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[Clinical usefulness of MRI in acute phase of spinal multiple sclerosis--influence of high-dose steroid therapy in acute phase].
Rinsho Shinkeigaku. 1995 Mar; 35(3):225-30.RS

Abstract

Magnetic resonance imaging (MRI) is useful for detecting spinal cord lesions in multiple sclerosis (MS). In this study, we have examined MRI for 14 patients (26 cases) with clinically definite MS and investigated the correlations between neurological and MRI findings before and after high-dose corticosteroid therapy (pulse therapy). High signal intensity areas on T2-weighted images (T2WI) were found in 25 of 26 cases. In 22 cases spinal level of clinically suspected lesions were involved in these high intensity areas. T1-weighted images (T1WI) after intravenous gadolinium with diethylenetriamine pentaacetic acid (Gd-DTPA) were also obtained and in 12 of 17 cases before pulse therapy, the symptoms and enhancement of lesions correlated well. The symptoms regressed in all cases after pulse therapy, and high-intensity areas in T2WI became less distinct. Gd-DTPA enhanced areas disappeared in 6 cases and became smaller in 3 of 12 cases. Additional pulse therapy in 3 cases effectively diminished the enhanced areas in these cases. In one patient who had repeated pulse therapy, MRI showed no enhancement. In two other patients who continued on decreased steroid dose had relapses, pulse therapy was therefore started again, providing a good recovery both clinically and radiologically. The changes of MRI findings and clinical course suggest that the pathological changes in spinal MS may be caused not only by demyelination but also by parenchymal edema. Clinical and MRI concordance was significantly better with Gd-DTPA enhanced T1WI than the high-intensity areas in T2WI. Contrast enhancement gives more information about disease activity and the reaction to therapy.

Authors+Show Affiliations

Fujita Health University School of Medicine, Dept. of Radiology.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
English Abstract
Journal Article

Language

jpn

PubMed ID

7614741

Citation

Nomura, M, et al. "[Clinical Usefulness of MRI in Acute Phase of Spinal Multiple Sclerosis--influence of High-dose Steroid Therapy in Acute Phase]." Rinsho Shinkeigaku = Clinical Neurology, vol. 35, no. 3, 1995, pp. 225-30.
Nomura M, Suzumura A, Anno H, et al. [Clinical usefulness of MRI in acute phase of spinal multiple sclerosis--influence of high-dose steroid therapy in acute phase]. Rinsho Shinkeigaku. 1995;35(3):225-30.
Nomura, M., Suzumura, A., Anno, H., Miyata, E., Koga, S., & Yamamoto, H. (1995). [Clinical usefulness of MRI in acute phase of spinal multiple sclerosis--influence of high-dose steroid therapy in acute phase]. Rinsho Shinkeigaku = Clinical Neurology, 35(3), 225-30.
Nomura M, et al. [Clinical Usefulness of MRI in Acute Phase of Spinal Multiple Sclerosis--influence of High-dose Steroid Therapy in Acute Phase]. Rinsho Shinkeigaku. 1995;35(3):225-30. PubMed PMID: 7614741.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Clinical usefulness of MRI in acute phase of spinal multiple sclerosis--influence of high-dose steroid therapy in acute phase]. AU - Nomura,M, AU - Suzumura,A, AU - Anno,H, AU - Miyata,E, AU - Koga,S, AU - Yamamoto,H, PY - 1995/3/1/pubmed PY - 1995/3/1/medline PY - 1995/3/1/entrez SP - 225 EP - 30 JF - Rinsho shinkeigaku = Clinical neurology JO - Rinsho Shinkeigaku VL - 35 IS - 3 N2 - Magnetic resonance imaging (MRI) is useful for detecting spinal cord lesions in multiple sclerosis (MS). In this study, we have examined MRI for 14 patients (26 cases) with clinically definite MS and investigated the correlations between neurological and MRI findings before and after high-dose corticosteroid therapy (pulse therapy). High signal intensity areas on T2-weighted images (T2WI) were found in 25 of 26 cases. In 22 cases spinal level of clinically suspected lesions were involved in these high intensity areas. T1-weighted images (T1WI) after intravenous gadolinium with diethylenetriamine pentaacetic acid (Gd-DTPA) were also obtained and in 12 of 17 cases before pulse therapy, the symptoms and enhancement of lesions correlated well. The symptoms regressed in all cases after pulse therapy, and high-intensity areas in T2WI became less distinct. Gd-DTPA enhanced areas disappeared in 6 cases and became smaller in 3 of 12 cases. Additional pulse therapy in 3 cases effectively diminished the enhanced areas in these cases. In one patient who had repeated pulse therapy, MRI showed no enhancement. In two other patients who continued on decreased steroid dose had relapses, pulse therapy was therefore started again, providing a good recovery both clinically and radiologically. The changes of MRI findings and clinical course suggest that the pathological changes in spinal MS may be caused not only by demyelination but also by parenchymal edema. Clinical and MRI concordance was significantly better with Gd-DTPA enhanced T1WI than the high-intensity areas in T2WI. Contrast enhancement gives more information about disease activity and the reaction to therapy. SN - 0009-918X UR - https://www.unboundmedicine.com/medline/citation/7614741/[Clinical_usefulness_of_MRI_in_acute_phase_of_spinal_multiple_sclerosis__influence_of_high_dose_steroid_therapy_in_acute_phase]_ L2 - http://www.diseaseinfosearch.org/result/4969 DB - PRIME DP - Unbound Medicine ER -