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Immunomodulatory and antitumor activities of a polysaccharide-peptide complex from a mycelial culture of Tricholoma sp., a local edible mushroom.
Life Sci. 1995; 57(3):269-81.LS

Abstract

A polysaccharide-peptide complex (PSPC) with immunomodulatory and antitumor activities was obtained from a submerged mycelial culture of Tricholoma sp., a local edible mushroom. The polysaccharide-peptide complex exhibited a molecular weight of 17 K in gel filtration and a single band after SDS-polyacrylamide gel electrophoresis. It was characterized by non-adsorption on both DEAE-Sepharose CL-6B and CM-cellulose. It could activate the macrophages, stimulate the proliferation of T-cells, and inhibit the growth of sarcoma 180 in mice. It possessed more potent immunomodulatory and antitumor activities than Coriolus versicolor polysaccharopeptide (PSP) and deserves to be studied as a potential agent for immunomodulation and cancer therapy.

Authors+Show Affiliations

Wang HX
Department of Biology, Chinese University of Hong Kong, Shatin.
Liu WK
No affiliation info available
Ng TB
No affiliation info available
Ooi VE
No affiliation info available
Chang ST
No affiliation info available

MeSH

Adjuvants, ImmunologicAnimalsAntineoplastic AgentsBasidiomycotaCell DivisionChromatography, Ion ExchangeElectrophoresis, Polyacrylamide GelMacrophage ActivationMaleMiceMice, Inbred StrainsMitogensNitritesPeptidesPolysaccharidesT-Lymphocytes

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

7596231

Citation

Wang, H X., et al. "Immunomodulatory and Antitumor Activities of a Polysaccharide-peptide Complex From a Mycelial Culture of Tricholoma Sp., a Local Edible Mushroom." Life Sciences, vol. 57, no. 3, 1995, pp. 269-81.
Wang HX, Liu WK, Ng TB, et al. Immunomodulatory and antitumor activities of a polysaccharide-peptide complex from a mycelial culture of Tricholoma sp., a local edible mushroom. Life Sci. 1995;57(3):269-81.
Wang, H. X., Liu, W. K., Ng, T. B., Ooi, V. E., & Chang, S. T. (1995). Immunomodulatory and antitumor activities of a polysaccharide-peptide complex from a mycelial culture of Tricholoma sp., a local edible mushroom. Life Sciences, 57(3), 269-81.
Wang HX, et al. Immunomodulatory and Antitumor Activities of a Polysaccharide-peptide Complex From a Mycelial Culture of Tricholoma Sp., a Local Edible Mushroom. Life Sci. 1995;57(3):269-81. PubMed PMID: 7596231.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Immunomodulatory and antitumor activities of a polysaccharide-peptide complex from a mycelial culture of Tricholoma sp., a local edible mushroom. AU - Wang,H X, AU - Liu,W K, AU - Ng,T B, AU - Ooi,V E, AU - Chang,S T, PY - 1995/1/1/pubmed PY - 1995/1/1/medline PY - 1995/1/1/entrez SP - 269 EP - 81 JF - Life sciences JO - Life Sci VL - 57 IS - 3 N2 - A polysaccharide-peptide complex (PSPC) with immunomodulatory and antitumor activities was obtained from a submerged mycelial culture of Tricholoma sp., a local edible mushroom. The polysaccharide-peptide complex exhibited a molecular weight of 17 K in gel filtration and a single band after SDS-polyacrylamide gel electrophoresis. It was characterized by non-adsorption on both DEAE-Sepharose CL-6B and CM-cellulose. It could activate the macrophages, stimulate the proliferation of T-cells, and inhibit the growth of sarcoma 180 in mice. It possessed more potent immunomodulatory and antitumor activities than Coriolus versicolor polysaccharopeptide (PSP) and deserves to be studied as a potential agent for immunomodulation and cancer therapy. SN - 0024-3205 UR - https://www.unboundmedicine.com/medline/citation/7596231/Immunomodulatory_and_antitumor_activities_of_a_polysaccharide_peptide_complex_from_a_mycelial_culture_of_Tricholoma_sp__a_local_edible_mushroom_ DB - PRIME DP - Unbound Medicine ER -