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Selective increase of IgA rheumatoid factor in patients with gluten sensitivity.
Acta Derm Venereol. 1995 Mar; 75(2):130-2.AD

Abstract

An increased prevalence of raised autoantibodies, including rheumatoid factor, has been reported in patients with gluten sensitivity. However, rheumatoid factor has only been measured in small groups of patients and the findings have been conflicting. In this study IgM, IgG and IgA rheumatoid factor was measured in 89 patients with dermatitis herpetiformis and 22 patients with coeliac disease and compared with 89 normal controls. There was an increased prevalence of elevated IgA rheumatoid factor in the patients with dermatitis herpetiformis (13.5%; p = 0.036) and coeliac disease (18.2%; p = 0.078), while no such increase was found for the IgM or IgG rheumatoid factor isotypes. This selective increase of IgA rheumatoid factor suggests that rheumatoid factor production in patients with gluten sensitivity primarily results from immunological activation in the gut mucosa.

Authors+Show Affiliations

Department of Immunology, National University Hospital, Landspítalinn, Reykjavík, Iceland.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

7604641

Citation

Sökjer, M, et al. "Selective Increase of IgA Rheumatoid Factor in Patients With Gluten Sensitivity." Acta Dermato-venereologica, vol. 75, no. 2, 1995, pp. 130-2.
Sökjer M, Jónsson T, Bödvarsson S, et al. Selective increase of IgA rheumatoid factor in patients with gluten sensitivity. Acta Derm Venereol. 1995;75(2):130-2.
Sökjer, M., Jónsson, T., Bödvarsson, S., Jónsdóttir, I., & Valdimarsson, H. (1995). Selective increase of IgA rheumatoid factor in patients with gluten sensitivity. Acta Dermato-venereologica, 75(2), 130-2.
Sökjer M, et al. Selective Increase of IgA Rheumatoid Factor in Patients With Gluten Sensitivity. Acta Derm Venereol. 1995;75(2):130-2. PubMed PMID: 7604641.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Selective increase of IgA rheumatoid factor in patients with gluten sensitivity. AU - Sökjer,M, AU - Jónsson,T, AU - Bödvarsson,S, AU - Jónsdóttir,I, AU - Valdimarsson,H, PY - 1995/3/1/pubmed PY - 1995/3/1/medline PY - 1995/3/1/entrez SP - 130 EP - 2 JF - Acta dermato-venereologica JO - Acta Derm Venereol VL - 75 IS - 2 N2 - An increased prevalence of raised autoantibodies, including rheumatoid factor, has been reported in patients with gluten sensitivity. However, rheumatoid factor has only been measured in small groups of patients and the findings have been conflicting. In this study IgM, IgG and IgA rheumatoid factor was measured in 89 patients with dermatitis herpetiformis and 22 patients with coeliac disease and compared with 89 normal controls. There was an increased prevalence of elevated IgA rheumatoid factor in the patients with dermatitis herpetiformis (13.5%; p = 0.036) and coeliac disease (18.2%; p = 0.078), while no such increase was found for the IgM or IgG rheumatoid factor isotypes. This selective increase of IgA rheumatoid factor suggests that rheumatoid factor production in patients with gluten sensitivity primarily results from immunological activation in the gut mucosa. SN - 0001-5555 UR - https://www.unboundmedicine.com/medline/citation/7604641/Selective_increase_of_IgA_rheumatoid_factor_in_patients_with_gluten_sensitivity_ L2 - https://www.medicaljournals.se/acta/content/abstract/10.2340/0001555575130132 DB - PRIME DP - Unbound Medicine ER -