Tags

Type your tag names separated by a space and hit enter

[How to detect neuropathy in leprosy].
Rev Neurol (Paris). 1994 Nov; 150(11):785-90.RN

Abstract

In leprosy, the early detection of peripheral nerve damage is essential for the prevention of disability. To date, there is no consensus on what is the best clinical test to reveal such abnormalities. In this prospective study we examined the effectiveness of five clinical tests to assess radial cutaneous nerve (RCN) damage (the most frequently involved). Light touch was assessed by two nylon threads (based on the Semmes-Weinstein monofilaments testing technique) bent on the skin at a pressure of 0.5 (N. 4 nylon) and 0.2 gram (N. 5 nylon). Pinprick and cooling sensations were examined by a needle and a drop of ether. The nerve thickness was assessed by palpation. Sensory findings were then compared to sensory nerve conduction values of the RCN and a sensitivity analysis was performed. The patient group consisted of 108 consecutive new leprosy sufferers (138 RCN) who attended the Institut de Léprologie Appliquée de Dakar during one year. Diagnosis and classification were based on Ridley and Jopling's criteria (clinical examination, skin smears and biopsy). Normal values were determined among 22 healthy subjects (44 RCN). The best tests in term of sensitivity were palpation (.60), N. 5 nylon (.65) and N. 5 + palpation (.79). Their positive predictive values were .84 (palpation), .94 (N. 5 nylon) and .83 (N. 5 + palpation). The best tests in term of area under the curve were palpation (.66), N. 5 nylon (.71) and N. 5 + palpation (.78). The results remain the same for the lepromatous or tuberculoid leprosy patients.(

ABSTRACT

TRUNCATED AT 250 WORDS)

Authors+Show Affiliations

Institut de Léprologie Appliquée de Dakar, Fondation de l'Ordre Souverain de Malte, Sénégal.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

fre

PubMed ID

7597372

Citation

Grimaud, J, et al. "[How to Detect Neuropathy in Leprosy]." Revue Neurologique, vol. 150, no. 11, 1994, pp. 785-90.
Grimaud J, Chapuis F, Verchot B, et al. [How to detect neuropathy in leprosy]. Rev Neurol (Paris). 1994;150(11):785-90.
Grimaud, J., Chapuis, F., Verchot, B., & Millan, J. (1994). [How to detect neuropathy in leprosy]. Revue Neurologique, 150(11), 785-90.
Grimaud J, et al. [How to Detect Neuropathy in Leprosy]. Rev Neurol (Paris). 1994;150(11):785-90. PubMed PMID: 7597372.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [How to detect neuropathy in leprosy]. AU - Grimaud,J, AU - Chapuis,F, AU - Verchot,B, AU - Millan,J, PY - 1994/11/1/pubmed PY - 1994/11/1/medline PY - 1994/11/1/entrez SP - 785 EP - 90 JF - Revue neurologique JO - Rev Neurol (Paris) VL - 150 IS - 11 N2 - In leprosy, the early detection of peripheral nerve damage is essential for the prevention of disability. To date, there is no consensus on what is the best clinical test to reveal such abnormalities. In this prospective study we examined the effectiveness of five clinical tests to assess radial cutaneous nerve (RCN) damage (the most frequently involved). Light touch was assessed by two nylon threads (based on the Semmes-Weinstein monofilaments testing technique) bent on the skin at a pressure of 0.5 (N. 4 nylon) and 0.2 gram (N. 5 nylon). Pinprick and cooling sensations were examined by a needle and a drop of ether. The nerve thickness was assessed by palpation. Sensory findings were then compared to sensory nerve conduction values of the RCN and a sensitivity analysis was performed. The patient group consisted of 108 consecutive new leprosy sufferers (138 RCN) who attended the Institut de Léprologie Appliquée de Dakar during one year. Diagnosis and classification were based on Ridley and Jopling's criteria (clinical examination, skin smears and biopsy). Normal values were determined among 22 healthy subjects (44 RCN). The best tests in term of sensitivity were palpation (.60), N. 5 nylon (.65) and N. 5 + palpation (.79). Their positive predictive values were .84 (palpation), .94 (N. 5 nylon) and .83 (N. 5 + palpation). The best tests in term of area under the curve were palpation (.66), N. 5 nylon (.71) and N. 5 + palpation (.78). The results remain the same for the lepromatous or tuberculoid leprosy patients.(ABSTRACT TRUNCATED AT 250 WORDS) SN - 0035-3787 UR - https://www.unboundmedicine.com/medline/citation/7597372/[How_to_detect_neuropathy_in_leprosy]_ L2 - https://medlineplus.gov/mycobacterialinfections.html DB - PRIME DP - Unbound Medicine ER -