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[Necrobiotic xanthogranuloma with eye involvement. Overview and case report].
Hautarzt 1995; 46(5):330-4H

Abstract

Necrobiotic xanthogranuloma is a rare disease marked by yellowish-brown plaques with destructive growth and a tendency to ulceration, which shows a characteristic histopathological pattern of palisading granuloma with foam cells, Touton's and foreign-body giant cells, bizarre multinuclear giant cells, cholesterol clefts and marked necrobiosis of the connective tissue. Necrobiotic xanthogranuloma is associated with IgG paraproteinaemia, and occasionally with an IgA paraproteinaemia. Ocular symptoms and visceral involvement are common. We report a case of a 53-year-old woman with periorbital necrobiotic xanthogranuloma, ocular involvement and IgG paraproteinaemia, who had undergone argon-laser treatment to no avail following a diagnosis of xanthelasma. Periorbital xanthelasma-like lesions with a tendency to ulceration in combination with unexplained ocular symptoms consisting of keratitis, scleritis, episcleritis or uveitis should suggest the diagnosis of necrobiotic xanthogranuloma, especially if they are associated with paraproteinaemia.

Authors+Show Affiliations

Klinik und Poliklinik für Dermatologie, Universität Regensburg.

Pub Type(s)

Case Reports
English Abstract
Journal Article
Review

Language

ger

PubMed ID

7607896

Citation

Hohenleutner, S, et al. "[Necrobiotic Xanthogranuloma With Eye Involvement. Overview and Case Report]." Der Hautarzt; Zeitschrift Fur Dermatologie, Venerologie, Und Verwandte Gebiete, vol. 46, no. 5, 1995, pp. 330-4.
Hohenleutner S, Hohenleutner U, Stolz W, et al. [Necrobiotic xanthogranuloma with eye involvement. Overview and case report]. Hautarzt. 1995;46(5):330-4.
Hohenleutner, S., Hohenleutner, U., Stolz, W., & Landthaler, M. (1995). [Necrobiotic xanthogranuloma with eye involvement. Overview and case report]. Der Hautarzt; Zeitschrift Fur Dermatologie, Venerologie, Und Verwandte Gebiete, 46(5), pp. 330-4.
Hohenleutner S, et al. [Necrobiotic Xanthogranuloma With Eye Involvement. Overview and Case Report]. Hautarzt. 1995;46(5):330-4. PubMed PMID: 7607896.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Necrobiotic xanthogranuloma with eye involvement. Overview and case report]. AU - Hohenleutner,S, AU - Hohenleutner,U, AU - Stolz,W, AU - Landthaler,M, PY - 1995/5/1/pubmed PY - 1995/5/1/medline PY - 1995/5/1/entrez SP - 330 EP - 4 JF - Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete JO - Hautarzt VL - 46 IS - 5 N2 - Necrobiotic xanthogranuloma is a rare disease marked by yellowish-brown plaques with destructive growth and a tendency to ulceration, which shows a characteristic histopathological pattern of palisading granuloma with foam cells, Touton's and foreign-body giant cells, bizarre multinuclear giant cells, cholesterol clefts and marked necrobiosis of the connective tissue. Necrobiotic xanthogranuloma is associated with IgG paraproteinaemia, and occasionally with an IgA paraproteinaemia. Ocular symptoms and visceral involvement are common. We report a case of a 53-year-old woman with periorbital necrobiotic xanthogranuloma, ocular involvement and IgG paraproteinaemia, who had undergone argon-laser treatment to no avail following a diagnosis of xanthelasma. Periorbital xanthelasma-like lesions with a tendency to ulceration in combination with unexplained ocular symptoms consisting of keratitis, scleritis, episcleritis or uveitis should suggest the diagnosis of necrobiotic xanthogranuloma, especially if they are associated with paraproteinaemia. SN - 0017-8470 UR - https://www.unboundmedicine.com/medline/citation/7607896/[Necrobiotic_xanthogranuloma_with_eye_involvement__Overview_and_case_report]_ L2 - http://www.diseaseinfosearch.org/result/7560 DB - PRIME DP - Unbound Medicine ER -