Effects KW - Menstruation Disorders KW - Oral Contraceptives KW - Oral Contraceptives, Combined KW - Physiology KW - Porphyria KW - Premenstrual Tension KW - Research Methodology KW - Research Report KW - Studies KW - Treatment KW - Western Europe SP - 379 EP - 83 JF - Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme JO - Horm. Metab. Res. VL - 27 IS - 8 N2 - The influence of hormonal oral contraceptives on the urinary porphyrin excretion of 40 healthy females has been studied. Two different hormonal oral contraceptives (combinations of gestoden or desogestrel, respectively, and ethinylestradiol) were applied for half a year. In each case twenty women received one of these two combinations. Porphyrin precursors delta-aminolevulinic acid and porphobilinogen were normal in all subjects as well as the mean of uroporphyrin and coproporphyrin. One healthy female developed a mild secondary coproporphyrinuria. In this case coproporphyrin isomer I was slightly enhanced and isomer III slightly lowered. Furthermore it could be shown that three females with repeated premenstrual clinical expression of an acute hepatic porphyria (acute intermittent porphyria and hereditary coproporphyria) could be treated successfully with a hormonal oral contraceptive or other exogenous hormones to stabilize the latent, subclinical phase of the disease. SN - 0018-5043 UR - https://www.unboundmedicine.com/medline/citation/7590628/Hormonal_oral_contraceptives_urinary_porphyrin_excretion_and_porphyrias_ L2 - http://www.thieme-connect.com/DOI/DOI?10.1055/s-2007-979983 DB - PRIME DP - Unbound Medicine ER -