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Clinical and endocrine effects of finasteride, a 5 alpha-reductase inhibitor, in women with idiopathic hirsutism.
Fertil Steril. 1995 Aug; 64(2):299-306.FS

Abstract

OBJECTIVE

To evaluate the effects of long-term administration of finasteride on hirsutism score, basal gonadotropin, and androgen secretion in women with idiopathic hirsutism.

DESIGN

Randomized single-blinded study.

PATIENTS

Eighteen patients with moderate-severe hirsutism were recruited for the study.

INTERVENTIONS

Nine hirsute patients received 7.5 mg/d oral finasteride for a period of 9 months whereas the other nine were treated with placebo. Hirsutism score, serum basal gonadotropin, androgens, estrogen, and sex hormone-binding globulin (SHBG) levels were evaluated in all patients before treatment and every 3 months during treatment.

RESULTS

After 6 and 9 months of treatment, the hirsutism score improved significantly in the patients receiving finasteride, whereas no significant modifications were observed in patients treated with placebo. The side effects observed were headache and depression of modest entity during the 1st month of treatments, whereas libido did not change. Serum levels of LH, FSH, androstenedione, unbound T, DHEAS, E2, 17 alpha-hydroxyprogesterone, and SHBG did not change during therapy. Hirsute patients treated with finasteride exhibited a marked decrease of dihydrotestosterone and a significant increase of T serum levels from the 3rd and 6th months of treatment, respectively.

CONCLUSION

Finasteride decreased the hirsutism score of patients affected by idiopathic hirsutism with few side effects during treatment. No modification of libido was observed.

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Authors+Show Affiliations

Ciotta L
Department of Obstetrics and Gynaecology, University of Catania, Italy.
Cianci A
No affiliation info available
Calogero AE
No affiliation info available
Palumbo MA
No affiliation info available
Marletta E
No affiliation info available
Sciuto A
No affiliation info available
Palumbo G
No affiliation info available

MeSH

5-alpha Reductase InhibitorsAdultAnalysis of VarianceDihydrotestosteroneFemaleFinasterideFollicle Stimulating HormoneHirsutismHumansLuteinizing HormoneSingle-Blind MethodTestosterone

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

7615107

Citation

Ciotta, L, et al. "Clinical and Endocrine Effects of Finasteride, a 5 Alpha-reductase Inhibitor, in Women With Idiopathic Hirsutism." Fertility and Sterility, vol. 64, no. 2, 1995, pp. 299-306.
Ciotta L, Cianci A, Calogero AE, et al. Clinical and endocrine effects of finasteride, a 5 alpha-reductase inhibitor, in women with idiopathic hirsutism. Fertil Steril. 1995;64(2):299-306.
Ciotta, L., Cianci, A., Calogero, A. E., Palumbo, M. A., Marletta, E., Sciuto, A., & Palumbo, G. (1995). Clinical and endocrine effects of finasteride, a 5 alpha-reductase inhibitor, in women with idiopathic hirsutism. Fertility and Sterility, 64(2), 299-306.
Ciotta L, et al. Clinical and Endocrine Effects of Finasteride, a 5 Alpha-reductase Inhibitor, in Women With Idiopathic Hirsutism. Fertil Steril. 1995;64(2):299-306. PubMed PMID: 7615107.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clinical and endocrine effects of finasteride, a 5 alpha-reductase inhibitor, in women with idiopathic hirsutism. AU - Ciotta,L, AU - Cianci,A, AU - Calogero,A E, AU - Palumbo,M A, AU - Marletta,E, AU - Sciuto,A, AU - Palumbo,G, PY - 1995/8/1/pubmed PY - 1995/8/1/medline PY - 1995/8/1/entrez SP - 299 EP - 306 JF - Fertility and sterility JO - Fertil Steril VL - 64 IS - 2 N2 - OBJECTIVE: To evaluate the effects of long-term administration of finasteride on hirsutism score, basal gonadotropin, and androgen secretion in women with idiopathic hirsutism. DESIGN: Randomized single-blinded study. PATIENTS: Eighteen patients with moderate-severe hirsutism were recruited for the study. INTERVENTIONS: Nine hirsute patients received 7.5 mg/d oral finasteride for a period of 9 months whereas the other nine were treated with placebo. Hirsutism score, serum basal gonadotropin, androgens, estrogen, and sex hormone-binding globulin (SHBG) levels were evaluated in all patients before treatment and every 3 months during treatment. RESULTS: After 6 and 9 months of treatment, the hirsutism score improved significantly in the patients receiving finasteride, whereas no significant modifications were observed in patients treated with placebo. The side effects observed were headache and depression of modest entity during the 1st month of treatments, whereas libido did not change. Serum levels of LH, FSH, androstenedione, unbound T, DHEAS, E2, 17 alpha-hydroxyprogesterone, and SHBG did not change during therapy. Hirsute patients treated with finasteride exhibited a marked decrease of dihydrotestosterone and a significant increase of T serum levels from the 3rd and 6th months of treatment, respectively. CONCLUSION: Finasteride decreased the hirsutism score of patients affected by idiopathic hirsutism with few side effects during treatment. No modification of libido was observed. SN - 0015-0282 UR - https://www.unboundmedicine.com/medline/citation/7615107/Clinical_and_endocrine_effects_of_finasteride_a_5_alpha_reductase_inhibitor_in_women_with_idiopathic_hirsutism_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0015-0282(16)57727-9 DB - PRIME DP - Unbound Medicine ER -