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Comparison of spleen cell proliferation in response to Brucella abortus 2308 lipopolysaccharide or proteins in mice vaccinated with strain 19 or RB51.
Infect Immun 1995; 63(8):3199-205II

Abstract

Mice vaccinated with Brucella abortus 19 (S19) or RB51 (SRB51) had spleen cells which proliferated in response to proteins of 32, 27, 18, and < 18 kDa but not in response to proteins of 106, 80, and 49 kDa from B. abortus 2308 (S2308) following vaccination and challenge infection with S2308. Spleen cells from mice vaccinated with S19 but not with SRB51 had increased proliferation in response to S2308 lipopolysaccharide (LPS) following challenge infection with S2308. We previously reported that mice vaccinated with S19 or SRB51, which were analyzed in the current study, have increased resistance to infection with S2308 and that only mice vaccinated with S19 produce antibody to S2308 LPS (M. Stevens, S. Olsen, G. Pugh, Jr., and D. Brees, Infect. Immun. 63:264-270, 1995). The results from our current and previous studies support the contention that vaccination of mice with S19 or SRB51 induces protection from infection with S2308 by cell-mediated immune responses to the same immunodominant (32, 27, 18, and < 18 kDa) protein antigens of S2308. In addition, the absence of S2308 LPS-responsive spleen cells and antibody to S2308 LPS in mice vaccinated with SRB51 suggests that immune responses to LPS have no role in SRB51-induced protective immunity.

Authors+Show Affiliations

Brucellosis Research Unit, U.S. Department of Agriculture, Agriculture Research Service, Ames, Iowa 50010, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

7622248

Citation

Stevens, M G., et al. "Comparison of Spleen Cell Proliferation in Response to Brucella Abortus 2308 Lipopolysaccharide or Proteins in Mice Vaccinated With Strain 19 or RB51." Infection and Immunity, vol. 63, no. 8, 1995, pp. 3199-205.
Stevens MG, Olsen SC, Pugh GW. Comparison of spleen cell proliferation in response to Brucella abortus 2308 lipopolysaccharide or proteins in mice vaccinated with strain 19 or RB51. Infect Immun. 1995;63(8):3199-205.
Stevens, M. G., Olsen, S. C., & Pugh, G. W. (1995). Comparison of spleen cell proliferation in response to Brucella abortus 2308 lipopolysaccharide or proteins in mice vaccinated with strain 19 or RB51. Infection and Immunity, 63(8), pp. 3199-205.
Stevens MG, Olsen SC, Pugh GW. Comparison of Spleen Cell Proliferation in Response to Brucella Abortus 2308 Lipopolysaccharide or Proteins in Mice Vaccinated With Strain 19 or RB51. Infect Immun. 1995;63(8):3199-205. PubMed PMID: 7622248.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparison of spleen cell proliferation in response to Brucella abortus 2308 lipopolysaccharide or proteins in mice vaccinated with strain 19 or RB51. AU - Stevens,M G, AU - Olsen,S C, AU - Pugh,G W,Jr PY - 1995/8/1/pubmed PY - 2001/3/28/medline PY - 1995/8/1/entrez SP - 3199 EP - 205 JF - Infection and immunity JO - Infect. Immun. VL - 63 IS - 8 N2 - Mice vaccinated with Brucella abortus 19 (S19) or RB51 (SRB51) had spleen cells which proliferated in response to proteins of 32, 27, 18, and < 18 kDa but not in response to proteins of 106, 80, and 49 kDa from B. abortus 2308 (S2308) following vaccination and challenge infection with S2308. Spleen cells from mice vaccinated with S19 but not with SRB51 had increased proliferation in response to S2308 lipopolysaccharide (LPS) following challenge infection with S2308. We previously reported that mice vaccinated with S19 or SRB51, which were analyzed in the current study, have increased resistance to infection with S2308 and that only mice vaccinated with S19 produce antibody to S2308 LPS (M. Stevens, S. Olsen, G. Pugh, Jr., and D. Brees, Infect. Immun. 63:264-270, 1995). The results from our current and previous studies support the contention that vaccination of mice with S19 or SRB51 induces protection from infection with S2308 by cell-mediated immune responses to the same immunodominant (32, 27, 18, and < 18 kDa) protein antigens of S2308. In addition, the absence of S2308 LPS-responsive spleen cells and antibody to S2308 LPS in mice vaccinated with SRB51 suggests that immune responses to LPS have no role in SRB51-induced protective immunity. SN - 0019-9567 UR - https://www.unboundmedicine.com/medline/citation/7622248/Comparison_of_spleen_cell_proliferation_in_response_to_Brucella_abortus_2308_lipopolysaccharide_or_proteins_in_mice_vaccinated_with_strain_19_or_RB51_ L2 - http://iai.asm.org/cgi/pmidlookup?view=long&amp;pmid=7622248 DB - PRIME DP - Unbound Medicine ER -