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Effect of fats high in individual saturated fatty acids on plasma lipoprotein[a] levels in young healthy men.
J Lipid Res 1995; 36(7):1447-52JL

Abstract

Plasma lipoprotein[a] (Lp[a]) is associated with atherogenesis and thrombogenesis. We examined how plasma Lp[a] in healthy young men was affected by fats high in stearic (C18), palmitic (C16), and lauric+myristic (C12+ C14) acid (experiment I, 15 subjects), and by fats high in myristic (C14) and palmitic (C16) acid (experiment II, 12 subjects). Strictly controlled isocaloric diets with 36% of energy from test fats were served in random order for 3 weeks separated by wash-out period(s). Diets high in C18 gave significantly higher levels of Lp[a] (51(12-560) mg/L) than diets high in C16 (38(12-533 mg/L) (P = 0.020) and C12 + C14 (34(12-534) mg/L) (P = 0.002). These differences were observed in several of the subjects in experiment I. In experiment II we saw no difference in plasma Lp[a] after diets high in C16 and C14. Our observations suggest that a fat high in stearic acid might affect Lp[a] in a different way than fats high in palmitic and myristic+lauric acid. Lp[a] concentrations were not associate with changes in tissue-plasminogen activator (t-PA) activity, factor VII coagualant activity, or plasma LDL cholesterol.

Authors+Show Affiliations

Research Department of Human Nutrition, Royal Veterinary and Agricultural University, Frederiksberg, Denmark.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

7595068

Citation

Tholstrup, T, et al. "Effect of Fats High in Individual Saturated Fatty Acids On Plasma Lipoprotein[a] Levels in Young Healthy Men." Journal of Lipid Research, vol. 36, no. 7, 1995, pp. 1447-52.
Tholstrup T, Marckmann P, Vessby B, et al. Effect of fats high in individual saturated fatty acids on plasma lipoprotein[a] levels in young healthy men. J Lipid Res. 1995;36(7):1447-52.
Tholstrup, T., Marckmann, P., Vessby, B., & Sandström, B. (1995). Effect of fats high in individual saturated fatty acids on plasma lipoprotein[a] levels in young healthy men. Journal of Lipid Research, 36(7), pp. 1447-52.
Tholstrup T, et al. Effect of Fats High in Individual Saturated Fatty Acids On Plasma Lipoprotein[a] Levels in Young Healthy Men. J Lipid Res. 1995;36(7):1447-52. PubMed PMID: 7595068.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of fats high in individual saturated fatty acids on plasma lipoprotein[a] levels in young healthy men. AU - Tholstrup,T, AU - Marckmann,P, AU - Vessby,B, AU - Sandström,B, PY - 1995/7/1/pubmed PY - 1995/7/1/medline PY - 1995/7/1/entrez SP - 1447 EP - 52 JF - Journal of lipid research JO - J. Lipid Res. VL - 36 IS - 7 N2 - Plasma lipoprotein[a] (Lp[a]) is associated with atherogenesis and thrombogenesis. We examined how plasma Lp[a] in healthy young men was affected by fats high in stearic (C18), palmitic (C16), and lauric+myristic (C12+ C14) acid (experiment I, 15 subjects), and by fats high in myristic (C14) and palmitic (C16) acid (experiment II, 12 subjects). Strictly controlled isocaloric diets with 36% of energy from test fats were served in random order for 3 weeks separated by wash-out period(s). Diets high in C18 gave significantly higher levels of Lp[a] (51(12-560) mg/L) than diets high in C16 (38(12-533 mg/L) (P = 0.020) and C12 + C14 (34(12-534) mg/L) (P = 0.002). These differences were observed in several of the subjects in experiment I. In experiment II we saw no difference in plasma Lp[a] after diets high in C16 and C14. Our observations suggest that a fat high in stearic acid might affect Lp[a] in a different way than fats high in palmitic and myristic+lauric acid. Lp[a] concentrations were not associate with changes in tissue-plasminogen activator (t-PA) activity, factor VII coagualant activity, or plasma LDL cholesterol. SN - 0022-2275 UR - https://www.unboundmedicine.com/medline/citation/7595068/Effect_of_fats_high_in_individual_saturated_fatty_acids_on_plasma_lipoprotein[a]_levels_in_young_healthy_men_ L2 - http://www.jlr.org/cgi/pmidlookup?view=long&pmid=7595068 DB - PRIME DP - Unbound Medicine ER -