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Analysis of T-cell and B-cell responses to recombinant M. leprae antigens in leprosy patients and in healthy contacts: significant T-cell responses to antigens in M. leprae nonresponders.
Int J Lepr Other Mycobact Dis. 1995 Sep; 63(3):369-80.IJ

Abstract

The recognition of a panel of recombinant Mycobacterium leprae antigens by T cells and B cells from 29 borderline tuberculoid/tuberculoid (BT/TT) and 18 lepromatous leprosy (LL) patients and from 21 healthy controls (HC) in leprosy-endemic regions of Ethiopia was examined. All 11 antigenic molecules tested (including M. leprae hsp 10, hsp18, hsp65 and several novel M. leprae antigens) were shown to be recognized by T cells, but clear quantitative differences existed between reactivities induced by individual antigens. Similar quantitative differences were observed when antibody responses to hsp10 and hsp65 antigens were determined. No associations were found between the antigen-specific responses and the subject status of either BT/TT and LL patients or HC. Fifteen percent of the patients who were nonresponsive to sonicates of M. leprae showed significant T-cell responses to one or more individual M. leprae antigens. This indicates that M. leprae constituents other than the proteins tested are responsible for the M. leprae-specific nonresponsiveness in these patients, which may be exploited for the design of vaccines or immunotherapeutic modalities aimed at inducing M. leprae-specific immunity in nonresponders.

Authors+Show Affiliations

Thole JE
Department of Immunohaematology and Bloodbank, University Hospital Leiden, The Netherlands.
Janson AA
No affiliation info available
Kifle A
No affiliation info available
Howe RC
No affiliation info available
McLean K
No affiliation info available
Nurilygn A
No affiliation info available
Filley E
No affiliation info available
Shannon EJ
No affiliation info available
Bulla GJ
No affiliation info available
Hermans J
No affiliation info available

MeSH

Antibodies, BacterialAntigens, BacterialB-LymphocytesBacterial ProteinsEthiopiaHeat-Shock ProteinsHumansLeprosyLeprosy, BorderlineLeprosy, LepromatousLeprosy, TuberculoidLymphocyte ActivationMycobacterium lepraeRecombinant Fusion ProteinsT-Lymphocytes

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

7594920

Citation

Thole, J E., et al. "Analysis of T-cell and B-cell Responses to Recombinant M. Leprae Antigens in Leprosy Patients and in Healthy Contacts: Significant T-cell Responses to Antigens in M. Leprae Nonresponders." International Journal of Leprosy and Other Mycobacterial Diseases : Official Organ of the International Leprosy Association, vol. 63, no. 3, 1995, pp. 369-80.
Thole JE, Janson AA, Kifle A, et al. Analysis of T-cell and B-cell responses to recombinant M. leprae antigens in leprosy patients and in healthy contacts: significant T-cell responses to antigens in M. leprae nonresponders. Int J Lepr Other Mycobact Dis. 1995;63(3):369-80.
Thole, J. E., Janson, A. A., Kifle, A., Howe, R. C., McLean, K., Nurilygn, A., Filley, E., Shannon, E. J., Bulla, G. J., & Hermans, J. (1995). Analysis of T-cell and B-cell responses to recombinant M. leprae antigens in leprosy patients and in healthy contacts: significant T-cell responses to antigens in M. leprae nonresponders. International Journal of Leprosy and Other Mycobacterial Diseases : Official Organ of the International Leprosy Association, 63(3), 369-80.
Thole JE, et al. Analysis of T-cell and B-cell Responses to Recombinant M. Leprae Antigens in Leprosy Patients and in Healthy Contacts: Significant T-cell Responses to Antigens in M. Leprae Nonresponders. Int J Lepr Other Mycobact Dis. 1995;63(3):369-80. PubMed PMID: 7594920.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Analysis of T-cell and B-cell responses to recombinant M. leprae antigens in leprosy patients and in healthy contacts: significant T-cell responses to antigens in M. leprae nonresponders. A1 - Thole,J E, AU - Janson,A A, AU - Kifle,A, AU - Howe,R C, AU - McLean,K, AU - Nurilygn,A, AU - Filley,E, AU - Shannon,E J, AU - Bulla,G J, AU - Hermans,J, PY - 1995/9/1/pubmed PY - 1995/9/1/medline PY - 1995/9/1/entrez SP - 369 EP - 80 JF - International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association JO - Int J Lepr Other Mycobact Dis VL - 63 IS - 3 N2 - The recognition of a panel of recombinant Mycobacterium leprae antigens by T cells and B cells from 29 borderline tuberculoid/tuberculoid (BT/TT) and 18 lepromatous leprosy (LL) patients and from 21 healthy controls (HC) in leprosy-endemic regions of Ethiopia was examined. All 11 antigenic molecules tested (including M. leprae hsp 10, hsp18, hsp65 and several novel M. leprae antigens) were shown to be recognized by T cells, but clear quantitative differences existed between reactivities induced by individual antigens. Similar quantitative differences were observed when antibody responses to hsp10 and hsp65 antigens were determined. No associations were found between the antigen-specific responses and the subject status of either BT/TT and LL patients or HC. Fifteen percent of the patients who were nonresponsive to sonicates of M. leprae showed significant T-cell responses to one or more individual M. leprae antigens. This indicates that M. leprae constituents other than the proteins tested are responsible for the M. leprae-specific nonresponsiveness in these patients, which may be exploited for the design of vaccines or immunotherapeutic modalities aimed at inducing M. leprae-specific immunity in nonresponders. SN - 0148-916X UR - https://www.unboundmedicine.com/medline/citation/7594920/Analysis_of_T_cell_and_B_cell_responses_to_recombinant_M__leprae_antigens_in_leprosy_patients_and_in_healthy_contacts:_significant_T_cell_responses_to_antigens_in_M__leprae_nonresponders_ L2 - https://medlineplus.gov/mycobacterialinfections.html DB - PRIME DP - Unbound Medicine ER -
Grapherence [↓4]

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