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Circadian variation of insulin requirement in insulin dependent diabetes mellitus the relationship between circadian change in insulin demand and diurnal patterns of growth hormone, cortisol and glucagon during euglycemia.
Horm Metab Res. 1995 Mar; 27(3):141-7.HM

Abstract

In 13 subjects with type 1 (insulin dependent) diabetes mellitus the 24 hour insulin requirements to maintain euglycemia were assessed by means of feed back controlled insulin infusion. For the study steady state conditions, i.e. bed rest and fasting were required. Venous blood samples were collected, at 2 hour intervals, for the measurement of glucagon, growth hormone and cortisol. During the day, the insulin demand showed small changes. However, the early morning requirement for insulin was twice as much as the daytime demand (dawn phenomenon). There was a significant difference (p < 0.05) in the insulin requirement between 6.00 to 8.00 hours in the morning and 12.00 to 16.00 hours in the afternoon. The plasma glucagon levels showed no significant changes during the euglycemic period (median range from 28.7 to 30.1 ng/ml) (p < 0.05). The median of the growth hormone level decreased throughout the night from a peak of 4.41 ng/ml at midnight to a nadir of 1.05 ng/ml at 4.00 hours. There was a significant difference (p < 0.05) between the growth hormone concentration between midnight and the early morning. The cortisol concentration indicated a circadian variation. The median was significantly higher from 4.00 to 8.00 hours in comparison with the median at 20.00 to 24.00 hours (p < 0.05). The results of the study showed that the early morning rise in the insulin demand is related to the increased early morning cortisol secretion and to the nocturnal peaks of growth hormone concentration (p < 0.05).

Authors+Show Affiliations

Klinik für Endokrinologie, Otto von Guericke Universität Magdeburg, Medizinische Fakultät, Germany.No affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article

Language

eng

PubMed ID

7607604

Citation

Trümper, B G., et al. "Circadian Variation of Insulin Requirement in Insulin Dependent Diabetes Mellitus the Relationship Between Circadian Change in Insulin Demand and Diurnal Patterns of Growth Hormone, Cortisol and Glucagon During Euglycemia." Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Metabolisme, vol. 27, no. 3, 1995, pp. 141-7.
Trümper BG, Reschke K, Molling J. Circadian variation of insulin requirement in insulin dependent diabetes mellitus the relationship between circadian change in insulin demand and diurnal patterns of growth hormone, cortisol and glucagon during euglycemia. Horm Metab Res. 1995;27(3):141-7.
Trümper, B. G., Reschke, K., & Molling, J. (1995). Circadian variation of insulin requirement in insulin dependent diabetes mellitus the relationship between circadian change in insulin demand and diurnal patterns of growth hormone, cortisol and glucagon during euglycemia. Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Metabolisme, 27(3), 141-7.
Trümper BG, Reschke K, Molling J. Circadian Variation of Insulin Requirement in Insulin Dependent Diabetes Mellitus the Relationship Between Circadian Change in Insulin Demand and Diurnal Patterns of Growth Hormone, Cortisol and Glucagon During Euglycemia. Horm Metab Res. 1995;27(3):141-7. PubMed PMID: 7607604.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Circadian variation of insulin requirement in insulin dependent diabetes mellitus the relationship between circadian change in insulin demand and diurnal patterns of growth hormone, cortisol and glucagon during euglycemia. AU - Trümper,B G, AU - Reschke,K, AU - Molling,J, PY - 1995/3/1/pubmed PY - 1995/3/1/medline PY - 1995/3/1/entrez SP - 141 EP - 7 JF - Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme JO - Horm Metab Res VL - 27 IS - 3 N2 - In 13 subjects with type 1 (insulin dependent) diabetes mellitus the 24 hour insulin requirements to maintain euglycemia were assessed by means of feed back controlled insulin infusion. For the study steady state conditions, i.e. bed rest and fasting were required. Venous blood samples were collected, at 2 hour intervals, for the measurement of glucagon, growth hormone and cortisol. During the day, the insulin demand showed small changes. However, the early morning requirement for insulin was twice as much as the daytime demand (dawn phenomenon). There was a significant difference (p < 0.05) in the insulin requirement between 6.00 to 8.00 hours in the morning and 12.00 to 16.00 hours in the afternoon. The plasma glucagon levels showed no significant changes during the euglycemic period (median range from 28.7 to 30.1 ng/ml) (p < 0.05). The median of the growth hormone level decreased throughout the night from a peak of 4.41 ng/ml at midnight to a nadir of 1.05 ng/ml at 4.00 hours. There was a significant difference (p < 0.05) between the growth hormone concentration between midnight and the early morning. The cortisol concentration indicated a circadian variation. The median was significantly higher from 4.00 to 8.00 hours in comparison with the median at 20.00 to 24.00 hours (p < 0.05). The results of the study showed that the early morning rise in the insulin demand is related to the increased early morning cortisol secretion and to the nocturnal peaks of growth hormone concentration (p < 0.05). SN - 0018-5043 UR - https://www.unboundmedicine.com/medline/citation/7607604/Circadian_variation_of_insulin_requirement_in_insulin_dependent_diabetes_mellitus_the_relationship_between_circadian_change_in_insulin_demand_and_diurnal_patterns_of_growth_hormone_cortisol_and_glucagon_during_euglycemia_ L2 - http://www.thieme-connect.com/DOI/DOI?10.1055/s-2007-979926 DB - PRIME DP - Unbound Medicine ER -