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Effects of weight gain and resumption of menses on reduced bone density in patients with anorexia nervosa.
Biol Psychiatry 1995; 37(8):521-7BP

Abstract

The bone mineral density (BMD) of the lumbar vertebrae (L2-L4) and of the whole body were measured in cross-sectional and longitudinal studies in female patients with eating disorders, using dual photon absorptiometry before and after weight gain with or without resumption of menses. In the cross-sectional study, the low-body-weight anorectic patients, with or without bulimia nervosa, were found to have lower BMD of the lumbar vertebrae associated with severe weight loss, low physical activity, and earlier onset and longer duration of amenorrhea. In the longitudinal study, 11 patients attained subnormal body weight (70%SBW < or = approximately < 85% SBW), 10 patients attained normal body weight (> or = 85%SBW, 6 patients of them resumed regular menses) after treatment. The BMD of the lumbar vertebrae was found to increase with weight gain, but not to the control level. The BMD was further increased with the resumption of menses in patients with anorexia nervosa. These results suggest that resumption of menses, in addition to weight gain, is essential to normalize reduced bone mineral density.

Authors+Show Affiliations

Department of Neuropsychiatry, Osaka City University Medical School, Japan.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

7619974

Citation

Iketani, T, et al. "Effects of Weight Gain and Resumption of Menses On Reduced Bone Density in Patients With Anorexia Nervosa." Biological Psychiatry, vol. 37, no. 8, 1995, pp. 521-7.
Iketani T, Kiriike N, Nakanishi S, et al. Effects of weight gain and resumption of menses on reduced bone density in patients with anorexia nervosa. Biol Psychiatry. 1995;37(8):521-7.
Iketani, T., Kiriike, N., Nakanishi, S., & Nakasuji, T. (1995). Effects of weight gain and resumption of menses on reduced bone density in patients with anorexia nervosa. Biological Psychiatry, 37(8), pp. 521-7.
Iketani T, et al. Effects of Weight Gain and Resumption of Menses On Reduced Bone Density in Patients With Anorexia Nervosa. Biol Psychiatry. 1995 Apr 15;37(8):521-7. PubMed PMID: 7619974.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of weight gain and resumption of menses on reduced bone density in patients with anorexia nervosa. AU - Iketani,T, AU - Kiriike,N, AU - Nakanishi,S, AU - Nakasuji,T, PY - 1995/4/15/pubmed PY - 1995/4/15/medline PY - 1995/4/15/entrez SP - 521 EP - 7 JF - Biological psychiatry JO - Biol. Psychiatry VL - 37 IS - 8 N2 - The bone mineral density (BMD) of the lumbar vertebrae (L2-L4) and of the whole body were measured in cross-sectional and longitudinal studies in female patients with eating disorders, using dual photon absorptiometry before and after weight gain with or without resumption of menses. In the cross-sectional study, the low-body-weight anorectic patients, with or without bulimia nervosa, were found to have lower BMD of the lumbar vertebrae associated with severe weight loss, low physical activity, and earlier onset and longer duration of amenorrhea. In the longitudinal study, 11 patients attained subnormal body weight (70%SBW < or = approximately < 85% SBW), 10 patients attained normal body weight (> or = 85%SBW, 6 patients of them resumed regular menses) after treatment. The BMD of the lumbar vertebrae was found to increase with weight gain, but not to the control level. The BMD was further increased with the resumption of menses in patients with anorexia nervosa. These results suggest that resumption of menses, in addition to weight gain, is essential to normalize reduced bone mineral density. SN - 0006-3223 UR - https://www.unboundmedicine.com/medline/citation/7619974/Effects_of_weight_gain_and_resumption_of_menses_on_reduced_bone_density_in_patients_with_anorexia_nervosa_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0006-3223(94)00182-3 DB - PRIME DP - Unbound Medicine ER -