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Effect of lipid oxidation on the regulation of glucose utilization in obese patients.
Acta Diabetol. 1995 Mar; 32(1):44-8.AD

Abstract

The effect of changes in lipid oxidation on glucose utilization (storage and oxidation) was studied in seven nondiabetic obese patients. They participated in three protocols in which: (1) Intralipid (to raise plasma FFA concentrations), (2) beta-pyridylcarbinol [a precursor of nicotinic acid, to lower plasma free fatty acids (FFA) concentrations], or (3) isotonic saline were infused over 2 h. Thereafter, these infusions were discontinued, and a 2-h euglycemic, hyperinsulinemic clamp was performed to measure glucose uptake. All studies were carried out in combination with indirect calorimetry to measure oxidative and nonoxidative glucose disposal (glucose storage). The high plasma FFA concentrations (1024 +/- 57 mumol/l) and lipid oxidation rates (1.1 +/- 0.1 mg/kg.min) found at the end of the Intralipid infusion and the low plasma FFA concentrations (264 +/- 26 mumol/l) and lipid oxidation rates (0.7 +/- 0.1 mg/kg.min) found at the end of the beta-pyridylcarbinol infusions resulted in significantly different rates of total and nonoxidative glucose disposal during the insulin clamp. The values were 2.6 +/- 0.6 mg/kg.min after Intralipid and 4.1 +/- 1.0 mg/kg.min after beta-pyridylcarbinol for total glucose disposal, and 0.4 +/- 0.4 and 1.6 +/- 0.8, respectively for nonoxidative glucose disposal. In conclusion, these observations show that changes in lipid oxidation rates preceding a glucose load influence glucose disposal and glycogen storage in obese subjects.

Authors+Show Affiliations

Department of Medicine, University Hospital, Geneva, Switzerland.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

7612917

Citation

Golay, A, et al. "Effect of Lipid Oxidation On the Regulation of Glucose Utilization in Obese Patients." Acta Diabetologica, vol. 32, no. 1, 1995, pp. 44-8.
Golay A, Felber JP, Jallut D, et al. Effect of lipid oxidation on the regulation of glucose utilization in obese patients. Acta Diabetol. 1995;32(1):44-8.
Golay, A., Felber, J. P., Jallut, D., Munger, R., Ruiz, J., & Jéquier, E. (1995). Effect of lipid oxidation on the regulation of glucose utilization in obese patients. Acta Diabetologica, 32(1), 44-8.
Golay A, et al. Effect of Lipid Oxidation On the Regulation of Glucose Utilization in Obese Patients. Acta Diabetol. 1995;32(1):44-8. PubMed PMID: 7612917.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of lipid oxidation on the regulation of glucose utilization in obese patients. AU - Golay,A, AU - Felber,J P, AU - Jallut,D, AU - Munger,R, AU - Ruiz,J, AU - Jéquier,E, PY - 1995/3/1/pubmed PY - 1995/3/1/medline PY - 1995/3/1/entrez SP - 44 EP - 8 JF - Acta diabetologica JO - Acta Diabetol VL - 32 IS - 1 N2 - The effect of changes in lipid oxidation on glucose utilization (storage and oxidation) was studied in seven nondiabetic obese patients. They participated in three protocols in which: (1) Intralipid (to raise plasma FFA concentrations), (2) beta-pyridylcarbinol [a precursor of nicotinic acid, to lower plasma free fatty acids (FFA) concentrations], or (3) isotonic saline were infused over 2 h. Thereafter, these infusions were discontinued, and a 2-h euglycemic, hyperinsulinemic clamp was performed to measure glucose uptake. All studies were carried out in combination with indirect calorimetry to measure oxidative and nonoxidative glucose disposal (glucose storage). The high plasma FFA concentrations (1024 +/- 57 mumol/l) and lipid oxidation rates (1.1 +/- 0.1 mg/kg.min) found at the end of the Intralipid infusion and the low plasma FFA concentrations (264 +/- 26 mumol/l) and lipid oxidation rates (0.7 +/- 0.1 mg/kg.min) found at the end of the beta-pyridylcarbinol infusions resulted in significantly different rates of total and nonoxidative glucose disposal during the insulin clamp. The values were 2.6 +/- 0.6 mg/kg.min after Intralipid and 4.1 +/- 1.0 mg/kg.min after beta-pyridylcarbinol for total glucose disposal, and 0.4 +/- 0.4 and 1.6 +/- 0.8, respectively for nonoxidative glucose disposal. In conclusion, these observations show that changes in lipid oxidation rates preceding a glucose load influence glucose disposal and glycogen storage in obese subjects. SN - 0940-5429 UR - https://www.unboundmedicine.com/medline/citation/7612917/Effect_of_lipid_oxidation_on_the_regulation_of_glucose_utilization_in_obese_patients_ L2 - https://medlineplus.gov/obesity.html DB - PRIME DP - Unbound Medicine ER -