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Risk factors for open-angle glaucoma. The Barbados Eye Study.
Arch Ophthalmol 1995; 113(7):918-24AO

Abstract

OBJECTIVE

To evaluate risk factors for open-angle glaucoma among black participants in the Barbados Eye Study.

DESIGN

Population-based study of demographic, medical, ocular, familial, and other factors possibly related to open-angle glaucoma.

SETTING AND PARTICIPANTS

The Barbados Eye Study included 4709 Barbados residents identified by a simple random sample of Barbadian-born citizens, 40 to 84 years of age; participation was 84%. This report is based on the 4314 black participants examined at the study site; 302 (7%) met the Barbados Eye Study criteria for open-angle glaucoma.

DATA COLLECTION

A standardized protocol included applanation tonometry, Humphrey perimetry, fundus photography, blood pressure, anthropometry, and an interview. An ophthalmologic examination was performed for participants who met specific criteria.

MAIN OUTCOME MEASURES

Open-angle glaucoma was defined by the presence of both characteristic visual field defects and optic disc damage. Association of open-angle glaucoma with specific factors was evaluated in logistic regression analyses.

RESULTS

Age, male gender, high intraocular pressure, and family history of open-angle glaucoma were major risk factors; the latter association was stronger in men than women. Lean body mass and cataract history were the only other factors related to open-angle glaucoma. Although hypertension and diabetes were common in Barbados Eye Study participants, they were unrelated to the prevalence of open-angle glaucoma. However, associations were found with low diastolic blood pressure-intraocular pressure differences and low systolic and diastolic blood pressure/intraocular pressure ratios.

CONCLUSIONS

In the Barbados Eye Study black population, persons most likely to have open-angle glaucoma were older men and had a family history of open-angle glaucoma, high intraocular pressure, lean body mass, and cataract history. These results suggest the importance of possible genetic or familial factors in open-angle glaucoma. The role of vascular risk factors is consistent with our finding of low blood pressure to intraocular pressure relationships, but the results could be explained by the high intraocular pressure in open-angle glaucoma.

Authors+Show Affiliations

Department of Preventive Medicine, State University of New York at Stony Brook, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

7605285

Citation

Leske, M C., et al. "Risk Factors for Open-angle Glaucoma. the Barbados Eye Study." Archives of Ophthalmology (Chicago, Ill. : 1960), vol. 113, no. 7, 1995, pp. 918-24.
Leske MC, Connell AM, Wu SY, et al. Risk factors for open-angle glaucoma. The Barbados Eye Study. Arch Ophthalmol. 1995;113(7):918-24.
Leske, M. C., Connell, A. M., Wu, S. Y., Hyman, L. G., & Schachat, A. P. (1995). Risk factors for open-angle glaucoma. The Barbados Eye Study. Archives of Ophthalmology (Chicago, Ill. : 1960), 113(7), pp. 918-24.
Leske MC, et al. Risk Factors for Open-angle Glaucoma. the Barbados Eye Study. Arch Ophthalmol. 1995;113(7):918-24. PubMed PMID: 7605285.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Risk factors for open-angle glaucoma. The Barbados Eye Study. AU - Leske,M C, AU - Connell,A M, AU - Wu,S Y, AU - Hyman,L G, AU - Schachat,A P, PY - 1995/7/1/pubmed PY - 1995/7/1/medline PY - 1995/7/1/entrez SP - 918 EP - 24 JF - Archives of ophthalmology (Chicago, Ill. : 1960) JO - Arch. Ophthalmol. VL - 113 IS - 7 N2 - OBJECTIVE: To evaluate risk factors for open-angle glaucoma among black participants in the Barbados Eye Study. DESIGN: Population-based study of demographic, medical, ocular, familial, and other factors possibly related to open-angle glaucoma. SETTING AND PARTICIPANTS: The Barbados Eye Study included 4709 Barbados residents identified by a simple random sample of Barbadian-born citizens, 40 to 84 years of age; participation was 84%. This report is based on the 4314 black participants examined at the study site; 302 (7%) met the Barbados Eye Study criteria for open-angle glaucoma. DATA COLLECTION: A standardized protocol included applanation tonometry, Humphrey perimetry, fundus photography, blood pressure, anthropometry, and an interview. An ophthalmologic examination was performed for participants who met specific criteria. MAIN OUTCOME MEASURES: Open-angle glaucoma was defined by the presence of both characteristic visual field defects and optic disc damage. Association of open-angle glaucoma with specific factors was evaluated in logistic regression analyses. RESULTS: Age, male gender, high intraocular pressure, and family history of open-angle glaucoma were major risk factors; the latter association was stronger in men than women. Lean body mass and cataract history were the only other factors related to open-angle glaucoma. Although hypertension and diabetes were common in Barbados Eye Study participants, they were unrelated to the prevalence of open-angle glaucoma. However, associations were found with low diastolic blood pressure-intraocular pressure differences and low systolic and diastolic blood pressure/intraocular pressure ratios. CONCLUSIONS: In the Barbados Eye Study black population, persons most likely to have open-angle glaucoma were older men and had a family history of open-angle glaucoma, high intraocular pressure, lean body mass, and cataract history. These results suggest the importance of possible genetic or familial factors in open-angle glaucoma. The role of vascular risk factors is consistent with our finding of low blood pressure to intraocular pressure relationships, but the results could be explained by the high intraocular pressure in open-angle glaucoma. SN - 0003-9950 UR - https://www.unboundmedicine.com/medline/citation/7605285/Risk_factors_for_open_angle_glaucoma__The_Barbados_Eye_Study_ L2 - https://jamanetwork.com/journals/jamaophthalmology/fullarticle/vol/113/pg/918 DB - PRIME DP - Unbound Medicine ER -