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Ferric nitrilotriacetate (Fe-NTA) is a potent hepatic tumor promoter and acts through the generation of oxidative stress.
Biochem Biophys Res Commun. 1995 Jul 17; 212(2):557-63.BB

Abstract

Fe-NTA is a known renal carcinogen. However, little is known about its carcinogenic potential in liver. In this study we for the first time show that Fe-NTA is a potent hepatic tumor promoter. Fe-NTA administration induced dose dependently the hepatic ornithine decarboxylase (ODC) activity several folds as compared to its activity in the saline-treated rats. Similarly, hepatic DNA synthesis which is measured as [3H]thymidine incorporation in DNA is also increased following Fe-NTA treatment. The effects of Fe-NTA were similar to other tumor promoters not only with respect to inducing ODC activity and [3H]thymidine incorporation in DNA but also in depleting antioxidant armory of the tissue. Fe-NTA depleted levels of glutathione to about 35% of the saline-treated control and activities of antioxidant enzymes catalase, glutathione peroxidase, glutathione reductase and glucose 6-phosphate dehydrogenase decreased significantly (45-55% of saline-treated control). Concomitant with the depletion in antioxidant armory, Fe-NTA augmented hepatic microsomal lipid peroxidation more than three folds. The pretreatment of rats with antioxidants BHA or BHT diminished the observed effects of Fe-NTA. Our data indicate that Fe-NTA is a potent hepatic tumor promoter and acts through a mechanism involving oxidative stress.

Authors+Show Affiliations

Department of Medical Elementology and Toxicology, Hamdard University, New Delhi, India.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

7626070

Citation

Iqbal, M, et al. "Ferric Nitrilotriacetate (Fe-NTA) Is a Potent Hepatic Tumor Promoter and Acts Through the Generation of Oxidative Stress." Biochemical and Biophysical Research Communications, vol. 212, no. 2, 1995, pp. 557-63.
Iqbal M, Giri U, Athar M. Ferric nitrilotriacetate (Fe-NTA) is a potent hepatic tumor promoter and acts through the generation of oxidative stress. Biochem Biophys Res Commun. 1995;212(2):557-63.
Iqbal, M., Giri, U., & Athar, M. (1995). Ferric nitrilotriacetate (Fe-NTA) is a potent hepatic tumor promoter and acts through the generation of oxidative stress. Biochemical and Biophysical Research Communications, 212(2), 557-63.
Iqbal M, Giri U, Athar M. Ferric Nitrilotriacetate (Fe-NTA) Is a Potent Hepatic Tumor Promoter and Acts Through the Generation of Oxidative Stress. Biochem Biophys Res Commun. 1995 Jul 17;212(2):557-63. PubMed PMID: 7626070.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ferric nitrilotriacetate (Fe-NTA) is a potent hepatic tumor promoter and acts through the generation of oxidative stress. AU - Iqbal,M, AU - Giri,U, AU - Athar,M, PY - 1995/7/17/pubmed PY - 1995/7/17/medline PY - 1995/7/17/entrez SP - 557 EP - 63 JF - Biochemical and biophysical research communications JO - Biochem Biophys Res Commun VL - 212 IS - 2 N2 - Fe-NTA is a known renal carcinogen. However, little is known about its carcinogenic potential in liver. In this study we for the first time show that Fe-NTA is a potent hepatic tumor promoter. Fe-NTA administration induced dose dependently the hepatic ornithine decarboxylase (ODC) activity several folds as compared to its activity in the saline-treated rats. Similarly, hepatic DNA synthesis which is measured as [3H]thymidine incorporation in DNA is also increased following Fe-NTA treatment. The effects of Fe-NTA were similar to other tumor promoters not only with respect to inducing ODC activity and [3H]thymidine incorporation in DNA but also in depleting antioxidant armory of the tissue. Fe-NTA depleted levels of glutathione to about 35% of the saline-treated control and activities of antioxidant enzymes catalase, glutathione peroxidase, glutathione reductase and glucose 6-phosphate dehydrogenase decreased significantly (45-55% of saline-treated control). Concomitant with the depletion in antioxidant armory, Fe-NTA augmented hepatic microsomal lipid peroxidation more than three folds. The pretreatment of rats with antioxidants BHA or BHT diminished the observed effects of Fe-NTA. Our data indicate that Fe-NTA is a potent hepatic tumor promoter and acts through a mechanism involving oxidative stress. SN - 0006-291X UR - https://www.unboundmedicine.com/medline/citation/7626070/Ferric_nitrilotriacetate__Fe_NTA__is_a_potent_hepatic_tumor_promoter_and_acts_through_the_generation_of_oxidative_stress_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0006-291X(85)72006-2 DB - PRIME DP - Unbound Medicine ER -