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Pernicious anemia and Helicobacter pylori infection in Japan: evaluation in a country with a high prevalence of infection.
Am J Gastroenterol. 1995 Jul; 90(7):1107-10.AJ

Abstract

OBJECTIVES

To evaluate the degree of gastritis and the prevalence of Helicobacter pylori in Japanese patients with pernicious anemia (PA).

METHODS

Histological assessment for mucosal atrophy and inflammation was performed in gastric biopsy specimens taken from 24 Japanese patients with PA and from 24 age- and sex-matched controls. The prevalence of H. pylori was evaluated by Giemsa staining and serum IgG antibodies. Serum gastrin and pepsinogens were determined by radioimmunoassay.

RESULTS

All patients with PA had severe fundic atrophic gastritis, and 17 (71%) also had antral atrophic gastritis. Thirteen (54%) of 24 age- and sex-matched controls had fundic atrophic gastritis, and 15 (62%) also had antral atrophic gastritis. Mucosal inflammation was identified in the fundus of all 24 patients and in 15 (62%) controls and in the antrum of 22 (92%) patients and 16 (67%) controls. H. pylori was not detected by Giemsa staining or serum IgG antibodies to H. pylori in any patient with PA but was present in 16 (67%) controls. Serum gastrin levels were significantly higher, and serum pepsinogen I, II, and the I/II ratio were significantly lower in patients than in controls (p < 0.001).

CONCLUSIONS

Our results confirm that H. pylori infection is infrequent in PA and is unlikely to be a factor in producing type A gastritis in PA.

Authors+Show Affiliations

Haruma K
First Department of Internal Medicine, Hiroshima University School of Medicine, Japan.
Komoto K
No affiliation info available
Kawaguchi H
No affiliation info available
Okamoto S
No affiliation info available
Yoshihara M
No affiliation info available
Sumii K
No affiliation info available
Kajiyama G
No affiliation info available

MeSH

AdultAgedAged, 80 and overAnemia, PerniciousFemaleGastric MucosaGastritis, AtrophicHelicobacter InfectionsHelicobacter pyloriHumansJapanMaleMiddle Aged

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

7611206

Citation

Haruma, K, et al. "Pernicious Anemia and Helicobacter Pylori Infection in Japan: Evaluation in a Country With a High Prevalence of Infection." The American Journal of Gastroenterology, vol. 90, no. 7, 1995, pp. 1107-10.
Haruma K, Komoto K, Kawaguchi H, et al. Pernicious anemia and Helicobacter pylori infection in Japan: evaluation in a country with a high prevalence of infection. Am J Gastroenterol. 1995;90(7):1107-10.
Haruma, K., Komoto, K., Kawaguchi, H., Okamoto, S., Yoshihara, M., Sumii, K., & Kajiyama, G. (1995). Pernicious anemia and Helicobacter pylori infection in Japan: evaluation in a country with a high prevalence of infection. The American Journal of Gastroenterology, 90(7), 1107-10.
Haruma K, et al. Pernicious Anemia and Helicobacter Pylori Infection in Japan: Evaluation in a Country With a High Prevalence of Infection. Am J Gastroenterol. 1995;90(7):1107-10. PubMed PMID: 7611206.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pernicious anemia and Helicobacter pylori infection in Japan: evaluation in a country with a high prevalence of infection. AU - Haruma,K, AU - Komoto,K, AU - Kawaguchi,H, AU - Okamoto,S, AU - Yoshihara,M, AU - Sumii,K, AU - Kajiyama,G, PY - 1995/7/1/pubmed PY - 1995/7/1/medline PY - 1995/7/1/entrez SP - 1107 EP - 10 JF - The American journal of gastroenterology JO - Am J Gastroenterol VL - 90 IS - 7 N2 - OBJECTIVES: To evaluate the degree of gastritis and the prevalence of Helicobacter pylori in Japanese patients with pernicious anemia (PA). METHODS: Histological assessment for mucosal atrophy and inflammation was performed in gastric biopsy specimens taken from 24 Japanese patients with PA and from 24 age- and sex-matched controls. The prevalence of H. pylori was evaluated by Giemsa staining and serum IgG antibodies. Serum gastrin and pepsinogens were determined by radioimmunoassay. RESULTS: All patients with PA had severe fundic atrophic gastritis, and 17 (71%) also had antral atrophic gastritis. Thirteen (54%) of 24 age- and sex-matched controls had fundic atrophic gastritis, and 15 (62%) also had antral atrophic gastritis. Mucosal inflammation was identified in the fundus of all 24 patients and in 15 (62%) controls and in the antrum of 22 (92%) patients and 16 (67%) controls. H. pylori was not detected by Giemsa staining or serum IgG antibodies to H. pylori in any patient with PA but was present in 16 (67%) controls. Serum gastrin levels were significantly higher, and serum pepsinogen I, II, and the I/II ratio were significantly lower in patients than in controls (p < 0.001). CONCLUSIONS: Our results confirm that H. pylori infection is infrequent in PA and is unlikely to be a factor in producing type A gastritis in PA. SN - 0002-9270 UR - https://www.unboundmedicine.com/medline/citation/7611206/Pernicious_anemia_and_Helicobacter_pylori_infection_in_Japan:_evaluation_in_a_country_with_a_high_prevalence_of_infection_ DB - PRIME DP - Unbound Medicine ER -