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Uroporphyrinogen decarboxylase.
J Bioenerg Biomembr. 1995 Apr; 27(2):207-14.JB

Abstract

Uroporphyrinogen decarboxylase (EC 4.1.1.37) catalyzes the decarboxylation of uroporphyrinogen III to coproporphyrinogen III. The amino acid sequences, kinetic properties, and physicochemical characteristics of enzymes from different sources (mammals, yeast, bacteria) are similar, but little is known about the structure/function relationships of uroporphyrinogen decarboxylases. Halogenated and other aromatic hydrocarbons cause hepatic uroporphyria by decreasing hepatic uroporphyrinogen decarboxylase activity. Two related human porphyrias, porphyria cutanea tarda and hepatoerythropoietic porphyria, also result from deficiency of this enzyme. The roles of inherited and acquired factors, including iron, in the pathogenesis of human and experimental uroporphyrias are reviewed.

Authors+Show Affiliations

Department of Medical Biochemistry, University of Wales College of Medicine, Cardiff, England.No affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

7592567

Citation

Elder, G H., and A G. Roberts. "Uroporphyrinogen Decarboxylase." Journal of Bioenergetics and Biomembranes, vol. 27, no. 2, 1995, pp. 207-14.
Elder GH, Roberts AG. Uroporphyrinogen decarboxylase. J Bioenerg Biomembr. 1995;27(2):207-14.
Elder, G. H., & Roberts, A. G. (1995). Uroporphyrinogen decarboxylase. Journal of Bioenergetics and Biomembranes, 27(2), 207-14.
Elder GH, Roberts AG. Uroporphyrinogen Decarboxylase. J Bioenerg Biomembr. 1995;27(2):207-14. PubMed PMID: 7592567.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Uroporphyrinogen decarboxylase. AU - Elder,G H, AU - Roberts,A G, PY - 1995/4/1/pubmed PY - 1995/4/1/medline PY - 1995/4/1/entrez SP - 207 EP - 14 JF - Journal of bioenergetics and biomembranes JO - J Bioenerg Biomembr VL - 27 IS - 2 N2 - Uroporphyrinogen decarboxylase (EC 4.1.1.37) catalyzes the decarboxylation of uroporphyrinogen III to coproporphyrinogen III. The amino acid sequences, kinetic properties, and physicochemical characteristics of enzymes from different sources (mammals, yeast, bacteria) are similar, but little is known about the structure/function relationships of uroporphyrinogen decarboxylases. Halogenated and other aromatic hydrocarbons cause hepatic uroporphyria by decreasing hepatic uroporphyrinogen decarboxylase activity. Two related human porphyrias, porphyria cutanea tarda and hepatoerythropoietic porphyria, also result from deficiency of this enzyme. The roles of inherited and acquired factors, including iron, in the pathogenesis of human and experimental uroporphyrias are reviewed. SN - 0145-479X UR - https://www.unboundmedicine.com/medline/citation/7592567/Uroporphyrinogen_decarboxylase_ DB - PRIME DP - Unbound Medicine ER -